-
1
-
-
0035863097
-
RNA interference is mediated by 21 and 22 nt RNAs
-
Elbashir, S. M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21 and 22 nt RNAs. Genes Dev. 15, 188-200 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
2
-
-
0033615491
-
A species of small antisense RNA in posttranscriptional gene silencing in plants
-
Hamilton, A. J. & Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 206, 950-952 (1999).
-
(1999)
Science
, vol.206
, pp. 950-952
-
-
Hamilton, A.J.1
Baulcombe, D.C.2
-
3
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
4
-
-
0032417618
-
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
-
Montgomery, M. K., Xu, S. & Fire, A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 95, 15502-15507 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15502-15507
-
-
Montgomery, M.K.1
Xu, S.2
Fire, A.3
-
5
-
-
0032506226
-
Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
-
Waterhouse, P. M., Graham, M. W. & Wang, M. B. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA. Proc. Natl Acad. Sci. USA 95, 13959-13964 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13959-13964
-
-
Waterhouse, P.M.1
Graham, M.W.2
Wang, M.B.3
-
6
-
-
0032443021
-
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
-
Kennerdell, J. R. & Carthew, R. W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95, 1017-1026 (1998).
-
(1998)
Cell
, vol.95
, pp. 1017-1026
-
-
Kennerdell, J.R.1
Carthew, R.W.2
-
7
-
-
0032410928
-
Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
-
Ngo, H., Tschudi, C., Gull, K. & Ullu, E. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl Acad. Sci. USA 95, 14687-14692 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14687-14692
-
-
Ngo, H.1
Tschudi, C.2
Gull, K.3
Ullu, E.4
-
8
-
-
0032716844
-
Homology-dependent gene silencing in plants and fungi: A number of variations on the same theme
-
Cogoni, C. & Macino, G. Homology-dependent gene silencing in plants and fungi: a number of variations on the same theme. Curr. Opin. Microbiol. 2, 657-662 (1999).
-
(1999)
Curr. Opin. Microbiol.
, vol.2
, pp. 657-662
-
-
Cogoni, C.1
Macino, G.2
-
9
-
-
0031657551
-
How cells respond to interferons
-
Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264 (1998).
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.3
Silverman, R.H.4
Schreiber, R.D.5
-
10
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond, S. M., Bernstein, E., Beach, D. & Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000).
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
11
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
12
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
-
Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W. & Tuschl, T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20, 6877-6888 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
13
-
-
0035942736
-
Duplexes of 21 -nucleotide RNAs mediate RNA interference in mammalian cell culture
-
Elbashir, S. M. et al. Duplexes of 21 -nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature 411, 494-498 (2001).
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
14
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen, N. J., Parrish, S., Imani, F., Fire, A. & Morgan, R. A. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl Acad. Sci. USA 98, 9742-9747 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
15
-
-
19044381013
-
Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses
-
Bitko, V. & Barik, S. Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. BMC Microbiol. 1, 34 (2001).
-
(2001)
BMC Microbiol.
, vol.1
, pp. 34
-
-
Bitko, V.1
Barik, S.2
-
16
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
Scherer, L. J. & Rossi, J. J. Approaches for the sequence-specific knockdown of mRNA. Nature Biotechnol. 21, 1457-1465 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1457-1465
-
-
Scherer, L.J.1
Rossi, J.J.2
-
17
-
-
0037046160
-
Novel antisense and peptide nucleic acid strategies for controlling gene expression
-
Braasch, D. A. & Corey, D. R. Novel antisense and peptide nucleic acid strategies for controlling gene expression. Biochemistry 41, 4503-4510 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 4503-4510
-
-
Braasch, D.A.1
Corey, D.R.2
-
18
-
-
0037086052
-
Morpholino oligos: Making sense of antisense?
-
Heasman, J. Morpholino oligos: making sense of antisense? Dev. Biol. 243, 209-214 (2002).
-
(2002)
Dev. Biol.
, vol.243
, pp. 209-214
-
-
Heasman, J.1
-
19
-
-
0344442416
-
RNA cleaving '10-23' DNAzymes with enhanced stability and activity
-
Schubert, S. et al. RNA cleaving '10-23' DNAzymes with enhanced stability and activity. Nucleic Acids Res. 31, 5982-5992 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 5982-5992
-
-
Schubert, S.1
-
20
-
-
0038489114
-
Inhibition of HIV-1 gene expression by novel DNA enzymes targeted to cleave HIV-1 TAR RNA: Potential effectiveness against all HIV-1 isolates
-
Chakraborti, S. & Banerjea, A. C. Inhibition of HIV-1 gene expression by novel DNA enzymes targeted to cleave HIV-1 TAR RNA: potential effectiveness against all HIV-1 isolates. Mol. Ther. 7, 817-826 (2003).
-
(2003)
Mol. Ther.
, vol.7
, pp. 817-826
-
-
Chakraborti, S.1
Banerjea, A.C.2
-
21
-
-
0030898510
-
A general purpose RNA-cleaving DNA enzyme
-
Santoro, S. W. & Joyce, G. F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl Acad. Sci. USA 94, 4262-4266 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 4262-4266
-
-
Santoro, S.W.1
Joyce, G.F.2
-
22
-
-
0038492463
-
Inhibiting expression of specific genes in mammalian cells with 5′ end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA
-
Fortes, P. et al. Inhibiting expression of specific genes in mammalian cells with 5′ end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA. Proc. Natl Acad. Sci. USA 100, 8264-8269 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8264-8269
-
-
Fortes, P.1
-
23
-
-
0037733977
-
Antisense technologies. Improvement through novel chemical modifications
-
Kurreck, J. Antisense technologies. Improvement through novel chemical modifications. Eur. J. Biochem. 270, 1628-1644 (2003).
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 1628-1644
-
-
Kurreck, J.1
-
24
-
-
0031010177
-
2′-O-(2-methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
-
Baker, B. F. et al. 2′-O-(2-methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J. Biol. Chem. 272, 11994-2000 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11994-12000
-
-
Baker, B.F.1
-
25
-
-
0042536463
-
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse
-
Lu, Q. L. et al. Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. Nature Med. 9, 1009-1014 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1009-1014
-
-
Lu, Q.L.1
-
26
-
-
0344874246
-
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
-
Uil, T. G., Haisma, H. J. & Rots, M. G. Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res. 31, 6064-6078 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6064-6078
-
-
Uil, T.G.1
Haisma, H.J.2
Rots, M.G.3
-
27
-
-
0037062949
-
The chemical repertoire of natural ribozymes
-
Doudna, J. A. & Cech, T. R. The chemical repertoire of natural ribozymes. Nature 418, 222-228 (2002).
-
(2002)
Nature
, vol.418
, pp. 222-228
-
-
Doudna, J.A.1
Cech, T.R.2
-
28
-
-
0036330108
-
Cleavage of an inaccessible site by the maxizyme with two independent binding arms: An alternative approach to the recruitment of RNA helicases
-
Kuwabara, T., Warashina, M. & Taira, K. Cleavage of an inaccessible site by the maxizyme with two independent binding arms: an alternative approach to the recruitment of RNA helicases. J. Biochem. (Tokyo) 132, 149-155 (2002).
-
(2002)
J. Biochem. (Tokyo)
, vol.132
, pp. 149-155
-
-
Kuwabara, T.1
Warashina, M.2
Taira, K.3
-
29
-
-
0034814428
-
Intracellular applications of ribozymes
-
Michienzi, A. & Rossi, J. J. Intracellular applications of ribozymes. Methods Enzymol. 341, 581-596 (2001).
-
(2001)
Methods Enzymol.
, vol.341
, pp. 581-596
-
-
Michienzi, A.1
Rossi, J.J.2
-
30
-
-
8044253998
-
Expression of small, therapeutic RNAs in human cell nuclei
-
Good, P. D. et al. Expression of small, therapeutic RNAs in human cell nuclei. Gene Ther. 4, 45-54 (1997).
-
(1997)
Gene Ther.
, vol.4
, pp. 45-54
-
-
Good, P.D.1
-
31
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
32
-
-
0037031576
-
Single-stranded antisense siRNAs guide target RNA cleavage in RNA
-
Martinez, J., Patkaniowska, A., Urlaub, H., Lührmann, R. & Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNA. Cell 110, 563-574 (2002).
-
(2002)
Cell
, vol.110
, pp. 563-574
-
-
Martinez, J.1
Patkaniowska, A.2
Urlaub, H.3
Lührmann, R.4
Tuschl, T.5
-
33
-
-
0036074161
-
RNA interference in human cells is restricted to the cytoplasm
-
Zeng, Y. & Cullen, B. R. RNA interference in human cells is restricted to the cytoplasm. RNA 8, 855-860 (2002).
-
(2002)
RNA
, vol.8
, pp. 855-860
-
-
Zeng, Y.1
Cullen, B.R.2
-
34
-
-
0032080877
-
A model for RNA-mediated gene silencing in higher plants
-
Wassenegger, M. & Pelissier, T. A model for RNA-mediated gene silencing in higher plants. Plant Mol. Biol. 37, 349-362 (1998).
-
(1998)
Plant Mol. Biol.
, vol.37
, pp. 349-362
-
-
Wassenegger, M.1
Pelissier, T.2
-
35
-
-
0034596989
-
Transcriptional silencing and promoter methylation triggered by double-stranded RNA
-
Mette, M. F., Aufsatz, W., van der Winden, J., Matzke, M. A. & Matzke, A. J. M. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19, 6194-6201 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 6194-6201
-
-
Mette, M.F.1
Aufsatz, W.2
van der Winden, J.3
Matzke, M.A.4
Matzke, A.J.M.5
-
36
-
-
0032476597
-
De novo methylation and co-suppression induced by a cytoplasmically replicating plant RNA virus
-
Jones, A. L., Thomas, C. L. & Maule, A. J. De novo methylation and co-suppression induced by a cytoplasmically replicating plant RNA virus. EMBO J. 17, 6385-6393 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 6385-6393
-
-
Jones, A.L.1
Thomas, C.L.2
Maule, A.J.3
-
37
-
-
0035039978
-
Replicating satellite RNA induces sequence-specffic DNA methylation and truncated transcripts in plants
-
Wang, M.-B., Wesley, S. V., Finnegan, E. J., Smith, N. A. & Waterhouse, P. M. Replicating satellite RNA induces sequence-specffic DNA methylation and truncated transcripts in plants. RNA 7, 16-28 (2001).
-
(2001)
RNA
, vol.7
, pp. 16-28
-
-
Wang, M.-B.1
Wesley, S.V.2
Finnegan, E.J.3
Smith, N.A.4
Waterhouse, P.M.5
-
38
-
-
0035984059
-
Endogenous and silencing-associated small RNAs in plants
-
Llave, C., Kasschau, K. D., Rector, M. A. & Carrington, J. C. Endogenous and silencing-associated small RNAs in plants. Plant Cell 14, 1605-1619 (2002).
-
(2002)
Plant Cell
, vol.14
, pp. 1605-1619
-
-
Llave, C.1
Kasschau, K.D.2
Rector, M.A.3
Carrington, J.C.4
-
39
-
-
0037072661
-
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
-
Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833-1837 (2002).
-
(2002)
Science
, vol.297
, pp. 1833-1837
-
-
Volpe, T.A.1
-
40
-
-
0037072660
-
Small RNAs correspond to centromere heterochromatic repeats
-
Reinhart B. J. & Bartel, D. P. Small RNAs correspond to centromere heterochromatic repeats. Science 297, 1831 (2002).
-
(2002)
Science
, vol.297
, pp. 1831
-
-
Reinhart, B.J.1
Bartel, D.P.2
-
41
-
-
0037183856
-
Establishment and maintenance of a heterochromatin domain
-
Hall, I. M. et al. Establishment and maintenance of a heterochromatin domain. Science 297, 2232-2237 (2002).
-
(2002)
Science
, vol.297
, pp. 2232-2237
-
-
Hall, I.M.1
-
42
-
-
0942279635
-
RNAi-mediated targeting of heterochromatin by the RITS complex
-
Verdel, A. et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303, 672-676 (2004).
-
(2004)
Science
, vol.303
, pp. 672-676
-
-
Verdel, A.1
-
43
-
-
0036184188
-
RNAi related mechanism affect both transcriptional and posttranscriptional transgene silencing in Drosophila
-
Pal-Bhadra, M., Bhadra, U. & Birchler, J. A. RNAi related mechanism affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell 9, 315-327 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 315-327
-
-
Pal-Bhadra, M.1
Bhadra, U.2
Birchler, J.A.3
-
44
-
-
0942279615
-
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery
-
Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303, 669-672 (2004).
-
(2004)
Science
, vol.303
, pp. 669-672
-
-
Pal-Bhadra, M.1
-
45
-
-
0038299558
-
Role of microRNAs in plant and animal development
-
Carrington, J. C. & Ambros, V. Role of microRNAs in plant and animal development. Science 301, 336-338 (2003).
-
(2003)
Science
, vol.301
, pp. 336-338
-
-
Carrington, J.C.1
Ambros, V.2
-
46
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
47
-
-
0037009364
-
MicroRNA maturation: Stepwise processing and subcellular localization
-
Lee, Y., Jeon, K., Lee, J. T., Kim, S. & Kim, V. N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663-4670 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4663-4670
-
-
Lee, Y.1
Jeon, K.2
Lee, J.T.3
Kim, S.4
Kim, V.N.5
-
48
-
-
0033572284
-
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans, by blocking LIN-14 protein synthesis after the initiation of translation
-
Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans, by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671-680 (1999).
-
(1999)
Dev. Biol.
, vol.216
, pp. 671-680
-
-
Olsen, P.H.1
Ambros, V.2
-
49
-
-
0037085968
-
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
-
Seggerson, K., Tang, L. & Moss, E. G. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243, 215-225 (2002).
-
(2002)
Dev. Biol.
, vol.243
, pp. 215-225
-
-
Seggerson, K.1
Tang, L.2
Moss, E.G.3
-
50
-
-
0027730383
-
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elagans
-
Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elagans. Cell 75, 855-862 (1993).
-
(1993)
Cell
, vol.75
, pp. 855-862
-
-
Wightman, B.1
Ha, I.2
Ruvkun, G.3
-
51
-
-
1242296375
-
miRNP:mRNA association in polyribosomes in a human neuronal cell line
-
Nelson, P. T., Hatzigeorgiou, A. G. & Mourelatos, Z. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10, 387-394 (2004).
-
(2004)
RNA
, vol.10
, pp. 387-394
-
-
Nelson, P.T.1
Hatzigeorgiou, A.G.2
Mourelatos, Z.3
-
52
-
-
0346458628
-
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
-
Kim, J. et al. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl Acad. Sci. USA 101, 360-365 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 360-365
-
-
Kim, J.1
-
53
-
-
0037144546
-
A microRNA in a multiple-turnover RNAi enzyme complex
-
Hutvágner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
-
(2002)
Science
, vol.297
, pp. 2056-2060
-
-
Hutvágner, G.1
Zamore, P.D.2
-
55
-
-
24144445346
-
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells
-
Miyagishi, M., Hayashi, M. & Taira, K. Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev. 13, 1-7 (2003).
-
(2003)
Antisense Nucleic Acid Drug Dev.
, vol.13
, pp. 1-7
-
-
Miyagishi, M.1
Hayashi, M.2
Taira, K.3
-
56
-
-
0042161890
-
The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides
-
Kretschmer-Kazemi Far, R. & Sczakiel, G. The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides. Nucleic Acids Res. 31, 4417-4424 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 4417-4424
-
-
Kretschmer-Kazemi Far, R.1
Sczakiel, G.2
-
57
-
-
0038578021
-
Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA
-
Grunweller, A. et al. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′ -O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 31, 3185-3193 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 3185-3193
-
-
Grunweller, A.1
-
58
-
-
0041630618
-
Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs
-
Xu, Y. et al. Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs. Biochem. Biophys. Res. Commun. 306, 712-717 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 712-717
-
-
Xu, Y.1
-
59
-
-
0037470145
-
Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis
-
Vickers, T. A. et al. Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J. Biol. Chem. 278, 7108-7118 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7108-7118
-
-
Vickers, T.A.1
-
60
-
-
0036385852
-
Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo
-
Bertrand, J. R. et al. Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. Biochem. Biophys. Res. Commun. 296, 1000-1004 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 1000-1004
-
-
Bertrand, J.R.1
-
61
-
-
10744225153
-
Asymmetry in the assembly of the RNAi enzyme complex
-
Schwarz, D. S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208 (2003).
-
(2003)
Cell
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
-
62
-
-
0142165224
-
Functional siRNAs and miRNAs exhibit strand bias
-
Khvorova, A., Reynolds, A. & Jayasena, S. D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216 (2003).
-
(2003)
Cell
, vol.115
, pp. 209-216
-
-
Khvorova, A.1
Reynolds, A.2
Jayasena, S.D.3
-
63
-
-
24344500241
-
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
-
Harborth, J. et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev. 13, 83-105 (2003).
-
(2003)
Antisense Nucleic Acid Drug Dev.
, vol.13
, pp. 83-105
-
-
Harborth, J.1
-
64
-
-
1242352936
-
Efficient and isoform-selective inhibition of cellular gene expression by peptide nucleic acids
-
Liu, Y., Braasch, D. A., Nulf, C. J. & Corey, D. R. Efficient and isoform-selective inhibition of cellular gene expression by peptide nucleic acids. Biochemisty 43, 1921-1927 (2004).
-
(2004)
Biochemisty
, vol.43
, pp. 1921-1927
-
-
Liu, Y.1
Braasch, D.A.2
Nulf, C.J.3
Corey, D.R.4
-
65
-
-
0034015113
-
Phosphorothioate oligodeoxynucleotides: What is their origin and what is unique about them?
-
Eckstein, F. Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them? Antisense Nucleic Acid Drug Dev. 10, 117-121 (2000).
-
(2000)
Antisense Nucleic Acid Drug Dev.
, vol.10
, pp. 117-121
-
-
Eckstein, F.1
-
66
-
-
9144256376
-
siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme
-
Yokota, T. et al. siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem. Biophys. Res. Commun. 314, 283-291 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.314
, pp. 283-291
-
-
Yokota, T.1
-
67
-
-
0036256430
-
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
-
Lee, N. S. et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nature Biotechnol. 20, 500-505 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 500-505
-
-
Lee, N.S.1
-
68
-
-
0033571083
-
RNA hairpin loops repress protein synthesis more strongly than hammerhead ribozymes
-
Drew, H. R. et al. RNA hairpin loops repress protein synthesis more strongly than hammerhead ribozymes. Eur. J. Biochem. 208, 260-273 (1999).
-
(1999)
Eur. J. Biochem.
, vol.208
, pp. 260-273
-
-
Drew, H.R.1
-
69
-
-
0035028575
-
Antisense of oligonucleotides: Promise and reality
-
Lebedeva, I. & Stein, C. A. Antisense of oligonucleotides: promise and reality. Annu. Rev. Pharmacol. Toxicol. 41, 403-419 (2001).
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 403-419
-
-
Lebedeva, I.1
Stein, C.A.2
-
70
-
-
0035878848
-
Antimetastatic effect of CpG DNA mediated by type I IFN
-
Hafner, M. et al. Antimetastatic effect of CpG DNA mediated by type I IFN. Cancer Res. 61, 5523-6528 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 5523-6528
-
-
Hafner, M.1
-
71
-
-
0030764558
-
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
-
Roman, M. et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Med. 3, 849-854 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 849-854
-
-
Roman, M.1
-
72
-
-
0038814164
-
Recent advances in immunostimulatory CpG oligonucleotides
-
Rothenfusser, S., Tuma, E., Wagner, M., Endres, S. & Hartmann, G. Recent advances in immunostimulatory CpG oligonucleotides. Curr. Opin. Mol. Ther. 5, 98-106 (2003).
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, pp. 98-106
-
-
Rothenfusser, S.1
Tuma, E.2
Wagner, M.3
Endres, S.4
Hartmann, G.5
-
73
-
-
0036168035
-
Antisense and sensibility
-
Dove, A. Antisense and sensibility. Nature Biotechnol. 20, 121-124 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 121-124
-
-
Dove, A.1
-
74
-
-
1042275580
-
G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner
-
Lai, J. C. et al. G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner. Mol. Cancer Ther. 2, 1031-1043 (2003).
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 1031-1043
-
-
Lai, J.C.1
-
75
-
-
0027370258
-
Protein enhancement of hammerhead ribozyme catalysts
-
Tsuchihashi, Z., Khosla, M. & Herschlag, D. Protein enhancement of hammerhead ribozyme catalysts. Science 262, 99-102 (1993).
