RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila

Molecular Cell

Volumn 9, Issue 2, 2002, Pages 315-327

  Pal Bhadra, Manika ^a   Bhadra, Utpal ^a   Birchler, James A ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; COMPLEMENTARY RNA; RNA;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME SUBUNIT; GENE FREQUENCY; GENE MUTATION; GENE SILENCING; MULTIGENE FAMILY; NONHUMAN; PROMOTER REGION; RNA TRANSCRIPTION; TRANSGENE;

ZOSTEROPIDAE;

EID: 0036184188     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00440-9     Document Type: Article

References (72)

1. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in Drosophila melanogaster germline
2. Transcriptional and posttranscriptional silencing of rodent alpha (I) collagen by a homologous transcriptionally self silenced transgene
3. Double-stranded RNA as a template for gene silencing
4. Deletions at intervening sequence splice sites in the Alcohol dehydrogenase gene of Drosophila
5. Role for a bidentate ribonuclease in the initiation step of RNA interference
6. Making noise about silence: Repression of repeated genes in animals
7. Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover
8. AGO1 defines a novel locus of Arabidopsis controlling leaf development
9. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the piwi domain
10. Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila
11. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa
12. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
13. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase
14. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation
15. Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch
16. A novel class of evolutionary conserved genes defined by piwi are essential for stem cell self-renewal
17. An RNA-dependent RNA polymerase gene in arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
18. SDE3 encodes an RNA helicase required for posttranscriptional gene silencing in Arabidopsis
19. Posttranscriptional reporter transgene silencing in transgenic tobacco
20. Transgene-mediated cosuppression in the C. elegans germ line
21. RNA interference is mediated by 21- and 22-nucleotide RNAs
22. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
23. RNA-triggered gene silencing
24. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
25. AGO1, QDE-2, and RDE-1 are related proteins required for posttranscriptional gene silencing in plants, quelling in fungi and RNA interference in animals
26. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
27. A novel species of small antisense RNA in posttranscriptional gene silencing
28. An RNA-directed nuclease mediates posttranscriptional gene silencing in Drosophila cells
29. Argonaute2, a link between genetic and biochemical analyses of RNAi
30. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
31. The DNA methylation locus DDM1 is required for maintenance of gene silencing in Arabidopsis
32. Taming of transposable elements by homology-dependent gene silencing
33. De novo methylation and cosuppression induced by a cytoplasmically replicating plant RNA virus
34. RNA-DNA interactions and DNA methylation in posttranscriptional gene silencing
35. RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance
36. Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily
37. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled2 act in the wingless pathway
38. mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner Syndrome Helicase and RNaseD
39. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
40. Identification of novel genes coding for small expressed RNAs
41. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
42. Use of P-element mediated transformation to identify the molecular basis of naturally occurring variants affecting Adh expression in Drosophila melanogaster
43. An extensive class of small RNAs in Caenorhabditis elegans
44. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
45. RNA-based silencing strategies in plants
46. Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans
47. Transcriptional silencing and promoter methylation triggered by double-stranded RNA
48. Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis
49. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
50. DNA methylation and chromatin structure affect transcriptional and posttranscriptional transgene silencing in Arabidopsis
51. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
52. Cosuppression in Drosophila: Gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
53. Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences
54. Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity
55. Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans
56. A DNA target of 30 bp is sufficient for RNA-directed DNA methylation
57. A similarity between viral defense and gene silencing in plants
58. Natural mRNA is required for directing Met-tRNA(f) binding to 40S ribosomal subunits in animal cells: Involvement of Co-eIF-2a in natural mRNA-directed initiation complex formation
59. Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster
60. Female sterile mutations on the second chromosome of Drosophila melanogaster
61. Transcriptional and posttranscriptional gene silencing are mechanistically related
62. Posttranscriptional regulation contributes to Drosophila clock gene mRNA cycling
63. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
64. Targeted mRNA degradation by double-stranded RNA in vitro
65. Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA
66. Replicating satellite RNA induces sequence-specific DNA methylation and truncated transcripts in plants
67. RNA-directed de novo methylation of genomic sequences in plants
68. aubergine enhances oskar translation in the Drosophila ovary
69. Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA helicase
70. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos
71. Rnai: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
72. Molecular cloning and characterization of a rabbit eIF2C protein