Functional genetic analysis of mouse chromosome 11

Nature

Volumn 425, Issue 6953, 2003, Pages 81-86

  Kile, Benjamin T ^a   Hentges, Kathryn E ^a   Clark, Amander T ^a   Nakamura, Hisashi ^a   Salinger, Andrew P ^a   Liu, Bin ^a   Box, Nell ^a   Stockton, David W ^a   Johnson, Randy L ^b   Behringer, Richard R ^b   Bradley, Allan ^a,c   Justice, Monica J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; DISEASE CONTROL; HUMAN ENGINEERING; MUTAGENESIS;

GENETIC TOOLS;

GENETIC ENGINEERING;

ETHYLNITROSOUREA; MUTAGENIC AGENT;

CHROMOSOME; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MUTAGENESIS; CHROMOSOME 11; CHROMOSOME INVERSION; CHROMOSOME MUTATION; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; EMBRYO; FEMALE; FERTILITY; GENE FUNCTION; GENE ISOLATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC CONSERVATION; HEART DEVELOPMENT; HEMATOPOIESIS; HUMAN; HUMAN GENOME; LETHALITY; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECESSIVE INHERITANCE;

ANIMALS; CARDIOVASCULAR SYSTEM; CHROMOSOMES, MAMMALIAN; CONSERVED SEQUENCE; ETHYLNITROSOUREA; FEMALE; GASTRULA; GENES, LETHAL; HEMATOPOIESIS; HUMANS; INFERTILITY; MALE; MICE; MUTAGENESIS; MUTAGENS; MUTATION;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0042911521     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01865     Document Type: Article

References (30)

1. Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
2. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
3. Justice, M.J. in Genetics and Transgenics: A practical Approach (eds Jackson, I. & Abbott, C.) 185-215 (Oxford Univ. Press, Oxford, 1999).
4. Zheng, B. et al. Engineering a balancer chromosome in the mouse. Nature Genet. 22, 375-378 (1999).
5. Zheng, B., Mills, A. A. & Bradley, A. A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 27, 2354-2360 (1999).
6. Muller, H. J. Genetic variability, twin hybrids, and constant hybrids, in a case of balanced lethal factors. Genetics 3, 422-499 (1918).
7. Kasarskis, A., Manova, K. & Anderson, K. V. A phenotype-based screen for embryonic lethal mutations in the mouse. Proc. Natl Acad. Sci. USA 95, 7485-7490 (1998)
8. Hentges, K., Thompson, K. & Peterson, A. The flat-top gene is required for the expansion and regionalization of the telencephalic primordium. Development 126, 1600-1609 (1999)
9. Herron B. J. et al. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nature Genet. 30, 185-189 (2002).
10. Kamath, R. S. et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237 (2003).
11. Miklos, G. L. & Rubin, G. M. The role of the genome project in determining gene function: insights from model organisms. Cell 86, 521-529 (1996).
12. Shedlovsky, A., King, T. R. & Dove, W. F. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc. Natl Acad. Sci. USA 85, 180-184 (1988).
13. Rinchik, E. M. & Carpenter, D. A. N-ethyl-N-nitrosourea mutagenesis of a 6- to 11 -cM subregion of the Fah-Hbb interval of mouse chromosome 7: completed testing of 4,557 gametes and deletion mapping and complementation analysis of 31 mutations. Genetics 152, 373-383 (1999).
14. Conway, S. J., Kruzynska-Frejtag, A., Kneer, P. L., Machnicki, M. & Koushik, S. V. What cardiovascular defect does my prenatal mouse mutant have, and why? Genesis 35, 1-21 (2003).
15. Nusslein-Volhard, C., Frohnhofer, H. G. & Lehmann, R. Determination ofanteroposterior polarity in Drosophila. Science 238, 1675-1681 (1987).
16. Barrow, J. R. & Capecchi, M. R. Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoyb-4. Development 122, 3817-3828 (1996).
17. Hitotsumachi, S., Carpenter, D. A. & Russell, W. L. Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc. Natl Acad. Sci. USA 82, 6619-6621 (1985).
18. Shawlot, W. & Behringer, R. R. Requirement for Lim1 in head-organizer function. Nature 374, 425-430 (1995).
19. Probst, F. J. et al. Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene. Science 280, 1444-1447 (1998).
20. Nehls, M., Pfeifer, D., Schorpp, M., Hedrich, H. & Boehm, T. New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372, 103-107 (1994).
21. Nusslein-Volhard, C., Wieschaus, E. & Kluding, H. Mutations affecting the pattern ofthe larval cuticle in Drosophila melanogaster 1. Zygotic loci on the second chromosome. Rouxs Arch. Dev. Biol. 193, 267-282 (1984).
22. Peters, L. L. et al. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell 86, 917-927 (1996).
23. Southgate, C. D., Chishti, A. H., Mitchell, B., Yi, S. J. & Palek, J. Targeted disruption of the murine erthyroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Nature Genet. 14, 227-230 (1996).
24. Jarolim, P. et al. Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood 85, 634-640 (1995).
25. Karet, F. E. et al. Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc. Natl Acad. Sci. USA 95, 6337-6342 (1998).
26. Bruce, L. J. et al Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (band 3, AE1) gene. J. Clin. Invest. 100, 1693-1707 (1997).
27. The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420, 563-573 (2002).
28. Behringer, R. R. (ed.) Mouse knockout and mutation database. BioMedNet (http://research.bmn.com/mkmd) (2003).
29. Kile, B. T., Mason-Garrison, C. & Justice, M. J. Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mamm. Genome 14, 81-85 (2003).
30. Noveroske, J. N. et al. Quaking is essential for blood vessel development. Genesis 32, 218-230 (2002).