-
(1993)
Science
, vol.262
, pp. 99-102
-
-
Tsuchihashi, Z.1
Khosla, M.2
Herschlag, D.3
-
76
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
-
Heil, F. et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
-
77
-
-
1542317550
-
Innate antiviral responses by means of TLR7-Mediated recognition of single-stranded RNA
-
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-Mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis e Sousa, C.5
-
78
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson, A. L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nature Biotechnol. 21, 635-637 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
-
79
-
-
0038798081
-
Genomewide view of gene silencing by small interfering RNAs
-
Chi, J. T. et al. Genomewide view of gene silencing by small interfering RNAs. Proc. Natl Acad. Sci. USA 100, 6343-6346 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6343-6346
-
-
Chi, J.T.1
-
80
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov, D. et al. Specificity of short interfering RNA determined through gene expression signatures. Proc. Natl Acad. Sci. USA 100, 6347-6352 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
-
81
-
-
0347623204
-
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
-
Persengiev, S. P., Zhu, X. & Green, M. R. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10, 12-18 (2004).
-
(2004)
RNA
, vol.10
, pp. 12-18
-
-
Persengiev, S.P.1
Zhu, X.2
Green, M.R.3
-
82
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz, C. A., Holko, M., de Veer, M. J., Silverman, R. H. & Williams, B. R. Activation of the interferon system by short-interfering RNAs. Nature Cell Biol. 5, 834-839 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
Silverman, R.H.4
Williams, B.R.5
-
83
-
-
0038419800
-
Induction of an interferon response by RNAi vectors in mammalian cells
-
Bridge, A. J., Pebernard, S., Ducraux, A., Nicoulaz, A. L. & Iggo, R. Induction of an interferon response by RNAi vectors in mammalian cells. Nature Genet. 34, 263-264 (2003).
-
(2003)
Nature Genet.
, vol.34
, pp. 263-264
-
-
Bridge, A.J.1
Pebernard, S.2
Ducraux, A.3
Nicoulaz, A.L.4
Iggo, R.5
-
84
-
-
0026588983
-
Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures
-
Giles, R. V. & Tidd, D. M. Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures. Nucleic Acids Res. 20, 763-770 (1992).
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 763-770
-
-
Giles, R.V.1
Tidd, D.M.2
-
85
-
-
0027168725
-
Evaluation of 2′-modified oligonucleotides; containing 2′-deoxy gaps as antisense inhibitors of gene expression
-
Monia, B. P. et al. Evaluation of 2′-modified oligonucleotides; containing 2′-deoxy gaps as antisense inhibitors of gene expression. J. Biol. Chem. 258, 14514-14522 (1993).
-
(1993)
J. Biol. Chem.
, vol.258
, pp. 14514-14522
-
-
Monia, B.P.1
-
86
-
-
0142173075
-
Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
-
Saxena, S., Jonsson, Z. O. & Dutta, A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J. Biol. Chem. 278, 44312-44319 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44312-44319
-
-
Saxena, S.1
Jonsson, Z.O.2
Dutta, A.3
-
87
-
-
0037443089
-
siRNAs can function as miRNAs
-
Doench, J. G., Petersen, C. P. & Sharp, P. A. siRNAs can function as miRNAs. Genes Dev. 17, 438-442 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 438-442
-
-
Doench, J.G.1
Petersen, C.P.2
Sharp, P.A.3
-
88
-
-
0041691111
-
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
-
Zeng, Y., Yi, R. & Cullen, B. R. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100, 9779-9784 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9779-9784
-
-
Zeng, Y.1
Yi, R.2
Cullen, B.R.3
-
89
-
-
0037804642
-
Whither RNAi?
-
Editorial
-
Editorial. Whither RNAi? Nature Cell Biol. 5, 489-490 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 489-490
-
-
-
90
-
-
0035694237
-
Identification of essential genes in cultured mammalian cells using small interfering RNAs
-
Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T. & Weber, K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 114, 4557-4565 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 4557-4565
-
-
Harborth, J.1
Elbashir, S.M.2
Bechert, K.3
Tuschl, T.4
Weber, K.5
-
91
-
-
0038132996
-
Allele-specific silencing of dominant disease genes
-
Miller, V. M. et al. Allele-specific silencing of dominant disease genes. Proc. Natl Acad. Sci. USA 100, 7195-7200 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7195-7200
-
-
Miller, V.M.1
-
92
-
-
0242379146
-
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
-
Ding, H. et al. Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell 2, 209-217 (2003).
-
(2003)
Aging Cell
, vol.2
, pp. 209-217
-
-
Ding, H.1
-
93
-
-
0141886425
-
Allele-specific silencing of a pathogenic mutant acetylcholine receptor subunit by RNA interference
-
Abdelgany, A., Wood, M. & Beeson, D. Allele-specific silencing of a pathogenic mutant acetylcholine receptor subunit by RNA interference. Hum. Mol. Genet. 12, 2637-2644 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2637-2644
-
-
Abdelgany, A.1
Wood, M.2
Beeson, D.3
-
94
-
-
0038443032
-
Toward therapy for DYT1 dystonia: Allele-specific silencing of mutant TorsinA
-
Gonzalez-Alegre, P., Miller, V. M., Davidson, B. L. & Paulson, H. L. Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA. Ann. Neurol. 53, 781-787 (2003).
-
(2003)
Ann. Neurol.
, vol.53
, pp. 781-787
-
-
Gonzalez-Alegre, P.1
Miller, V.M.2
Davidson, B.L.3
Paulson, H.L.4
-
95
-
-
0036245743
-
Expanding small RNA interference
-
Tuschl, T. Expanding small RNA interference. Nature Biotechnol. 20, 446-448 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 446-448
-
-
Tuschl, T.1
-
96
-
-
0036787671
-
siRNA-mediated gene silencing in vitro and in vivo
-
Xia, H., Mao, Q., Paulson, H. L. & Davidson, B. L. siRNA-mediated gene silencing in vitro and in vivo. Nature Biotechnol. 20, 1006-1010 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.L.3
Davidson, B.L.4
-
97
-
-
10744221455
-
Adenoviral vectors expressing siRNAs for discovery and validation of gene function
-
Arts, G. J. et al. Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome. Res. 13, 2325-2332 (2003).
-
(2003)
Genome. Res.
, vol.13
, pp. 2325-2332
-
-
Arts, G.J.1
-
98
-
-
0037468660
-
Gene silencing by adenovirus-delivered siRNA
-
Shen, C., Buck, A. K., Liu, X., Winkler, M. & Reske, S. N. Gene silencing by adenovirus-delivered siRNA. FEBS Lett. 539, 111-114 (2003).
-
(2003)
FEBS Lett.
, vol.539
, pp. 111-114
-
-
Shen, C.1
Buck, A.K.2
Liu, X.3
Winkler, M.4
Reske, S.N.5
-
99
-
-
0141991324
-
Specific gene inhibition by adenovirus-mediated expression of small interfering RNA
-
Zhao, L. J., Jian, H. & Zhu, H. Specific gene inhibition by adenovirus-mediated expression of small interfering RNA. Gene 316, 137-141 (2003).
