Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

Human Molecular Genetics

Volumn 13, Issue 12, 2004, Pages 1257-1265

  Helmlinger, Dominique ^a   Hardy, Sara ^a   Sasorith, Souphatta ^a   Klein, Fabrice ^a   Robert, Flavie ^a   Weber, Chantal ^a   Miguet, Laurent ^b   Potier, Noëlle ^b   Van Dorsselaer, Alain ^b   Wurtz, Jean Marie ^a   Mandel, Jean Louis ^a   Tora, Làszlò ^a   Devys, Didier ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CNRS UMR7509   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ATAXIN 7; BINDING PROTEIN; CYSTEINE; CYTOSINE; GUANINE; HISTONE ACETYLTRANSFERASE; POLYGLUTAMINE; RNA POLYMERASE; TATA BINDING PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; SPINOCEREBELLAR DEGENERATION; TRINUCLEOTIDE REPEAT;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; CONSERVED SEQUENCE; HISTONE ACETYLTRANSFERASES; HUMANS; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTATION; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE HOMOLOGY, AMINO ACID; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR TFIID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC;

ADA; MAMMALIA;

EID: 3042771651     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh139     Document Type: Article

References (42)

1. David, G., Abbas, N., Stevanin, G., Durr, A., Yvert, G., Cancel, G., Weber, C., Imbert, G., Saudou, F., Antoniou, E. et al. (1997) Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nat. Genet., 17, 65-70.
2. Michalik, A., Martin, J.J. and Van Broeckhoeven, C. (2004) Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy. Eur. J. Hum. Genet., 12, 2-15.
3. Kaytor, M.D., Duvick, L.A., Skinner, P.J., Koob, M.D., Ranum, L.P. and Orr, H.T. (1999) Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7. Hum. Mol. Genet., 8, 1657-1664.
4. Mushegian, A.R., Vishnivetskiy, S.A. and Gurevich, V.V. (2000) Conserved phosphoprotein interaction motif is functionally interchangeable between ataxin-7 and arrestins. Biochemistry, 39, 6809-6813.
5. Scheel, H., Tomiuk, S. and Hofmann, K. (2003) Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics. Hum. Mol. Genet., 12, 2845-2852.
6. Gavin, A.C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J.M., Michon, A.M., Cruciat, C.M. et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415, 141-147.
7. Sanders, S.L., Jennings, J., Canutescu, A., Link, A.J. and Weil, P.A. (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol. Cell. Biol., 22, 4723-4738.
8. Grant, P.A., Duggan, L., Cote, J., Roberts, S.M., Brownell, J.E., Candau, R., Ohba, R., Owen-Hughes, T., Allis, C.D., Winston, F. et al. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev., 11, 1640-1650.
9. Grant, P.A., Schieltz, D., Pray-Grant, M.G., Steger, D.J., Reese, J.C., Yates, J.R., III and Workman, J.L. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell, 94, 45-53.
10. Yang, X.J., Ogryzko, V.V., Nishikawa, J., Howard, B.H. and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 382, 319-324.
11. Xu, W., Edmondson, D.G. and Roth, S.Y. (1998) Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol. Cell. Biol., 18, 5659-5669.
12. Brand, M., Yamamoto, K., Staub, A. and Tora, L. (1999) Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J. Biol. Chem., 274, 18285-18289.
13. Martinez, E., Kundu, T.K., Fu, J. and Roeder, R.G. (1998) A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID. J. Biol. Chem., 273, 23781-23785.
14. Ogryzko, V.V., Kotani, T., Zhang, X., Schiltz, R.L., Howard, T., Yang, X.J., Howard, B.H., Qin, J. and Nakatani, Y. (1998) Histone-like TAFs within the PCAF histone acetylase complex. Cell, 94, 35-44.
15. Grant, P.A. and Berger, S.L. (1999) Histone acetyltransferase complexes. Semin. Cell. Dev. Biol., 10, 169-177.
16. Carrozza, M.J., Utley, R.T., Workman, J.L. and Cote, J. (2003) The diverse functions of histone acetyltransferase complexes. Trends Genet., 19, 321-329.
17. Martinez, E., Palhan, V.B., Tjernberg, A., Lymar, E.S., Gamper, A.M., Kundu, T.K., Chait, B.T. and Roeder, R.G. (2001) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol., 21, 6782-6795.
18. Hardy, S., Brand, M., Mittler, G., Yanagisawa, J., Kato, S., Meisterernst, M. and Tora, L. (2002) TATA-binding protein-free TAF-containing complex (TFTC) and p300 are both required for efficient transcriptional activation. J. Biol. Chem., 277, 32875-32882.
