-
1
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosome
-
Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosome. Cell 72, 971-983 (1993).
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
2
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
-
Zuccato, C. et al. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293, 493-498 (2001).
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
-
3
-
-
0028934541
-
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
-
Chong, J.A. et al. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949-957 (1995).
-
(1995)
Cell
, vol.80
, pp. 949-957
-
-
Chong, J.A.1
-
4
-
-
0028968802
-
The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
-
Schoenherr, C.J. & Anderson, D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267, 1360-1363 (1995).
-
(1995)
Science
, vol.267
, pp. 1360-1363
-
-
Schoenherr, C.J.1
Anderson, D.J.2
-
5
-
-
0029796093
-
Identification of potential target genes for the neuron-restrictive silencer factor
-
Schoenherr, C.J., Paquette, A.J & Anderson, D.J. Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl. Acad. Sci. USA 93, 9881-9886 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9881-9886
-
-
Schoenherr, C.J.1
Paquette, A.J.2
Anderson, D.J.3
-
6
-
-
0036533795
-
Lessons from animal models of Huntington's disease
-
Rubinsztein, D.C. Lessons from animal models of Huntington's disease. Trends Genet. 18, 202-209 (2002).
-
(2002)
Trends Genet.
, vol.18
, pp. 202-209
-
-
Rubinsztein, D.C.1
-
7
-
-
0035282594
-
Loss of normal huntingtin function: New developments in Huntington's disease research
-
Cattaneo, E. et al. Loss of normal huntingtin function: new developments in Huntington's disease research. Trends Neurosci. 24, 182-188 (2001).
-
(2001)
Trends Neurosci.
, vol.24
, pp. 182-188
-
-
Cattaneo, E.1
-
8
-
-
0027402152
-
Multiple promoters direct tissue-specific expression of the rat BDNF gene
-
Timmusk, T. et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475-489 (1993).
-
(1993)
Neuron
, vol.10
, pp. 475-489
-
-
Timmusk, T.1
-
9
-
-
0028891189
-
Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice
-
Timmusk, T. et al. Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice. J. Cell Biol. 128, 185-199 (1995).
-
(1995)
J. Cell Biol.
, vol.128
, pp. 185-199
-
-
Timmusk, T.1
-
10
-
-
0035125552
-
ST14A cells have properties of a medium-spiny neuron
-
Ehrlich, M.E. et al. ST14A cells have properties of a medium-spiny neuron. Exp. Neurol. 167, 215-226 (2001).
-
(2001)
Exp. Neurol.
, vol.167
, pp. 215-226
-
-
Ehrlich, M.E.1
-
11
-
-
0034657112
-
Wild-type huntingtin protects from apoptosis upstream of caspase- 3
-
Rigamonti, D. et al. Wild-type huntingtin protects from apoptosis upstream of caspase-3. J. Neurosci. 20, 3705-3713 (2000).
-
(2000)
J. Neurosci.
, vol.20
, pp. 3705-3713
-
-
Rigamonti, D.1
-
12
-
-
0034703869
-
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
-
Trettel, F. et al. Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum. Mol. Genet. 9, 2799-2809 (2000).
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2799-2809
-
-
Trettel, F.1
-
13
-
-
0029055717
-
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
-
Nasir, J. et al. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81, 811-823 (1995).
-
(1995)
Cell
, vol.81
, pp. 811-823
-
-
Nasir, J.1
-
14
-
-
0033534468
-
Brain-derived neurotrophic Factor expression in vivo is under the control of neuron-restrictive silencer element
-
Timmusk, T., Palm, K., Lendahl, U. & Metsis, M. brain-derived neurotrophic Factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biol. Chem. 274, 1078-1084 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1078-1084
-
-
Timmusk, T.1
Palm, K.2
Lendahl, U.3
Metsis, M.4
-
15
-
-
0033306577
-
Transcriptional repression by REST: Recruitment of Sin 3A and histone deacetylase to neuronal genes
-
Huang, Y., Myers, S.J. & Dingledine, R. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat. Neurosci. 2, 867-872 (1999).
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 867-872
-
-
Huang, Y.1
Myers, S.J.2
Dingledine, R.3
-
16
-
-
17944383136
-
Regulation of neuronal traits by a novel transcriptional complex
-
Ballas, N. et al. Regulation of neuronal traits by a novel transcriptional complex. Neuron 31, 353-365 (2001).
-
(2001)
Neuron
, vol.31
, pp. 353-365
-
-
Ballas, N.1
-
17
-
-
0032519868
-
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
-
Palm, K., Belluardo, N., Metsis, M. & Timmusk, T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18, 1280-1296 (1998).
-
(1998)
J. Neurosci.
, vol.18
, pp. 1280-1296
-
-
Palm, K.1
Belluardo, N.2
Metsis, M.3
Timmusk, T.4
-
18
-
-
0032846641
-
Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
-
Palm, K., Metsis, M. & Timmusk, T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res. Mol. Brain Res. 72, 30-39 (1999).
-
(1999)
Brain Res. Mol. Brain Res.
, vol.72
, pp. 30-39
-
-
Palm, K.1
Metsis, M.2
Timmusk, T.3
-
19
-
-
0034050452
-
Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor
-
Koenigsberger, C., Chicca, J.J.2nd, Amoureux, M.C., Edelman, G.M. & Jones, F.S. Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor Proc. Natl. Acad. Sci. USA 97, 2291-2296 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2291-2296
-
-
Koenigsberger, C.1
Chicca J.J. II2
Amoureux, M.C.3
Edelman, G.M.4
Jones, F.S.5
-
20
-
-
0034233725
-
Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element
-
Lee, J.H., Shimojo, M., Chai, Y.G. & Hersh, L.B. Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element. Brain Res. Mol. Brain Res. 80, 88-98 (2000).
-
(2000)
Brain Res. Mol. Brain Res.
, vol.80
, pp. 88-98
-
-
Lee, J.H.1
Shimojo, M.2
Chai, Y.G.3
Hersh, L.B.4
-
21
-
-
0035918268
-
Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization
-
Shimojo, M., Lee, J.H. & Hersh, L.B. Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization. J. Biol. Chem. 276, 13121-13126 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13121-13126
-
-
Shimojo, M.1
Lee, J.H.2
Hersh, L.B.3
-
22
-
-
0033136692
-
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
-
Hodgson, J.G. et al. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neurol 23, 181-192 (1999).
-
(1999)
Neurol
, vol.23
, pp. 181-192
-
-
Hodgson, J.G.1
-
23
-
-
0035179456
-
Mutant protein in Huntington's disease is resistant to proteolysis in affected brain
-
Dyer, R.B. & McMurray, C.T. Mutant protein in Huntington's disease is resistant to proteolysis in affected brain. Nat. Genet. 29, 270-278 (2001).
-
(2001)
Nat. Genet.
, vol.29
, pp. 270-278
-
-
Dyer, R.B.1
McMurray, C.T.2
-
24
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
Wellington, C.L. et al. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 273, 9158-9167 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
-
25
-
-
0035940412
-
Caspase 3 cleavage N-terminal fragment of wild-type or mutant huntingtin are presented in normal and Huntington's disease brain associate with membrains and undergo calpain dependent proteolysis
-
Kim, Y.J. et al. Caspase 3 cleavage N-terminal fragment of wild-type or mutant huntingtin are presented in normal and Huntington's disease brain associate with membrains and undergo calpain dependent proteolysis. Proc. Natl. Acad. Sci. USA 98, 12784-12789 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
-
26
-
-
0037096376
-
Calpain activation in Huntington's disease
-
Gafni, J & Ellerby, L.M. Calpain activation in Huntington's disease. J. Neurosci. 22, 4842-4849 (2002).
-
(2002)
J. Neurosci.
, vol.22
, pp. 4842-4849
-
-
Gafni, J.1
Ellerby, L.M.2
-
27
-
-
0141531987
-
Depletion of wild-type Huntingtin in mouse models of neurologic diseases
-
in the press
-
Zhang, Y et al. Depletion of wild-type Huntingtin in mouse models of neurologic diseases. J. Neurochem. (in the press).
-
J. Neurochem.
-
-
Zhang, Y.1
-
28
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
Steffan, J.S. et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739-743 (2001).
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
-
29
-
-
0037131263
-
Calcium-dependent cleavage of endogenous wild-type Huntingtin in primary cortical neurons
-
Goffredo, D. et al. Calcium-dependent cleavage of endogenous wild-type Huntingtin in primary cortical neurons. J. Biol. Chem. 277, 39594-39598 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39594-39598
-
-
Goffredo, D.1
-
30
-
-
0022893665
-
Tissue-specific in vitro transcription from the mouse albumin promoter
-
Gorski, K., Carneiro, M. & Schibler, U. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47, 767-776 (1986).
-
(1986)
Cell
, vol.47
, pp. 767-776
-
-
Gorski, K.1
Carneiro, M.2
Schibler, U.3
|