-
(2003)
Gene
, vol.316
, pp. 137-141
-
-
Zhao, L.J.1
Jian, H.2
Zhu, H.3
-
100
-
-
0042838272
-
Use of adeno-associated viral vector for delivery of small interfering RNA
-
Tomar, R. S., Matta, H. & Chaudhary, P. M. Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene 22, 5712-5715 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 5712-5715
-
-
Tomar, R.S.1
Matta, H.2
Chaudhary, P.M.3
-
101
-
-
0346216853
-
Local gene knockdown in the brain using viral-mediated RNA interference
-
Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L. & DiLeone, R. J. Local gene knockdown in the brain using viral-mediated RNA interference. Nature Med. 9, 1539-1544 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1539-1544
-
-
Hommel, J.D.1
Sears, R.M.2
Georgescu, D.3
Simmons, D.L.4
DiLeone, R.J.5
-
102
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Brummelkamp, T. R., Bernards, R. & Agami, R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2, 243-247 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
103
-
-
0043210428
-
Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
-
Wiznerowicz, M. & Trono, D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J. Virol. 77, 8957-8961 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 8957-8961
-
-
Wiznerowicz, M.1
Trono, D.2
-
104
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic, mice by RNA interference
-
Rubinson, D. A. et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic, mice by RNA interference. Nature Genet. 33, 401-406 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 401-406
-
-
Rubinson, D.A.1
-
105
-
-
0042267194
-
Efficient lentiviral vectors for short hairpin RNA delivery into human cells
-
An, D. S. et al. Efficient lentiviral vectors for short hairpin RNA delivery into human cells. Hum. Gene Ther. 14, 1207-1212 (2003).
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 1207-1212
-
-
An, D.S.1
-
106
-
-
10744219596
-
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
-
van de Wetering, M. et al. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 4, 609-615 (2003).
-
(2003)
EMBO Rep.
, vol.4
, pp. 609-615
-
-
van de Wetering, M.1
-
107
-
-
0642303887
-
Inducible shRNA expression for application in a prostate cancer mouse model
-
Czauderna, F. et al. Inducible shRNA expression for application in a prostate cancer mouse model. Nucleic Acids Res. 31, e127 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
-
-
Czauderna, F.1
-
108
-
-
0042662862
-
Establishment of conditional vectors for hairpin siRNA knockdowns
-
Matsukura, S., Jones, P. A. & Takai, D. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Res. 31, e77 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
-
-
Matsukura, S.1
Jones, P.A.2
Takai, D.3
-
109
-
-
0037948173
-
Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter
-
Shinagawa, T. & Ishii, S. Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. Genes Dev. 17, 1340-1346 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1340-1346
-
-
Shinagawa, T.1
Ishii, S.2
-
110
-
-
0347089037
-
Electroporation and RNA interference in the rodent retina in vivo and in vitro
-
Matsuda, T. & Cepko, C. L. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc. Natl Acad. Sci. USA 101, 16-22 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 16-22
-
-
Matsuda, T.1
Cepko, C.L.2
-
111
-
-
0036806941
-
Spatial and temporal 'knock down' of gone expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos
-
Mellitzer, G., Hallonet, M., Chen, L. & Ang, S. Spatial and temporal 'knock down' of gone expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos. Mech. Dev. 118, 57 (2002).
-
(2002)
Mech. Dev.
, vol.118
, pp. 57
-
-
Mellitzer, G.1
Hallonet, M.2
Chen, L.3
Ang, S.4
-
112
-
-
0344395644
-
RNAi reveals doublecortin is required for radial migration in rat neocortex
-
Bai, J. et al. RNAi reveals doublecortin is required for radial migration in rat neocortex. Nature Neurosci. 6, 1277-1283 (2003).
-
(2003)
Nature Neurosci.
, vol.6
, pp. 1277-1283
-
-
Bai, J.1
-
113
-
-
0037195064
-
Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA
-
Calegari, F., Haubensak, W., Yang, D., Huttner, W. B. & Buchholz, F. Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc. Natl Acad. Sci. USA 99, 14236-14240 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14236-14240
-
-
Calegari, F.1
Haubensak, W.2
Yang, D.3
Huttner, W.B.4
Buchholz, F.5
-
114
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich, S. J. et al. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol. Vis. 9, 210-216 (2003).
-
(2003)
Mol. Vis.
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
-
115
-
-
0141552295
-
Gene silencing by systemic delivery of synthetic siRNAs in adult mice
-
Sorensen, D. R., Leirdal, M. & Sioud, M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J. Mol. Biol. 327, 761-766 (2003).
-
(2003)
J. Mol. Biol.
, vol.327
, pp. 761-766
-
-
Sorensen, D.R.1
Leirdal, M.2
Sioud, M.3
-
116
-
-
1642487117
-
Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference
-
Kong, X. C., Barzaghi, P. & Ruegg, M. A. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. EMBO Rep. 5, 183-188 (2004).
-
(2004)
EMBO Rep.
, vol.5
, pp. 183-188
-
-
Kong, X.C.1
Barzaghi, P.2
Ruegg, M.A.3
-
117
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey, A. P. et al. RNA interference in adult mice. Nature 418, 38-39 (2002).
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
-
118
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis, D. L., Hagstrom, J. E., Loomis, A. G., Wolff, J. A. & Herweijer, H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nature Genet. 32, 107-108 (2002).
-
(2002)
Nature Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
-
119
-
-
0346873025
-
Small interfering RNA inhibits hepatitis B virus replication in mice
-
Giladi, H. et al. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol. Ther. 8, 769-776 (2003).
-
(2003)
Mol. Ther.
, vol.8
, pp. 769-776
-
-
Giladi, H.1
-
120
-
-
0038449221
-
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
-
Klein, C. et al. Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 125, 9-18 (2003).
-
(2003)
Gastroenterology
, vol.125
, pp. 9-18
-
-
Klein, C.1
-
121
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender, L. et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl Acad. Sci. USA 100, 7797-7802 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
-
122
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song, E. et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nature Med. 9, 347-351 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 347-351
-
-
Song, E.1
-
123
-
-
0038023197
-
Inhibition of hepatitis B virus in mice by RNA interference
-
McCaffrey, A. P. et al. Inhibition of hepatitis B virus in mice by RNA interference. Nature Biotechnol. 21, 639-644 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 639-644
-
-
McCaffrey, A.P.1
-
124
-
-
0037062920
-
Emerging clinical applications of RNA
-
Sullenger, B. A. & Gilboa, E. Emerging clinical applications of RNA. Nature 418, 252-258 (2002).
-
(2002)
Nature
, vol.418
, pp. 252-258
-
-
Sullenger, B.A.1
Gilboa, E.2
-
125
-
-
0242636380
-
Dissecting HIV-1 through RNA interference
-
Stevenson, M. Dissecting HIV-1 through RNA interference. Nature Rev. Immunol. 3, 851-858 (2003).
-
(2003)
Nature Rev. Immunol.