19. Wieczorek, E., Brand, M., Jacq, X. and Tora, L. (1998) Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II. Nature, 393, 187-191.
20. Brand, M., Moggs, J.G., Oulad-Abdelghani, M., Lejeune, F., Dilworth, F.J., Stevenin, J., Almouzni, G. and Tora, L. (2001) UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. EMBO J., 20, 3187-3196.
21. Chen, S., Peng, G.H., Wang, X., Smith, A.C., Grote, S.K., Sopher, B.L. and La Spada, A.R. (2004) Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization. Hum. Mol. Genet., 13, 53-67.
22. Worthington, M.T., Amann, B.T., Nathans, D. and Berg, J.M. (1996) Metal binding properties and secondary structure of the zinc-binding domain of Nup475. Proc. Natl Acad. Sci. USA, 93, 13754-13759.
23. Amann, B.T., Worthington, M.T. and Berg, J.M. (2003) A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure. Biochemistry, 42, 217-221.
24. Laity, J.H., Lee, B.M. and Wright, P.E. (2001) Zinc finger proteins: new insights into structural and functional diversity. Curr. Opin. Struct. Biol., 11, 39-46.
25. Kirschner, D.B., vom Baur, E., Thibault, C., Sanders, S.L., Gangloff, Y.G., Davidson, I., Weil, P.A. and Tora, L. (2002) Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns. Mol. Cell. Biol., 22, 3178-3193.
26. Tora, L. (2002) A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev., 16, 673-675.
27. Cha, J.H. (2000) Transcriptional dysregulation in Huntington's disease. Trends Neurosci., 23, 387-392.
28. Sugars, K.L. and Rubinsztein, D.C. (2003) Transcriptional abnormalities in Huntington disease. Trends Genet., 19, 233-238.
29. Steffan, J.S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B.L., Kazantsev, A., Schmidt, E., Zhu, Y.Z., Greenwald, M. et al. (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature, 413, 739-743.
30. Hockly, E., Richon, V.M., Woodman, B., Smith, D.L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi-Noori, S., Mahal, A., Lowden, P.A. et al. (2003) Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc. Natl Acad. Sci. USA, 100, 2041-2046.
31. Ferrante, R.J., Kubilus, J.K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N.W., Ratan, R.R., Luthi-Carter, R. et al. (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J. Neurosci., 23, 9418-9427.
32. La Spada, A.R., Fu, Y.H., Sopher, B.L., Libby, R.T., Wang, X., Li, L.Y., Einum, D.D., Huang, J., Possin, D.E., Smith, A.C. et al. (2001) Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron, 31, 913-927.
33. Yoo, S.Y., Pennesi, M.E., Weeber, E.J., Xu, B., Atkinson, R., Chen, S., Armstrong, D.L., Wu, S.M., Sweatt, J.D. and Zoghbi, H.Y. (2003) SCA7 Knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron, 37, 383-401.
34. Helmlinger, D., Abou-Sleymane, G., Yvert, G., Rousseau, S., Weber, C., Trottier, Y., Mandel, J.L. and Devys, D. (2004) Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model. J. Neurosci., 24, 1881-1887.
35. Yvert, G., Lindenberg, K.S., Devys, D., Helmlinger, D., Landwehrmeyer, G.B. and Mandel, J.L. (2001) SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types. Hum. Mol. Genet., 10, 1679-1692.
36. Zhang, S., Xu, L., Lee, J. and Xu, T. (2002) Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell, 108, 45-56.
37. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol., 215, 403-410.
38. Thompson, J.D., Gibson, T.J., Plewniak, F., Jeanmougin, F. and Higgins, D.G. (1997) The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucl. Acids Res., 25, 4876-4882.
39. Barton, G.J. (1993) ALSCRIPT: a tool to format multiple sequence alignments. Protein Eng., 6, 37-40.
40. Rost, B., Sander, C. and Schneider, R. (1994) PHD - an automatic mail server for protein secondary structure prediction. Comput. Appl. Biosci., 10, 53-60.
41. Yvert, G., Lindenberg, K.S., Picaud, S., Landwehrmeyer, G.B., Sahel, J.A. and Mandel, J.L. (2000) Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Hum. Mol. Genet., 9, 2491-2506.
42. Nielsen, A.L., Ortiz, J.A., You, J., Oulad-Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P. and Losson, R. (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J., 18, 6385-6395.