Sirtuins in aging and disease

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 72, Issue , 2007, Pages 483-488

  Guarente, L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE; SIRTUIN; RESVERATROL; SIRTUIN 1;

AGING; ANIMAL; BIOLOGICAL MODEL; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; GENERAL ASPECTS OF DISEASE; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; MOUSE; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE; METABOLIC PARAMETERS; MITOCHONDRIAL BIOGENESIS; NONHUMAN; OVERNUTRITION; SIGNAL TRANSDUCTION;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; DISEASE; HUMANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SIRTUINS;

EID: 48249091971     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2007.72.024     Document Type: Conference Paper

References (55)

1. Aguilaniu H., Gustafsson L., Rigoulet M., and Nystrom T. 2003. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299: 1751.
2. Alcendon R.R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., Tian B., Wagner T., Vatner S.F., and Sadoshima J. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100: 1512.
3. Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., and Sinclair D.A. 2003. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181.
4. Araki T., Sasaki Y., and Milbrandt J. 2004. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305: 1010.
5. Barja G. 2007. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: Implications for aging studies. Rejuvenation Res. 10: 215.
6. Barros M.H., Bandy B., Tahara E.B., and Kowaltowski A.J. 2004. Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J. Biol. Chem. 279: 49883.
7. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., and Sinclair D.A. 2006. Resveratrol improves health and survival of mice on a highcalorie diet. Nature 444: 337.
8. Bishop N.A. and Guarente L. 2007. Two neurons mediate dietrestriction-induced longevity in C. elegans. Nature 447: 545.
9. Blander G. and Guarente L. 2004. The Sir2 family of protein deacetylases (review). Annu. Rev. Biochem. 73: 417.
10. Bordone L., Motta M.C., Picard F., Robinson A., Jhala U.S., Apfeld J., McDonagh T., Lemieux M., McBurney M., Szilvasi A., Easlon E.J., Lin S.J., and Guarente L. 2006. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4: e31.
11. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., Hu L.S., Cheng H.L., Jedrychowski M.P., Gygi S.P., Sinclair D.A., Alt F.W., and Greenberg M.E. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011.
12. Chen J., Zhou Y., Mueller-Steiner S., Chen L.F., Kwon H., Yi S., Mucke L., and Gan L. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J. Biol. Chem. 280: 40364.
13. Chen D., Steele A.D., Lindquist S., and Guarente L. 2005. Increase in activity during calorie restriction requires Sirt1. Science 310: 1641.
14. Civitarese A.E., Carling S., Heilbronn L.K., Hulver M.H., Ukropcova B., Deutsch W.A., Smith S.R., and Ravussin E. 2007. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4: e76.
15. Cohen H.Y., Lavu S., Bitterman K.J., Hekking B., Imahiverobo T.A., Miller C., Frye R., Ploegh H., Kessler B.M, and Sinclair D.A. 2004a. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell 13: 627.
16. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., and Sinclair D.A. 2004b. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390.
17. Easlon E., Tsang F., Dilova I., Wang C., Lu S.P., Skinner C., and Lin S.J. 2007. The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. J. Biol. Chem. 282: 6161.
18. Gerhart-Hines Z., Rodgers J.T., Bare O., Lerin C., Kim S.H., Mostoslavsky R., Alt F.W., Wu Z., and Puigserver P. 2007. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26: 1913.
19. Guarente L. 2006. Sirtuins as potential targets for metabolic syndrome. Nature 444: 868.
20. Harman D. 1956. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 11: 298.
21. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., and Guarente L. 2006. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126: 941.
22. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., and Sinclair D.A. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191.
23. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795.
24. Ingram D.K., Weindruch R., Spangler E.L., Freeman J.R., and Walford R.L. 1987. Dietary restriction benefits learning and motor performance of aged mice. J. Gerontol. 42: 78.
25. Kaeberlein M., Kirkland K.T., Fields S., and Kennedy B.K. 2004. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2: E296.