, vol.3
, pp. 851-858
-
-
Stevenson, M.1
-
126
-
-
0036636074
-
Nucleic-acid therapeutics: Basic principles and recent applications
-
Opalinska, J. B. & Gewirtz, A. M. Nucleic-acid therapeutics: basic principles and recent applications. Nature Rev. Drug Discov. 1, 503-514 (2002).
-
(2002)
Nature Rev. Drug Discov.
, vol.1
, pp. 503-514
-
-
Opalinska, J.B.1
Gewirtz, A.M.2
-
127
-
-
0037308205
-
The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis
-
Brenner, T. et al. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB J. 17, 214-222 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 214-222
-
-
Brenner, T.1
-
128
-
-
0035119622
-
Absolute bioavailability, of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats
-
Geary, R. S. et al. Absolute bioavailability, of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats. J. Pharmacol. Exp. Ther. 296, 898-904 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 898-904
-
-
Geary, R.S.1
-
129
-
-
0038122882
-
Success for oral antisense therapy
-
Sussman, H. E. Success for oral antisense therapy. Drug. Discov. Today 8, 516-517 (2003).
-
(2003)
Drug Discov. Today
, vol.8
, pp. 516-517
-
-
Sussman, H.E.1
-
130
-
-
0742288421
-
Discovery of transdermal penetration enhancers by high-throughput screening
-
Karande, P., Jain, A. & Mitragotri, S. Discovery of transdermal penetration enhancers by high-throughput screening. Nature Biotechnol. 22, 192-197 (2004).
-
(2004)
Nature Biotechnol.
, vol.22
, pp. 192-197
-
-
Karande, P.1
Jain, A.2
Mitragotri, S.3
-
131
-
-
85047676333
-
Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery
-
Gautam, A., Densmore, C. L., Xu, B. & Waldrep, J. C. Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery. Mol. Ther. 2, 63-70 (2000).
-
(2000)
Mol. Ther.
, vol.2
, pp. 63-70
-
-
Gautam, A.1
Densmore, C.L.2
Xu, B.3
Waldrep, J.C.4
-
132
-
-
0037312978
-
Germline transmission of RNAi in mice
-
Carmell, M. A., Zhang, L., Conklin, D. S., Hannon, G. J. & Rosenquist, T. A. Germline transmission of RNAi in mice. Nature Struct. Biol. 10, 91-92 (2003)
-
(2003)
Nature Struct. Biol.
, vol.10
, pp. 91-92
-
-
Carmell, M.A.1
Zhang, L.2
Conklin, D.S.3
Hannon, G.J.4
Rosenquist, T.A.5
-
133
-
-
0037370309
-
An epi-allelic, series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
-
Hemann, M. T. et al. An epi-allelic, series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nature Genet. 33, 396-400 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 396-400
-
-
Hemann, M.T.1
-
134
-
-
1642514813
-
Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
-
Davies, J. A. et al. Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation. Hum. Mol. Genet. 13, 235-246 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.13
, pp. 235-246
-
-
Davies, J.A.1
-
135
-
-
0346728473
-
Systematic genome-wide screens of gene function
-
Carpenter, A. E. & Sabatini, D. M. Systematic genome-wide screens of gene function. Nature Rev. Genet. 5, 11-22 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 11-22
-
-
Carpenter, A.E.1
Sabatini, D.M.2
-
136
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans, genome using RNAi
-
Kamath, R. S. et al. Systematic functional analysis of the Caenorhabditis elegans, genome using RNAi. Nature 421, 231-237 (2003).
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
-
137
-
-
0037448528
-
Genome-wide RNA analysis of Caenorhabditis elegans fat regulatory genes
-
Ashrafi, K. et al. Genome-wide RNA analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272 (2003).
-
(2003)
Nature
, vol.421
, pp. 268-272
-
-
Ashrafi, K.1
-
138
-
-
0034676457
-
Functional genomic, analysis of C. elegans, chromosome I by systematic RNA interference
-
Fraser, A. G. et al. Functional genomic, analysis of C. elegans, chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
-
139
-
-
0034676448
-
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
-
Gonczy P., et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331-336 (2000).
-
(2000)
Nature
, vol.408
, pp. 331-336
-
-
Gonczy, P.1
-
140
-
-
0035128859
-
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
-
Maeda, I., Kohara, Y., Yamamoto, M. & Sugimoto, A. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr. Biol. 11, 171-176 (2001).
-
(2001)
Curr. Biol.
, vol.11
, pp. 171-176
-
-
Maeda, I.1
Kohara, Y.2
Yamamoto, M.3
Sugimoto, A.4
-
141
-
-
0037137443
-
Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans
-
Piano, F. et al. Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans. Curr. Biol. 12, 1959-19564 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1959-19564
-
-
Piano, F.1
-
142
-
-
0034649570
-
RNAi analysis of genes expressed in the ovary of Caenorhabditis, elegans
-
Piano, F., Schetter, A. J., Mangone, M., Stein, L. & Kemphues, K. J. RNAi analysis of genes expressed in the ovary of Caenorhabditis, elegans. Curr. Biol. 10, 1619-1622 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1619-1622
-
-
Piano, F.1
Schetter, A.J.2
Mangone, M.3
Stein, L.4
Kemphues, K.J.5
-
143
-
-
1542298437
-
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions
-
Simmer, F., et al. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol. 1, E12 (2003).
-
(2003)
PLoS Biol.
, vol.1
-
-
Simmer, F.1
-
144
-
-
0043202980
-
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans
-
Vastenhouw, N. L. et al. A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr. Biol. 13, 1311-1316 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 1311-1316
-
-
Vastenhouw, N.L.1
-
145
-
-
0037443054
-
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi
-
Pothrof, J. et al. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev. 117, 443-448 (2003).
-
(2003)
Genes Dev.
, vol.117
, pp. 443-448
-
-
Pothrof, J.1
-
146
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee, S. S. et al. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genet. 33, 40-48 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
-
147
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
Lum, L. et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039-2045 (2003).
-
(2003)
Science
, vol.299
, pp. 2039-2045
-
-
Lum, L.1
-
148
-
-
0242361514
-
A functional genomic analysis of cell morphology using RNA interference
-
Kiger, A. et al. A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2, 27 (2003).
-
(2003)
J. Biol.
, vol.2
, pp. 27
-
-
Kiger, A.1
-
149
-
-
0842309871
-
Genome-wide RNAi analysis of growth and viability in Drosophila cells
-
Boutros, M. et al. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303, 832-835 (2004).
-
(2004)
Science
, vol.303
, pp. 832-835
-
-
Boutros, M.1
-
150
-
-
0031415029
-
Random mutagenesis screen for dominant behavioral mutations in mice
-
Nolan, P. M., Kapfhamer, D. & Bucan, M. Random mutagenesis screen for dominant behavioral mutations in mice. Methods 13, 379-395 (1997).
