The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells

Human Genetics

Volumn 120, Issue 1, 2006, Pages 101-110

  Riessland, Markus ^a   Brichta, Lars ^a   Hahnen, Eric ^a   Wirth, Brunhilde ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; M 334; M 344; RNA; SERINE PROTEINASE OMI; SURVIVAL MOTOR NEURON PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; FIBROBLAST CULTURE; GENETIC TRANSCRIPTION; HEREDITARY SPINAL MUSCULAR ATROPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSAL REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MICROSCOPY, FLUORESCENCE; MUSCULAR ATROPHY, SPINAL; NERVE TISSUE PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SMN COMPLEX PROTEINS; SURVIVAL OF MOTOR NEURON 1 PROTEIN; SURVIVAL OF MOTOR NEURON 2 PROTEIN; TRANSCRIPTION, GENETIC;

EID: 33745686137     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-006-0186-1     Document Type: Article

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