Neuronal activity-dependent cell survival mediated by transcription factor MEF2

Science

Volumn 286, Issue 5440, 1999, Pages 785-790

  Mao, Zixu ^a,c   Bonni, Azad ^a   Xia, Fen ^b   Nadal Vicens, Mireya ^a   Greenberg, Michael E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL ACTIVITY; CELL SURVIVAL; CONTROLLED STUDY; ELECTRIC ACTIVITY; GENETIC TRANSCRIPTION; GRANULE CELL; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CEREBRAL CORTEX; DIMERIZATION; DNA-BINDING PROTEINS; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; MUTATION; MYOGENIC REGULATORY FACTORS; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0033595764     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5440.785     Document Type: Article

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34. Supported by a NIH Mental Retardation Research Center grant (P30-HD18655), grants from NIH (NS28829 to M.E.G.) and Daiichi Pharmaceuticals, and an NIH training grant (5T32NS07112 to Z.M.). A.B. was supported by a postdoctoral research fellowship for physicians from the Howard Hughes Medical Institute. We thank E. N. Olson and J. D. Molkentin for providing the MEF2CR24L and MEF2CVP16 plasmids, J. Han and M. Zhao for the MEF2CS387A and GAL4MEF2C plasmids, and M. Wiedmann for technical help. We thank P. Dikkes for assistance in preparing rat brain sections and L. Hu for assistance with antibody preparation. We thank A. Shaywitz and M. Lin for their helpful review of this manuscript.