Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 2, 2003, Pages 720-728

  Hu, Erding ^a   Dul, Edward ^a   Sung, Chiu Mei ^a   Chen, Zunxuan ^a   Kirkpatrick, Robert ^a   Zhang, Gui Feng ^a   Johanson, Kyung ^a   Liu, Ronggang ^a   Lago, Amparo ^a   Hofmann, Glenn ^a   Macarron, Ricardo ^a   De los Frailes, Maite ^a   Perez, Paloma ^a   Krawiec, John ^a   Winkler, James ^a,b   Jaye, Michael ^a  

^a GLAXOSMITHKLINE   (United States)

^b ARRAY BIOPHARMA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; HISTONE H4; HYBRID PROTEIN; MS 27275; N (2 AMINOPHENYL) 4 [N (PYRIDIN 3 METHYLOXYCARBONYL)AMINOMETHYL]BENZAMIDE; RECOMBINANT HUMAN HISTONE DEACETYLASE 8; RECOMBINANT PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VIRUS VECTOR;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BACULOVIRUS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIMIAN VIRUS 40; SIMIAN VIRUS 40 VECTOR;

BENZAMIDES; CLONING, MOLECULAR; COLONIC NEOPLASMS; DRUG INTERACTIONS; ENZYME INHIBITORS; GENE EXPRESSION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PROTEIN ISOFORMS; PYRIDINES; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0142179154     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055541     Document Type: Article

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