Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening

Molecular Cell

Volumn 12, Issue 3, 2003, Pages 627-637

  Aza Blanc, Pedro ^a   Cooper, Christopher L ^a   Wagner, Klaus ^a   Batalov, Serge ^a   Deveraux, Quinn L ^a   Cooke, Michael P ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR; RNA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WNT PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; DOBI GENE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ANALYSIS; GENOMICS; HUMAN; HUMAN CELL; MAMMAL CELL; MIRSA GENE; MITOCHONDRION; MODULATION; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; SCREENING; SIGNAL TRANSDUCTION; TUMOR CELL;

MAMMALIA;

EID: 0141750434     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00348-4     Document Type: Article

References (64)

1. Ashkenazi A., Dixit V.M. Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 11:1999;255-260.
2. Ashrafi K., Chang F.Y., Watts J.L., Fraser A.G., Kamath R.S., Ahringer J., Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 421:2003;268-272.
3. Aurandt J., Vikis H.G., Gutkind J.S., Ahn N., Guan K.L. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc. Natl. Acad. Sci. USA. 99:2002;12085-12090.
4. Balachandran S., Kim C.N., Yeh W.-C., Mak T.W., Bhalla K., Barber G.N. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 17:1998;6888-6902.
5. Beer-Romero P., Glass S., Rolfe M. Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene. 14:1997;595-602.
6. Ben-Levy R., Hooper S., Wilson R., Paterson H.F., Marshall C.J. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr. Biol. 8:1998;1049-1057.
7. Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I.M., Ricci J.E., Edris W.A., Sutherlin D.P., Green D.R., Salvesen G.S. A unified model for apical caspase activation. Mol. Cell. 11:2003;529-541.
8. Bohula E.A., Salisbury A.J., Sohail M., Playford M.P., Riedemann J., Southern E.M., Macaulay V.M. The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. J. Biol. Chem. 278:2003; 15991-15997.
9. Boutros M., Mlodzik M. Dishevelled. at the crossroads of divergent intracellular signaling pathways Mech. Dev. 83:1999;27-37.
10. Boutros M., Paricio N., Strutt D.I., Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 94:1998;109-118.
11. Bruckner S.R., Estus S. JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons. J. Neurosci. Res. 70:2002;665-670.
12. Bruckner S.R., Tammariello S.P., Kuan C.Y., Flavell R.A., Rakic P., Estus S. JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. J. Neurochem. 78:2001;298-303.
13. Chao T.-H., Hayashi M., Tapping R.I., Kato Y., Lee J.-D. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J. Biol. Chem. 274:1999;36035-36038.
14. Chen X., Thakkar H., Tyan F., Gim S., Robinson H., Lee C., Pandey S.K., Nwokorie C., Onwudiwe N., Srivastava R.K. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene. 20:2001;6073-6083.
15. Clissold P.M., Ponting C.P. JmjC. cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta Trends Biochem. Sci. 26:2001;7-9.
16. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:1997;231-241.
17. Deveraux Q.L., Reed J.C. IAP family proteins - suppressors of apoptosis. Genes Dev. 13:1999;239-252.
18. Dominguez I., Green J.B. Missing links in GSK3 regulation. Dev. Biol. 235:2001;303-313.
19. Driessens M.H., Hu H., Nobes C.D., Self A., Jordens I., Goodman C.S., Hall A. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho. Curr. Biol. 11:2001;339-344.
20. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498. a.
21. Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:2001;188-200. b.
22. Fraser A.G., Kamath R.S., Zipperlen P., Martinez-Campos M., Sohrmann M., Ahringer J. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature. 408:2000;325-330.
23. Fukunaga R., Hunter T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1997;1921-1933.
24. Gale M. Jr., Blakely C.M., Hopkins D.A., Melville M.W., Wambach M., Romano P.R., Katze M.G. Regulation of interferon-induced protein kinase PKR. modulation of P58IPK inhibitory function by a novel protein, P52rIPK Mol. Cell. Biol. 18:1998;859-871.
25. Gale M. Jr., Blakely C.M., Darveau A., Romano P.R., Korth M.J., Katze M.G. P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Biochemistry. 41:2002;11878-11887.
26. Giordano S., Corso S., Conrotto P., Artigiani S., Gilestro G., Barberis D., Tamagnone L., Comoglio P.M. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat. Cell Biol. 4:2002;720-724.
27. Gonczy P., Echeverri C., Oegema K., Coulson A., Jones S.J., Copley R.R., Duperon J., Oegema J., Brehm M., Cassin E.et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature. 408:2000;331-336.
