A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1489, Issue 1, 1999, Pages 69-84

  Levin, Arthur A ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense; Pharmacokinetics; Phosphorothioate oligonucleotide; Toxicology; Vitravene

Indexed keywords

AFOVIRSEN; ALICAFORSEN; CGP 69846A; FOMIVIRSEN; ISIS 3521; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; TRECOVIRSEN;

ANIMAL EXPERIMENT; CELLULAR DISTRIBUTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG METABOLISM; GENOTOXICITY; HUMAN; IMMUNE RESPONSE; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; REVIEW; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE DISTRIBUTION; TOPICAL DRUG ADMINISTRATION;

ANIMALS; BLOOD COAGULATION; CELLS; COMPLEMENT ACTIVATION; COMPLEMENT FACTOR H; DRUG ADMINISTRATION ROUTES; DRUG DELIVERY SYSTEMS; HAPLORHINI; HUMANS; MICE; MUTAGENICITY TESTS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; PROTEIN BINDING; RATS; RNA; THIONUCLEOTIDES; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0032697942     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(99)00140-2     Document Type: Review

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