-
(1997)
Methods
, vol.13
, pp. 379-395
-
-
Nolan, P.M.1
Kapfhamer, D.2
Bucan, M.3
-
151
-
-
0032924464
-
N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations
-
Rinchik, E. M. & Carpenter, D. A. N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations. Genetics 152, 373-383 (1999).
-
(1999)
Genetics
, vol.152
, pp. 373-383
-
-
Rinchik, E.M.1
Carpenter, D.A.2
-
152
-
-
0034425410
-
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
-
Nolan, P. M. et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nature Genet. 25, 440-443 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 440-443
-
-
Nolan, P.M.1
-
153
-
-
0034425715
-
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
-
Hrabe de Angelis, M. H. et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genet. 25, 444-447 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 444-447
-
-
Hrabe de Angelis, M.H.1
-
154
-
-
0042911521
-
Functional genetic analysis of mouse chromosome 11
-
Kile, B. T. et al. Functional genetic analysis of mouse chromosome 11. Nature 425, 81-86 (2003).
-
(2003)
Nature
, vol.425
, pp. 81-86
-
-
Kile, B.T.1
-
155
-
-
0034254815
-
Too much interference: Injection of double-stranded RNA has nonspecific effects in the zebrafish embryo
-
Oates, A. C., Bruce, A. E. & Ho, R. K. Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo. Dev. Biol. 224, 20-28 (2000).
-
(2000)
Dev. Biol.
, vol.224
, pp. 20-28
-
-
Oates, A.C.1
Bruce, A.E.2
Ho, R.K.3
-
156
-
-
0037423845
-
Vertebrate microRNA genes
-
Lim, L. P., Glasner, M. E., Yeka, S., Burge, C. B. & Bartel, D. P. Vertebrate microRNA genes. Science 299, 1540 (2003).
-
(2003)
Science
, vol.299
, pp. 1540
-
-
Lim, L.P.1
Glasner, M.E.2
Yeka, S.3
Burge, C.B.4
Bartel, D.P.5
-
157
-
-
0036529570
-
Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNAs
-
Zhou, Y., Ching, Y.-P., Kok, K. H., Kung, H. & Jin, D.-J. Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNAs. Nucleic Acids Res. 30, 1664-1669 (2002).
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 1664-1669
-
-
Zhou, Y.1
Ching, Y.-P.2
Kok, K.H.3
Kung, H.4
Jin, D.-J.5
-
158
-
-
0037227960
-
Screening for gene function in chicken embryo using RNAi and electroporation
-
Pekarik, V. et al. Screening for gene function in chicken embryo using RNAi and electroporation. Nature Biotechnol. 21, 93-96 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 93-96
-
-
Pekarik, V.1
-
159
-
-
0033766888
-
Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA inteference
-
Svoboda, P., Stein, P., Hayashi, H. & Schultz, R. M. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA inteference. Development 127, 4147-4156 (2000).
-
(2000)
Development
, vol.127
, pp. 4147-4156
-
-
Svoboda, P.1
Stein, P.2
Hayashi, H.3
Schultz, R.M.4
-
160
-
-
0037377201
-
Transgenic RNAi in mouse oocytes: A simple and fast approach to study gene function
-
Stein, P., Svoboda, P. & Schultz, R. M. Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function. Dev. Biol. 256, 187-193 (2003).
-
(2003)
Dev. Biol.
, vol.256
, pp. 187-193
-
-
Stein, P.1
Svoboda, P.2
Schultz, R.M.3
-
161
-
-
0141750434
-
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
-
Aza-Blanc, P. et al. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627-637 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 627-637
-
-
Aza-Blanc, P.1
-
162
-
-
0347089019
-
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells
-
Zheng, L. et al. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc. Natl Acad. Sci. USA 101, 135-140 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 135-140
-
-
Zheng, L.1
-
163
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
-
Brummelkamp, T. R., Nijman, S. M., Dirac, A. M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003).
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
164
-
-
85039536669
-
A large-scale RNAi screen in human cells identifies novel components of the p53 pathway
-
(in the press)
-
Berns, K. et al. A large-scale RNAi screen in human cells identifies novel components of the p53 pathway. Nature (in the press).
-
Nature
-
-
Berns, K.1
-
165
-
-
0036975958
-
The effectiveness of double-stranded short inhibitory RNAs (siRNAs) may depend on the method of transfection
-
Walters, D. K. & Jelinek, D. F. The effectiveness of double-stranded short inhibitory RNAs (siRNAs) may depend on the method of transfection. Antisense Nucleic Acid Drug Dev. 12, 411-418 (2002).
-
(2002)
Antisense Nucleic Acid Drug Dev.
, vol.12
, pp. 411-418
-
-
Walters, D.K.1
Jelinek, D.F.2
-
166
-
-
0347928860
-
Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells
-
Weil, D. et al. Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells. Biotechniques 33, 1244-1248 (2002).
-
(2002)
Biotechniques
, vol.33
, pp. 1244-1248
-
-
Weil, D.1
-
167
-
-
0037417136
-
Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference
-
Zhou, A., Scoggin, S., Gaynor, R. B. & Williams, N. S. Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference. Oncogene 22, 2054-2064 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 2054-2064
-
-
Zhou, A.1
Scoggin, S.2
Gaynor, R.B.3
Williams, N.S.4
-
168
-
-
0037343270
-
Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference
-
Williams, N. S. et al. Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference. Clin. Cancer Res. 9, 931-946 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 931-946
-
-
Williams, N.S.1
-
169
-
-
0035799654
-
Microarrays of cells expressing defined cDNAs
-
Ziauddin, J. & Sabatini, D. M. Microarrays of cells expressing defined cDNAs. Nature 411, 107-110 (2001).
-
(2001)
Nature
, vol.411
, pp. 107-110
-
-
Ziauddin, J.1
Sabatini, D.M.2
-
170
-
-
0037107034
-
Applications of transfected cell microarrays in high-throughput drug discovery
-
Bailey, S. N., Wu, R. Z. & Sabatini, D. M. Applications of transfected cell microarrays in high-throughput drug discovery. Drug Discov. Today 7, S113-S118 (2002).
-
(2002)
Drug Discov. Today
, vol.7
-
-
Bailey, S.N.1
Wu, R.Z.2
Sabatini, D.M.3
-
171
-
-
10744230287
-
RNAi microarray analysis in cultured mammalian cells
-
Mousses, S. et al. RNAi microarray analysis in cultured mammalian cells. Genome Res 13, 2341-2347 (2003).
-
(2003)
Genome Res.
, vol.13
, pp. 2341-2347
-
-
Mousses, S.1
-
172
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds, A. et al. Rational siRNA design for RNA interference. Nature Biotechnol. 22, 326-330 (2004).
-
(2004)
Nature Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
-
173
-
-
1642491747
-
Enhancement of RNAi activity by improved siRNA duplexes
-
Hohjoh, H. Enhancement of RNAi activity by improved siRNA duplexes. FEBS Lett. 557, 193-198 (2004).
-
(2004)
FEBS Lett.
