Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 8, 2003, Pages 4389-4394

  Haggarty, Stephen J ^a,b   Koeller, Kathryn M ^b   Wong, Jason C ^b   Grozinger, Christina M ^b   Schreiber, Stuart L ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; PROTEIN; PROTEIN P58; TUBACIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL CYCLE; CELL MOTILITY; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET CELL;

3T3 CELLS; ACETYLATION; ANILIDES; ANIMALS; CELL CYCLE; CELL LINE; DIOXANES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GENE EXPRESSION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; JURKAT CELLS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TUBULIN;

ANIMALIA; MAMMALIA;

EID: 0344640906     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0430973100     Document Type: Article

References (33)

1. Grozinger, C. M. & Schreiber, S. L. (2002) Chem. Biol. 9, 3-16.
2. Khochbin, S., Verdel, A., Lemercier, C. & Seigneurin-Berny, D. (2001) Curr. Opin. Genet. Dev. 11, 162-166.
3. Yoshida, M., Kijima, M., Akita, M. & Beppu, T. (1990) J. Biol. Chem. 265, 17174-17179.
4. Kijima, M., Yoshida, M., Sugita, K., Horinouchi, S. & Beppu, T. (1993) J. Biol. Chem. 268, 22429-22435.
5. Taunton, J., Hassig, C. A. & Schreiber, S. L. (1996) Science 272, 408-411.
6. Hassig, C. A., Tong, J. K., Fleischer, T. C., Owa, T., Grable, P. G., Ayer, D. E. & Schreiber, S. L. (1998) Proc. Natl. Acad. Sci. USA 95, 3519-3524.
7. Johnstone, R. W. (2002) Nat. Rev. Drug Discovery 1, 287-299.
8. Remiszewski, S. W. (2002) Curr. Opin. Drug Discovery Dev. 5, 487-499.
9. Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y. Z., Greenwald, M., et al. (2001) Nature 413, 739-743.
10. Phiel, C. J, Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A. & Klein, P. S. (2001) J. Biol. Chem. 276, 36734-36741.
11. Polevoda, B. & Sherman, F. (2002) Genome Biol. 3, 0006.1-0006.6.
12. Koeller, K., M., Haggarty, S. J., Perkins, B. D., Leykin, I., Wong, J. C., Kao, M. C. & Schreiber, S. L. (2003) Chem. Biol., in press.
13. Stockwell, B. R., Haggarty, S. J. & Schreiber, S. L. (1999) Chem. Biol. 6, 71-83.
14. Haggarty, S. J., Koeller, K. M., Wong, J. C., Butcher, R. A. & Schreiber, S. L. (2003) Chem. Biol., in press.
15. Sternson, S. M., Wong, J. C., Grozinger, C. M. & Schreiber, S. L. (2001) Org. Lett. 3, 4239-4242.
16. Blackwell, H. E., Perez, L., Stavenger, R. A., Tallarico, J. A., Cope-Eatough, E., Foley, M. A. & Schreiber, S. L. (2001) Chem. Biol. 8, 1167-1182.
17. Clemons, P. A., Koehler, A. N., Wagner, B. K., Sprigings, T. G., Spring, D. R., King, R. W., Schreiber, S. L. & Foley, M. A. (2001) Chem. Biol. 8, 1183-1195.
18. Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X. F. & Yao, T. P. (2002) Nature 417, 455-458.
19. Li, C. & Wong, W. H. (2001) Genome Biol. 2, 0032.1-0032.11.
20. Schadt, E. E., Li, C., Ellis, B. & Wong, W. H. (2001) J. Cell Biochem. Suppl. 37, 120-125.
21. Grozinger, C. M., Hassig, C. A. & Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. USA 96, 4868-4873.
22. Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L. & Mitchison, T. J. (1999) Science 286, 971-974.
23. Taddei, A., Maison, C., Roche, D. & Almouzni, G. (2001) Nat. Cell Biol. 3, 114-120.
24. Furumai, R., Komatsu, Y., Nishino, N., Khochbin, S., Yoshida, M. & Horinouchi, S. (2001) Proc. Natl. Acad. Sci. USA 98, 87-92.
25. Schreiber, S. L. & Bernstein, B. E. (2002) Cell 111, 771-778.
26. Piperno, G., LeDizet, M. & Chang, X. J. (1987) J. Cell Biol. 104, 289-302.
27. Black, M. M., Baas, P. W. & Humphries, S. (1989) J. Neurosci. 9, 358-368.
28. Matsuyama, A., Shimazu, T., Sumida, Y., Saito, A., Yoshimatsu, Y., Seigneurin-Berny, D., Osada, H., Komatsu, Y., Nishino, N., Khochbin, S., et al. (2002) EMBO J. 21, 6820-6831.
29. Palazzo, A., Ackerman, B. & Gundersen, G. G. (2003) Nature 421, 230.
30. Thyberg, J. & Moskalewski, S. (1999) Exp. Cell Res. 1, 263-279.
31. Elyaman, W., Yardin, C. & Hugon, J. (2002) J. Neurochem. 81, 870-880.
32. Hempen, B. & Brion, J. P. (1996) J. Neuropathol. Exp. Neurol. 55, 964-972.
33. Saragoni, L, Hemandez, P. & Maccioni, R. B. (2000) Neurochem. Res. 25, 59-70.