HDAC6 and microtubules are required for autophagic degradation of aggregated Huntingtin

Journal of Biological Chemistry

Volumn 280, Issue 48, 2005, Pages 40282-40292

  Iwata, Atsushi ^a   Riley, Brigit E ^a   Johnston, Jennifer A ^a,b   Kopito, Ron R ^a  

^a STANFORD UNIVERSITY   (United States)

^b ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST SELECTIVITY; CELLS; CYTOLOGY; DEGRADATION; OLIGOMERS;

AUTOPHAGIC DEGRADATION; CNS NEURONS; HDAC6; POLYGLUTAMINE;

PROTEINS;

GLUTAMINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HUNTINGTIN; MONOMER; OLIGOMER; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL CULTURE; CELL INCLUSION; CELL STRAIN HEK293; CELL VACUOLE; CENTRIOLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSKELETON; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; LYSOSOME; MICROTUBULE; NERVE CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION;

AUTOPHAGY; BIOLOGICAL TRANSPORT; CELL LINE; CYTOPLASM; CYTOSKELETON; DNA, COMPLEMENTARY; GREEN FLUORESCENT PROTEINS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; LYSOSOMES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MODELS, BIOLOGICAL; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PEPTIDES; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RNA INTERFERENCE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UBIQUITIN; VACUOLES;

EID: 28844475400     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508786200     Document Type: Article

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