Histone deacetylase inhibitors: The Abbott experience

Current Medicinal Chemistry

Volumn 10, Issue 22, 2003, Pages 2373-2392

  Curtin, Michael ^a   Glaser, Keith ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ketoamide; Abbott; Anti cancer; HDAC inhibitors; Hydroxamic acid; siRNA gene knockdown

Indexed keywords

7 [4 (4 CYANOPHENYL)PHENOXY]HEPTANOHYDROXAMIC ACID; ANTINEOPLASTIC AGENT; AROMATIC AMIDE; DOUBLE STRANDED RNA; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; KETONE DERIVATIVE; OXAMFLATIN; SUCCINIMIDE DERIVATIVE; TRANSFORMING GROWTH FACTOR; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CARCINOMA; CANCER CELL; CANCER CELL CULTURE; CELL ACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIENCE; FIBROSARCOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REVIEW; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141988610     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033456576     Document Type: Review

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