Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 42, 2004, Pages 15064-15069

  Vannini, Alessandro ^a   Volpari, Cinzia ^a   Filocamo, Gessica ^a   Casavola, Elena Caroli ^a   Brunetti, Mirko ^a   Renzoni, Debora ^a   Chakravarty, Prasun ^b   Paolini, Chantal ^a   De Francesco, Raffaele ^a   Gallinari, Paola ^a   Steinkühler, Christian ^a   Di Marco, Stefania ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APICIDIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 8 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N HYDROXY 4 [METHYL [(5 PYRIDIN 2 YL 2 THIENYL)SULFONYL]AMINO]BENZAMIDE; POTASSIUM ION; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CATALYSIS; CELL PROLIFERATION; COLON CANCER; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; STRUCTURE ANALYSIS; UTERINE CERVIX CANCER;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 6344222799     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404603101     Document Type: Article

References (21)

1. Wolffe, A. P. & Guschin, D. (2000) J. Struct. Biol. 129, 102-122.
2. Jenuwein, T. & Allis, C. D. (2001) Science 293, 1074-1080.
3. Kurdistani, S. K. & Grunstein, M. (2003) Nat. Rev. Mol. Cell Biol. 4, 276-284.
4. Hassig, C. A. & Schreiber, S. L. (1997) Curr. Opin. Chem. Biol. 1, 300-308.
5. Egger, G., Liang, G., Aparicio, A. & Jones, P. A. (2004) Nature 429, 457-463.
6. Suzuki, H., Gabrielson, E., Chen, W., Anbazhagan, R., van Engeland, M., Weijenberg, M. P., Herman, J. G. & Baylin, S. B. (2002) Nat. Genet. 31, 141-149.
7. Kramer, O. H., Gottlicher, M. & Heinzel, T. (2001) Trends Endocrinol. Metab. 12, 294-300.
8. Lee, S. C., Bottaro, A. & Insel, R. A. (2003) Mol. Immunol. 39, 923-932.
9. Johnstone, R. W. (2002) Nat. Rev. Drug Discovery 1, 287-298.
10. Gregoretti, I. V., Lee, Y. M. & Goodson, H. V. (2004) J. Mol. Biol. 338, 17-31.
11. Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R. & Pavletich, N. P. (1999) Nature 401, 188-193.
12. Hu, E., Chen, Z., Fredrickson, T., Zhu, Y., Kirkpatrick, R., Zhang, G. F., Johanson, K., Sung, C. M., Liu, R. & Winkler, J. (2000) J. Biol. Chem. 275, 15254-15264.
13. Weil, D., Garcon, L., Harper, M., Dumenil, D., Dautry, F. & Kress, M. (2002) BioTechniques 33, 1244-1248.
14. Durst, K. L., Lutterbach, B., Kummalue, T., Friedman, A. D. & Hiebert, S. W. (2003) Mol. Cell. Biol. 23, 607-619.
15. Lee, H., Rezai-Zadeh, N. & Seto, E. (2004) Mol. Cell. Biol. 24, 765-773.
16. Galasinski, S. C., Resing, K. A., Goodrich, J. A. & Ahn, N. G. (2002) J. Biol. Chem. 277, 19618-19626.
17. Nishino, N. & Powers, J. C. (1978) Biochemistry 17, 2846-2850.
18. Kam, C. M., Nishino, N. & Powers, J. C. (1979) Biochemistry 18, 3032-3038.
19. Harding, M. M. (2002) Acta Crystallogr. D 58, 872-874.
20. Mizuguchi, M., Nara, M., Kawano, K. & Nitta, K. (1997) FEBS Lett. 417, 153-156.
21. Somoza, J. R., Skene, R. J., Katz, B. A., Mol, C., Ho, J. D., Jennings, A. J., Luong, C., Arvai, A., Buggy, J. J., Chi, E., et al. (2004) Structure 7, 1325-1334.