The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

Journal of Cell Biology

Volumn 158, Issue 4, 2002, Pages 647-657

  Schwer, Björn ^a,b   North, Brian J ^a   Frye, Roy A ^c   Ott, Melanie ^b   Verdin, Eric ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

Author keywords

11p15.5; Acetylation; Apoptosis; Chromatin; HDAC

Indexed keywords

CELL PROTEIN; HISTONE DEACETYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN SIRT3; SILENT INFORMATION REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BIOLOGICAL TRANSPORT; CELLS, CULTURED; ENZYME ACTIVATION; HELA CELLS; HISTONE DEACETYLASES; HUMANS; METALLOENDOPEPTIDASES; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NAD; PEPTIDE HYDROLASES; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; SUBMITOCHONDRIAL PARTICLES; TRANS-ACTIVATORS;

MAMMALIA;

EID: 0037135972     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200205057     Document Type: Article

References (64)

1. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
2. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
3. Processing of mitochondrial precursor proteins
4. Mitochondrial transport of cations: Channels, exchangers, and permeability transition
5. Mitochondria and cell death. Mechanistic aspects and methodological issues
6. Conserved enzymatic production and biological effect of O-acetyl ADP ribose by Sir2-like NAD+-dependent deacetylases
7. High-efficiency transformation of mammalian cells by plasmid DNA
8. The mitochondrial chaperonin hsp60 is required for its own assembly
9. Caspase cleavage enhances the apoptosis-inducing effects of BAD
10. Cytosolic NAD+ content strictly depends on ATP concentration in isolated liver cells
11. Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
12. Characterization of a human RPD3 ortholog, HDAC3
13. DNA methylation, genomic imprinting and cancer
14. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
15. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
16. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
17. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticulum
18. Cleavage-site motifs in mitochondrial targeting peptides
19. Functional reconstitution in Escherichia coli of the yeast mitochondrial matrix peptidase from its two inactive subunits
20. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
21. Sir2 links chromatin silencing, metabolism, and aging
22. Mitochondrial protein import
23. Survey of amino-terminal proreolytic cleavage sites in mitochondrial precursor proteins: Leader peprides cleaved by two matrix proeases share a three-amino acid motif
24. Uniparental paternal disomy in a genetic cancer-predisposing syndrome
25. Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import
26. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
27. Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide
28. Structural identification of 2′- and 3′-O-acetyl-ADP ribose as novel metabolites derived from the Sir2 family of beta-NAD+-dependant histone/protein deacetylases
29. Opening the door to mitochondrial protein import
30. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
31. Two mitochondrial matrix proteases act sequentially in the processing of mammalian matrix enzymes
32. Role of NAD(+) in the deacety-lase activity of the SIR2-like proteins
33. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
34. Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting
35. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
36. Negative control of p53 by Sir2alpha promotes cell survival under stress
37. Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences
38. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
39. Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
40. Analysis of elements in the substrate required for processing by mitochondrial processing peptidase
41. An efficient mRNA-dependent translation system from reticulocyte lysates
42. A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
43. Versatility of the mitochondrial protein import machinery
44. A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers
45. Amphiphilicity is essential for mitochondrial presequence function
46. Assaying protein import into mitochondria
47. Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor
48. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
49. Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase
50. Acetylacion of histones and transcription-related factors
51. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
52. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
53. Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats
54. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
55. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2
56. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
57. Calcium and pyridine nucleotide interaction in mitochondrial membranes
58. Domain structure of mitochondrial and chloroplast targeting peptides
59. Molecular characterization of cytogenetic alterations associated with the Beckwith-Wiedemann syndrome (BWS) phenotype refines the localization and suggests the gene for BWS is imprinted
60. The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria
61. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
62. Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
63. Leishmania major: Cell type dependent distribution of a 43 kDa antigen related to silent information regulatory-2 protein family
64. Identification of bovine liver micochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase