The chemical repertoire of natural ribozymes

Nature

Volumn 418, Issue 6894, 2002, Pages 222-228

  Doudna, Jennifer A ^a   Cech, Thomas R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; ENZYMES; GENETIC ENGINEERING;

CELLULAR REACTIONS;

RNA;

ESTER DERIVATIVE; RIBOZYME; RNA;

BIOCHEMISTRY; CHEMICAL REACTION; RNA;

ASTRONOMY; CATALYSIS; CATALYST; CELL ACTIVITY; CHEMICAL BINDING; CHEMICAL REACTION; ENZYME ACTIVITY; GENETIC ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

ANIMALS; BIOGENESIS; CATALYSIS; ENDORIBONUCLEASES; HUMANS; INTRONS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RIBONUCLEASE P; RIBONUCLEOPROTEINS; RNA SPLICING; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 0037062949     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/418222a     Document Type: Review

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18. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
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23. Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?
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29. Formation of a stable triplex from a single DNA strand
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34. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
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47. Modelling of the three-dimensional architecture of group 1 catalytic introns based on comparative sequence analysis
48. An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site
49. Kinetic characterization of the second step of group II intron splicing: Role of metal ions and the cleavage site 2′-OH in catalysis
50. Metal ion binding sites in a group II intron core
51. Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis
52. Identification of structural elements critical for inter-domain interactions in a group II self-splicing intron
53. A tertiary interaction that links active-site domains to the 5′ splice site of a group II intron
54. Control of branch-site choice by a group II intron
55. Structural insights into group II intron catalysis and branch-site selection
56. A three-dimensional perspective on exon binding by a group 11 self-splicing intron
57. Visualizing the solvent-inaccessible core of a group 11 intron ribozyme
58. Efficient integration of an intron RNA into double-stranded DNA by reverse splicing
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60. The final cut. The importance of tRNA 3′-processing
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65. Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA
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77. Exploring the folding landscape of a structured RNA
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82. Guanosine binds to the Tetrahymena ribozyme in more than one step, and its 2′-OH and the nonbridging pro-Sp phosphoryl oxygen at the cleavage site are required for productive docking
83. Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops
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85. Unusual resistance of peptidyl transferase to protein extraction procedures
86. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
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95. The question remains: Is the spliceosome a ribozyme?
96. Metal-ion coordination by U 6 small nuclear RNA contributes to catalysis in the spliceosome
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