RNA interference in human cells is restricted to the cytoplasm

RNA

Volumn 8, Issue 7, 2002, Pages 855-860

  Zeng, Yan ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

RNA export; RNA interference; RNA stability; siRNAs

Indexed keywords

MESSENGER RNA; RNA;

ARTICLE; CYTOPLASM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPRODUCIBILITY; RIBONUCLEASE PROTECTION ASSAY; RNA ANALYSIS; RNA DEGRADATION; RNA STABILITY; WESTERN BLOTTING;

ANIMALS; CELL LINE; CELL NUCLEUS; CYTOPLASM; DROSOPHILA; GENE SILENCING; HUMANS; PLASMIDS; RETROVIRIDAE; RNA STABILITY; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; TRANSFECTION;

EUKARYOTA;

EID: 0036074161     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838202020071     Document Type: Article

References (36)

1. Role for bidentate ribonuclease in the initiation step of RNA interference
2. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins
3. dsRNA-mediated gene silencing in cultured drosophila cells: A tissue culture model for the analysis of RNA interference
4. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
5. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
6. Plants combat infection by gene silencing
7. HIV-1 auxiliary proteins: Making connections in a dying cell
8. A look at messenger RNP moving through the nuclear pore
9. A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans
10. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
11. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
12. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
13. A species of small antisense RNA in posttranscriptional gene silencing in plants
14. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
15. A perfect message: RNA surveillance and nonsense-mediated decay
16. A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA
17. Coupled transcription and translation within nuclei of mammalian cells
18. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
19. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
20. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RnaseD
21. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
22. Identification of novel genes coding for small expressed RNAs
23. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
24. An extensive class of small RNAs in caenorhabditis elegans
25. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
26. Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus resistance
27. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
28. Quality control of mRNA function
29. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
30. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
31. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
32. Glimpses of a tiny RNA world
33. RNA interference-2001
34. The rde-1 gene, RNA interference and transposon silencing in C. elegans
35. Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes
36. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals