Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery

Molecular Therapy

Volumn 2, Issue 1, 2000, Pages 63-70

  Gautam, Ajay ^a   Densmore, Charles L ^a   Xu, Bo ^a   Waldrep, J Clifford ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aerosol; CO2; Gene delivery; Lung; PEI

Indexed keywords

FELIS CATUS; TRIXIS;

CARBON DIOXIDE; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; LUCIFERASE; PEROXIDASE; POLYETHYLENEIMINE;

AEROSOL; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; LUNG; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; PLASMID; TIME; TISSUE DISTRIBUTION; TRANSGENE;

AEROSOLS; ANIMALS; CARBON DIOXIDE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; LUCIFERASES; LUNG; MICE; MICE, INBRED BALB C; PEROXIDASE; PLASMIDS; POLYETHYLENEIMINE; TIME FACTORS; TISSUE DISTRIBUTION; TRANSGENES;

EID: 85047676333     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0087     Document Type: Article

References (27)

1. Templeton, N. S., Lasic, D. D., Frederick, P. M., Strey, H. H., Roberts, D. D., and Pavlakis, G. N. (1997). Improved DNA:liposome complexes for increased systemic delivery and gene expression. Nat. Biotechnol. 15: 647-652.
2. Eastman, S. J., et al. (1997). A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high level gene expression in mouse lung. Hum. Gene Ther. 8: 765-773.
3. Li, S., and Huang, L. (1997). In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gen. Ther. 4: 891-900.
4. Boussif, O., et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethyleneimine. Proc. Natl. Acad. Sci. USA 92: 7297-7301.
5. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1999). Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene therapy. Proc. Natl. Acad. Sci. USA 96: 5177-5181.
6. Ferrari, S., Pettenazzo, A., Garbati, N., Zacchello, F., Behr, J.-P., and Scarpa, M. (1999). Polyethyleneimine shows properties of interest for cystic fibrosis gene therapy. Biochim. Biophys. Acta 1447: 219-225.
7. Goula, D., Benoist, C., Mantero, S., Merlo, G., Levi, G., and Demeneix, B. A. (1998). Polyethyleneimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 5: 1291-1295.
8. Abdallah, B., Hassan, A., Benoist, C., Goula, D., Behr, J.-P., and Demeneix, B. A. (1996). A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethyleneimine. Hum. Gene Ther. 7: 1947-1954.
9. Boletta, A., Benigni, A., Lutz, J., Remuzzi, G., Soria, M. R., and Monaco, L. (1997). Nonviral gene delivery to rat kidney with polyethyleneimine. Hum. Gene Ther. 8: 1243-1251.
10. Coll, J.-L., Chollet, P., Brambilla, E., Desplanques, D., Behr, J.-P., and Favrot, M. (1999). In vivo delivery to tumors of DNA complexed with linear polyethyleneimine. Hum. Gene Ther. 10: 1659-1666.
11. Schwartz, L. A., Johnson, J. L., Black, M., Waldrep, J. C., Cheng, S. H., and Knight, V. (1996). Delivery of DNA-cationic liposome complexes by small particle aerosol. Hum. Gene Ther. 7: 731-741.
12. Densmore, C. L., et al. (2000). Aerosol delivery of robust polyethyleneimine-DNA complexes for gene therapy and genetic immunization. Mol. Ther. 1: 180-188.
13. Densmore, C. L., Giddings, T. H., Waldrep, J. C., Kinsey, B. M., and Knight, V. (1999). Gene transfer by guanidinium-cholesterol:dioleoylphosphatidyl-ethanolamine liposome-DNA complexes in aerosol. J. Gene Med. 1: 251-264.
14. Ernst, N., et al. (1999). Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant. J. Gene Med. 1: 331-340.
15. Liu, Y., Liggit, D., Zhong, W., Guanhuan, T., Gaensler, K., and Debs, R. (1995). Cationic liposome-mediated intravenous gene delivery. J. Biol. Chem. 270: 24864-24870.
16. Koshkina, N. V., Gilbert, B. E., Waldrep, J. C., Seryshev, A., and Knight, V. (1999). Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular injection in mice. Cancer Chemother. Pharmacol. 44: 187-192.
17. 99mtechnetium-labeled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers. Int. J. Pharm. 115: 209-216.
18. Knight, V., Koshkina, N. V., Waldrep, J. C., Giovanella, B. C., and Gilbert, B. E. (1999). Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother. Pharmacol. 44: 177-186.
19. Goldblum, S. E., Wu, K.-M., and Jay, M. (1985). Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J. Appl. Physiol. 59: 1978-1985.
20. Schlenker, E. H. (1985). Ventilation and metabolism of the djungarian hamster (Phodopus sungorus) and the albino mouse. Comp. Biochem. Physiol. 82A: 293-295.
21. 2 exposure effects in conscious, restrained CF-1 mice. Pharmacol. Toxicol. 72: 163-168.
22. Goldring, R. M., Cannon, P. J., Heinemann, H. O., and Fishman, A. P. (1968). Respiratory adjustment to chronic metabolic alkalosis in man. J. Clin. Invest. 47: 188-202.
23. 2-enriched air: Pharmacokinetic studies. Submitted for publication.
24. Goldring, R. M., Heinemann, H. O., and Turing, G. M. (1975). Regulation of alveolar ventilation in respiratory failure. Am. J. Med. Sci. 269: 160-170.
25. Bragonzi, A., et al. (1999). Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs. Gene Ther. 6: 1995-2004.
26. Lee, E. R., et al. (1996). Detailed analysis of structure and formulations of cationic lipids for efficient gene transfer to lung. Hum. Gene Ther. 7: 1701-1717.
27. Meyer, K. B., Thompson, M. M., Levy, M. Y., Barren, L. G., and Szoka, F. C., Jr. (1995). Intratracheal gene delivery to mouse airway: Characterization of plasmid DNA expression and pharmacokinetics. Gene Ther. 2: 450-460.