Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation

Human Molecular Genetics

Volumn 13, Issue 2, 2004, Pages 235-246

  Davies, Jamie A ^a   Ladomery, Michael ^b,c   Hohenstein, Peter ^b   Michael, Lydia ^a   Shafe, Anna ^b   Spraggon, Lee ^b   Hestie, Nick ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WT1 PROTEIN; WT4 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CHILDHOOD DISEASE; CONTROLLED STUDY; DENYS DRASH SYNDROME; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GLOMERULUS; GROWTH INHIBITION; HYPOTHESIS; KIDNEY CELL CULTURE; KIDNEY DEVELOPMENT; MOUSE; MUTATIONAL ANALYSIS; NEPHROBLASTOMA; NEPHRON; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC TECHNIQUES; KIDNEY; MESODERM; MICE; MICE, MUTANT STRAINS; NEPHRONS; ORGAN CULTURE TECHNIQUES; PAX2 TRANSCRIPTION FACTOR; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; URETER; WNT PROTEINS; WT1 PROTEINS;

ANIMALIA; GLOMERULUS;

EID: 1642514813     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh015     Document Type: Review

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