26. Kaeberlein M., Hu D., Kerr E.O., Tsuchiya M., Westman E.A., Dang N., Fields S., and Kennedy B.K. 2005a. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet. 1: e69.
27. Kaeberlein M., Powers R.W.,III, Steffen K.K., Westman E.A., Hu D., Dang N., Kerr E.O., Kirkland K.T., Fields S., and Kennedy B.K. 2005b. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193.
28. Kim D., Nguyen M.D., Dobbin M.M., Fischer A., Sananbenesi F., Rodgers J.T., Delalle I., Baur J.A., Sui G., Armour S.M., Puigserver P., Sinclair D.A., and Tsai L.H. 2007. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 26: 3169.
29. Kitamura Y.I., Kitamura T., Kruse J.P., Raum J.C., Stein R., Gu W., and Accili D. 2005. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2: 153.
30. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., and Auwerx J. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109.
31. Lamming D.W., Latorre-Esteves M., Medvedik O., Wong S.N., Tsang F.A., Wang C., Lin S.J., and Sinclair D.A. 2005. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309: 1861.
32. Landry J., Sutton A., Tafrov S.T., Heller R.C., Stebbins J., Pillus L., and Sternglanz R. 2000. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. 97: 5807.
33. Lin S.J., Defossez P.A., and Guarente L. 2000. Requirement of NAD and Sir2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126.
34. Lin S.J., Ford E., Haigis M., Liszt G., and Guarente L. 2004. Calorie restriction extends yeast lifespan by lowering the level of NADH. Genes Dev. 18: 12.
35. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., and Guarente L. 2002. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344.
36. Lin J., Handschin C., and Spiegelman B.M. 2005. Metabolic control through the PGC-1 family of transcription coactivators (review). Cell Metab. 1: 361.
37. Luo J., Nikolaev A.Y., Imai S., Chen D., Shiloh A., Guarente L., and Gu W. 2001. Negative control of p53 by Sir2a promotes cell survival under stress. Cell 107: 137.
38. Mattison J.A., Roth G.S., Lane M.A., and Ingram D.K. 2007. Dietary restriction in aging nonhuman primates. Interdiscip. Top. Gerontol. 35: 137.
39. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., and Guarente L. 2004. Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551.
40. Moynihan K.A., Grimm A.A., Plueger M.M., Bernal-Mizrachi E., Ford E., Cras-Meneur C., Permutt M.A., and Imai S. 2005. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2: 105.
41. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., and Carruba M.O. 2005. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310: 314.
42. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., and Guarente L. 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771.
43. Qin W., Yang T., Ho L., Zhao Z., Wang J., Chen L., Zhao W., Thiyagarajan M., MacGrogan D., Rodgers J.T., Puigserver P., Sadoshima J., Deng H., Pedrini S., Gandy S., Sauve A.A., and Pasinetti GM. 2006. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281: 21745.
44. Rogina B. and Helfand S.L. 2004. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. 101: 15998.
45. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. 2005. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113.
46. Sinclair D.A. and Guarente L. 1997. Extrachromosomal rDNA circles: A cause of aging in yeast. Cell 91: 1033.
47. Tissenbaum H.A. and Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227.
48. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149.
49. Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. 2005. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9: 605.
50. Wallace D.C. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine (review). Annu. Rev. Genet. 39: 359.
51. Wang J., Ho L., Qin W., Rocher A.B., Seror I., Humala N., Maniar K., Dolios G., Wang R., Hof P.R., and Pasinetti G.M. 2005. Caloric restriction attenuates beta-amyloid neuropathology in a mouses model of Alzheimer's disease. FASEB J. 19: 659.
52. Weindruch R. and Walford R. L. 1988. The retardation of aging and disease by dietary restriction. C.C. Thomas, Springfield, Illinois.
53. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., and Sinclair D. 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686.
54. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., and Mayo M.W. 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23: 2369.
55. Zhu H., Guo Q., and Mattson M.P. 1999. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation. Brain Res. 842: 224.