An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

Nature Genetics

Volumn 33, Issue 3, 2003, Pages 396-400

  Hemann, Michael T ^a   Fridman, Jordan S ^a   Zilfou, Jack T ^a   Hernando, Eva ^b   Paddison, Patrick J ^a   Cordon Cardo, Carlos ^b   Hannon, Gregory J ^a   Lowe, Scott W ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; PROTEIN P53; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; COLONY FORMATION; CONTROLLED STUDY; DISEASE SEVERITY; DNA CONTENT; EXPRESSION VECTOR; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE P53; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; GENE TRP53; HEMATOPOIETIC STEM CELL; HETEROZYGOSITY LOSS; IMMUNOHISTOCHEMISTRY; IRRADIATION; KAPLAN MEIER METHOD; LYMPH NODE HYPERPLASIA; LYMPHOGENESIS; LYMPHOID HYPERPLASIA; LYMPHOMA; MITOSIS INDEX; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE MYC; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RNA ANALYSIS; RNA INTERFERENCE; RNA PROCESSING; SEQUENCE ANALYSIS; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; GENES, MYC; GENES, P53; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HYPERPLASIA; LYMPH NODES; LYMPHOMA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; RNA INTERFERENCE;

ANIMALIA; DROMAIUS NOVAEHOLLANDIAE; MAMMALIA; MUS MUSCULUS; VECTORS;

EID: 0037370309     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1091     Document Type: Article

References (14)

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