, vol.557
, pp. 193-198
-
-
Hohjoh, H.1
-
174
-
-
0344394958
-
Free energy lights the path toward more effective RNAi
-
Silva, J. M., Sachidanandam, R. & Hannon, G. J. Free energy lights the path toward more effective RNAi. Nature Genet. 35, 303-305 (2003).
-
(2003)
Nature Genet.
, vol.35
, pp. 303-305
-
-
Silva, J.M.1
Sachidanandam, R.2
Hannon, G.J.3
-
175
-
-
0036351317
-
Analysis of gene function in somatic mammalian cells using small interfering RNAs
-
Elbashir, S. M., Harborth, J., Weber, K. & Tuschl, T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26, 199-213 (2002).
-
(2002)
Methods
, vol.26
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
176
-
-
0842332405
-
Enzymatic production of RNAi libraries from cDNAs
-
Shirane, D. et al. Enzymatic production of RNAi libraries from cDNAs. Nature Genet 36, 190-196 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 190-196
-
-
Shirane, D.1
-
177
-
-
0842310832
-
Restriction enzyme-generated siRNA (REGS) vectors and libraries
-
Sen, G., Wehrman, T. S., Myers, J. W. & Blau, H. M. Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genet. 35, 183-189 (2004).
-
(2004)
Nature Genet.
, vol.35
, pp. 183-189
-
-
Sen, G.1
Wehrman, T.S.2
Myers, J.W.3
Blau, H.M.4
-
178
-
-
0037327444
-
siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells
-
Kawasaki, H., Suyama, E., Iyo, M. & Taira, K. siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res. 31, 981-987 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 981-987
-
-
Kawasaki, H.1
Suyama, E.2
Iyo, M.3
Taira, K.4
-
179
-
-
0348014778
-
Unlocking the money-making potential of RNAi
-
Howard, K. Unlocking the money-making potential of RNAi. Nature Biotechnol. 21, 1441-1446 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1441-1446
-
-
Howard, K.1
-
180
-
-
0037663944
-
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages
-
Song, E. et al. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J. Virol. 77, 7174-7181 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 7174-7181
-
-
Song, E.1
-
181
-
-
0042173218
-
SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth
-
Filleur, S. et al. SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res. 63, 3919-3922 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 3919-3922
-
-
Filleur, S.1
-
182
-
-
0041335551
-
Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer
-
Yang, G., Thompson, J. A., Fang, B. & Liu, J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene 22, 5694-5701 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 5694-5701
-
-
Yang, G.1
Thompson, J.A.2
Fang, B.3
Liu, J.4
-
183
-
-
0038756442
-
Use of RNA inteference to target cyclin E-overexpressing hepatocellular carcinoma
-
Li, K., Lin, S. Y., Brunicardi, F. C. & Seu, P. Use of RNA inteference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res. 83, 3593-3597 (2003).
-
(2003)
Cancer Res.
, vol.83
, pp. 3593-3597
-
-
Li, K.1
Lin, S.Y.2
Brunicardi, F.C.3
Seu, P.4
-
184
-
-
0037388638
-
Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells
-
Verma, U. N., Surabhi, R. M., Schmaltieg, A., Becerra, C. & Gaynor, R. B. Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin. Cancer. Res. 9, 1291-1300 (2003).
-
(2003)
Clin. Cancer. Res.
, vol.9
, pp. 1291-1300
-
-
Verma, U.N.1
Surabhi, R.M.2
Schmaltieg, A.3
Becerra, C.4
Gaynor, R.B.5
-
185
-
-
0348133602
-
In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA
-
Yoshinouchi, M. et al. In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA. Mol. Ther. 8, 762-768 (2003).
-
(2003)
Mol. Ther.
, vol.8
, pp. 762-768
-
-
Yoshinouchi, M.1
-
186
-
-
0026337408
-
Kinetic characterization of ribonucleases-resistant 2′-modified hammerhead ribozymes
-
Pieken, W. A., Olsen, D. B., Benseler, F., Aurup, H. & Eckstein, F. Kinetic characterization of ribonucleases-resistant 2′-modified hammerhead ribozymes. Science 253, 314-317 (1991).
-
(1991)
Science
, vol.253
, pp. 314-317
-
-
Pieken, W.A.1
Olsen, D.B.2
Benseler, F.3
Aurup, H.4
Eckstein, F.5
-
187
-
-
0028858581
-
Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance
-
Beigelman, L. et al. Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J. Biol. Chem. 270, 25702-25708 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25702-25708
-
-
Beigelman, L.1
-
188
-
-
0032697942
-
A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
-
Levin, A. A. A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta 1489, 69-84 (1999).
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 69-84
-
-
Levin, A.A.1
-
189
-
-
0038606999
-
Structural variations and stabilising modificatons of synthetic siRNAs in mammalian cells
-
Czauderna, F. et al. Structural variations and stabilising modificatons of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 31, 2705-2716 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2705-2716
-
-
Czauderna, F.1
-
190
-
-
0041331496
-
siRNA function in RNAi: A chemical modification analysis
-
Chiu, Y. L. & Rana, T. M. siRNA function in RNAi: a chemical modification analysis. RNA 9, 1034-1048 (2003).
-
(2003)
RNA
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.L.1
Rana, T.M.2
-
191
-
-
0037440005
-
Tolerance for mutations and chemical modifications in a siRNA
-
Amarzguioui, M., Holen, T., Babaie, E. & Prydz, H. Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res. 31, 589-595 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 589-595
-
-
Amarzguioui, M.1
Holen, T.2
Babaie, E.3
Prydz, H.4
-
192
-
-
0038385504
-
RNA interference in mammalian cells by chemically-modified RNA
-
Braasch, D. A. et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42, 7967-7975 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 7967-7975
-
-
Braasch, D.A.1
-
193
-
-
0036752785
-
RNAi in human cells. Basic structural and functional features of small interfering RNA
-
Chiu, Y. L. & Rana, T. M. RNAi in human cells. Basic structural and functional features of small interfering RNA. Mol. Cell 10, 549-561 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 549-561
-
-
Chiu, Y.L.1
Rana, T.M.2
-
194
-
-
0037089135
-
Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
-
Holen, T., Amarzguioui, M., Wiiger, M. T., Babaie, E. & Prydz, H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 30, 1757-1766 (2002).
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 1757-1766
-
-
Holen, T.1
Amarzguioui, M.2
Wiiger, M.T.3
Babaie, E.4
Prydz, H.5
-
195
-
-
0038074374
-
Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway
-
Holen, T., Amarzguioui, M., Babaie, E. & Prydz, H. Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. Nucleic Acids Res. 31, 2401-2407 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2401-2407
-
-
Holen, T.1
Amarzguioui, M.2
Babaie, E.3
Prydz, H.4
-
196
-
-
0036839458
-
Inhibition of HIV-1 infection by small interfering RNA-mediated RNA inteference
-
Capodici, J., Kariko, K. & Weissman, D. Inhibition of HIV-1 infection by small interfering RNA-mediated RNA inteference. J. Immunol. 169, 5196-5201 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 5196-5201
-
-
Capodici, J.1
Kariko, K.2
Weissman, D.3
|