Too much interference: Injection of double-stranded RNA has nonspecific effects in the zebrafish embryo

Developmental Biology

Volumn 224, Issue 1, 2000, Pages 20-28

  Oates, Andrew C ^a   Bruce, Ashley E E ^a   Ho, Robert K ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

dsRNA; Embryogenesis; Nieuwkoid; no tail; RNAi; Spadetail; tbx16; Zebrafish

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; RNA;

ANIMAL CELL; ARTICLE; CELL DEATH; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOSS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA ANALYSIS; RNA SEQUENCE; ZEBRA FISH;

DANIO RERIO;

EID: 0034254815     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9761     Document Type: Article

References (40)

1. RNA interference can target pre-mRNA: Consequences for gene expression in a Caenorhabditis elegans operon
2. RNA interference: Genetic wand and genetic watchdog
3. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
4. Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos
5. Intraembryonic hematopoietic cell migration during vertebrate development
6. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
7. Neural degeneration mutants in the zebrafish, Danio rerio
8. Molecular identification of spadetail: Regulation of zebrafish trunk and tail mesoderm formation by T-box genes
9. Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
10. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
11. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
12. Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors
13. tbx6, a Brachyur-related gene expressed by ventral mesendodermal precursors in the zebrafish embryo
14. Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin
15. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
16. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
17. A mutation that changes cell movement and cell fate in the zebrafish embryo
18. The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish
19. The nieuwkoid/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula
20. Antisense RNA: Function and fate of duplex RNA in cells of higher eukaryotes
21. Double-stranded RNA injection produces null phenotypes in zebrafish
22. Silencing of developmental genes in Hydra
23. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
24. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
25. Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: Only jak2a is expressed during erythropoiesis
26. Zebrafish stat3 is expressed in restricted tissues during embryo-genesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line
27. Molecular cloning of double-stranded RNA inducible Mx genes from Atlantic salmon (Salmo salar L.)
28. Characterization of the zebrafish tbx16 gene and evolution of the vertebrate T-box family
29. Double-stranded RNA specifically disrupts gene expression during planarian regeneration
30. No tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene
31. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
32. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
33. Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos
34. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis
35. Targeted mRNA degradation by double-stranded RNA in vitro
36. Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA
37. Double-stranded RNA induces specific developmental defects in zebrafish embryos
38. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
39. Specific interference with gene function by double-stranded RNA in early mouse development
40. Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm