Remodeling chromatin and stress resistance in the central nervous system: Histone deacetylase inhibitors as novel and broadly effective neuroprotective agents

Current Drug Targets: CNS and Neurological Disorders

Volumn 4, Issue 1, 2005, Pages 41-50

  Langley, Brett ^a,b   Gensert, JoAnn M ^a,b   Beal, M Flint ^b   Ratan, Rajiv R ^a,b  

^a Burke Cornell Medical Research Institute   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Histone deacetylase (HDAC) inhibitors; Neuron(s); Neuroprotection

Indexed keywords

4 N ACETYLDINALINE; 4 PHENYLBUTYRIC ACID; 6 (1,3 DIOXO 1H,3H BENZO[DE]ISOQUINOLIN 2 YL) N HYDROXYHEXANAMIDE; APICIDIN; BENZAMIDE DERIVATIVE; BUTYRIC ACID; FR 901228; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NEUROPROTECTIVE AGENT; OXAMFLATIN; RETINOIC ACID; SHORT CHAIN FATTY ACID; TETRAPEPTIDE; TRAPAXIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ACYLTRANSFERASE; ENZYME INHIBITOR;

ACETYLATION; ACUTE DISEASE; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CANCER; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM DISEASE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC DISEASE; DEACETYLATION; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG POTENTIATION; DRUG SYNTHESIS; DYSPEPSIA; ENZYME ACTIVITY; ENZYME REGULATION; FATIGUE; FRAGILE X SYNDROME; GENE EXPRESSION REGULATION; HUMAN; HUNTINGTON CHOREA; HYPOCALCEMIA; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; NAUSEA; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; REVIEW; RUBINSTEIN SYNDROME; STROKE; TRANSCRIPTION INITIATION; VOMITING; ANIMAL; CELL DIVISION; CENTRAL NERVOUS SYSTEM; CHROMATIN; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; NEOPLASM; PROTEIN PROCESSING; STRESS;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; CELL DIVISION; CENTRAL NERVOUS SYSTEM; CHROMATIN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; NEOPLASMS; NERVOUS SYSTEM DISEASES; NEUROPROTECTIVE AGENTS; PROTEIN PROCESSING, POST-TRANSLATIONAL; STRESS;

EID: 20844438031     PISSN: 1568007X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568007053005091     Document Type: Review

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