RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

Science

Volumn 303, Issue 5658, 2004, Pages 672-676

  Verdel, André ^a   Jia, Songtao ^b   Gerber, Scott ^a   Sugiyama, Tomoyasu ^b   Gygi, Steven ^a   Grewal, Shiv I S ^b   Moazed, Danesh ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS; YEAST;

SILENCING MECHANISM;

RNA;

FUNGAL RNA; PROTEIN; PROTEIN AGO1; RIBONUCLEASE; UNCLASSIFIED DRUG;

RNA;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; EPIGENETICS; GENE SILENCING; GENE TARGETING; HETEROCHROMATIN; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; RNA TRANSCRIPTION; YEAST;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CENTROMERE; CHROMOSOMES, FUNGAL; GENES, REPORTER; HETEROCHROMATIN; MASS SPECTROMETRY; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; RIBONUCLEASE III; RNA INTERFERENCE; RNA, FUNGAL; RNA, SMALL INTERFERING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SCHIZOSACCHAROMYCES POMBE;

EID: 0942279635     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093686     Document Type: Article

References (27)

1. S. I. S. Grewal, J. Cell. Physiol. 184, 311 (2000).
2. S. I. S. Grewal, D. Moazed, Science 301, 798 (2003).
3. J. F. Partridge, K. S. Scott, A. J. Bannister, T. Kouzarides, R. C. Allshire, Curr. Biol. 12, 1652 (2002).
4. D. Zilberman, X. Cao, S. E. Jacobsen, Science 299, 716 (2003).
5. M. Matzke, A. J. M. Matzke, J. M. Kooter, Science 293, 1080 (2001).
6. F. E. Vaistij, L. Jones, D. C. Baulcombe, Plant Cell 14, 857 (2002).
7. M. Pal-Bhadra, U. Bhadra, J. A. Birchler, Mol. Cell 9, 315 (2002).
8. K. Nochizuki, N. A. Fine, T. Fujisawa, M. A. Gorovsky, Cell 110, 689 (2002).
9. T. A. Volpe et al., Science 297, 1833 (2002).
10. I. M. Hall et al., Science 297, 2232 (2002).
11. A. Fire et al., Nature 391, 806 (1998).
12. G. J. Hannon, Nature 418, 244 (2002).
13. P. D. Zamore, Science 296, 1265 (2002).
14. S. M. Hammond, S. Boettcher, A. A. Caudy, R. Kobayashi, G. J. Hannon, Science 293, 1146 (2001).
15. G. Hutvágner, P. D. Zamore, Science 297, 2056 (2002).
16. B. J. Reinhart, D. P. Bartel, Science 297, 1831 (2002).
17. V. Schramke, R. Allshire, Science 301, 1069 (2003).
18. J. F. Partridge, B. Borgstrom, R. C. Allshire, Genes Dev. 14, 783 (2000).
19. G. Thon, J. Verhein-Hansen, Genetics 155, 551 (2000).
20. C. L. Doe et al., Nucleic Acids Res. 26, 4222 (1998).
21. G. D. Shankaranarayana, M. R. Motamedi, D. Moazed, S. I. S. Grewal, Curr. Biol. 13, 1240 (2003).
22. Materials and methods are available as supporting material on Science Online.
23. D. S. Schwarz, G. Hutvágner, B. Haley, P. D. Zamore, Mol. Cell 10, 537 (2002).
24. J. Martinez, A. Patkaniowska, H. Urlaub, R. Luhrmann, T. Tuschl, Cell 110, 563 (2002).
25. S. D. Tavema, R. S. Coyne, C. D. Allis, Cell 110, 701 (2002).
26. J. Nakayama, J. C. Rice, B. D. Strahl, C. D. Allis, S. I. S. Grewal, Science 292, 110 (2001).
27. We thank M. Ohi, K. Gould, C. Hoffman, and D. Wolf for gifts of strains and plasmids; members of the Moazed, Grewal, and Reed laboratories for support and encouragement; R Ohi and El C. Ibrahim for advice; El C. Ibrahim and M. Wahi for comments on the manuscript; and C. Centrella for technical help. A.V. was supported by a postdoctoral fellowship from INSERM and is now a fellow of the Human Frontier Science Programme. This work was supported by grants from the NIH (S.I.S.G. and D.M.) and a Carolyn and Peter S. Lynch Award in Cell Biology and Pathology (D.M.). D.M. is a scholar of the Leukemia and Lymphoma Society.