28. Granziero L., Circosta P., Scielzo C., Frisaldi E., Stella S., Geuna M., Giordano S., Ghia P., Caligaris-Cappio F. CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes. Blood. 101:2003;1962-1969.
29. Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature. 406:2000;86-90.
30. Holen T., Amarzguioui M., Wiiger M.T., Babaie E., Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 30:2002;1757-1766.
31. Hoppe-Seyler F., Butz K. Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J. Virol. 67:1993;3111-3117.
32. Ishitani T., Kishida S., Hyodo-Miura J., Ueno N., Yasuda J., Waterman M., Shibuya H., Moon R.T., Ninomiya-Tsuji J., Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol. Cell. Biol. 23:2003;131-139. a.
33. Ishitani T., Ninomiya-Tsuji J., Matsumoto K. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol. Cell. Biol. 23:2003;1379-1389. b.
34. Jackson A.L., Bartz S.R., Schelter J., Kobayashi S.V., Burchard J., Mao M., Li B., Cavet G., Linsley P.S. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21:2003;635-637.
35. Jaffer Z.M., Chernoff J. p21-activated kinases. three more join the Pak Int. J. Biochem. Cell Biol. 34:2002;713-717.
36. Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M.et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature. 421:2003;231-237.
37. Kasler H.G., Victoria J., Duramad O., Winoto A. ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain. Mol. Cell. Biol. 20:2000;8382-8389.
38. Katagiri K., Yokoyama K.K., Yamamoto T., Omura S., Irie S., Katagiri T. Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. J. Biol. Chem. 271:1996;11557-11562.
39. Kennedy S.G., Kandel E.S., Cross T.K., Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19:1999;5800-5810.
40. Kim L., Kimmel A.R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr. Opin. Genet. Dev. 10:2000;508-514.
41. Kim K., Fisher M.J., Xu S.Q., el-Deiry W.S. Molecular determinants of response to TRAIL in killing of normal and cancer cells. Clin. Cancer Res. 6:2000;335-346.
42. Kim K., Takimoto R., Dicker D.T., Chen Y., Gazitt Y., El-Deiry W.S. Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines. Int. J. Oncol. 18:2001;241-247.
43. Lee H.O., Herndon J.M., Barreiro R., Griffith T.S., Ferguson T.A. Trail. a mechanism of tumor surveillance in an immune privileged site J. Immunol. 169:2002;4739-4744.
44. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
45. Lin A. Activation of the JNK signaling pathway. breaking the brake on apoptosis Bioessays. 25:2003;17-24.
46. Lum L., Yao S., Mozer B., Rovescalli A., Von Kessler D., Nirenberg M., Beachy P.A. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science. 299:2003;2039-2045.
47. Moriguchi T., Kawachi K., Kamakura S., Masuyama N., Yamanaka H., Matsumoto K., Kikuchi A., Nishida E. Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates. J. Biol. Chem. 274:1999;30957-30962.
48. Noguchi K., Kitanaka C., Yamana H., Kokubu A., Mochizuki T., Kuchino Y. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J. Biol. Chem. 274:1999;32580-32587.
49. Okamoto S.-i., Krainc D., Sherman K., Lipton S.A. Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc. Natl. Acad. Sci. USA. 97:2000;7561-7566.
50. Schurmann A., Mooney A.F., Sanders L.C., Sells M.A., Wang H.G., Reed J.C., Bokoch G.M. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol. Cell. Biol. 20:2000;453-461.
51. She Q.-B., Ma W.-Y., Zhong S., Dong Z. Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of bad by ultraviolet B radiation. J. Biol. Chem. 277:2002;24039-24048.
52. Smyth M.J., Takeda K., Hayakawa Y., Peschon J.J., van den Brink M.R., Yagita H. Nature's TRAIL - on a path to cancer immunotherapy. Immunity. 18:2003;1-6.
53. Stark G.R., Kerr I.M., Williams B.R.G., Silverman R.H., Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67:1998;227-264.
54. Suzaki Y., Yoshizumi M., Kagami S., Koyama A.H., Taketani Y., Houchi H., Tsuchiya K., Takeda E., Tamaki T. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells. Potential role in cell survival following oxidative insults. J. Biol. Chem. 277:2002;9614-9621.
55. Tamagnone L., Artigiani S., Chen H., He Z., Ming G.I., Song H., Chedotal A., Winberg M.L., Goodman C.S., Poo M.et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 99:1999;71-80.
56. Tassi E., Biesova Z., Di Fiore P.P., Gutkind J.S., Wong W.T. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J. Biol. Chem. 274:1999;33287-33295.
57. Tsuneoka M., Koda Y., Soejima M., Teye K., Kimura H. A novel myc target gene, mina53, that is involved in cell proliferation. J. Biol. Chem. 277:2002;35450-35459.
58. Utz P.J., Hottelet M., Le T.M., Kim S.J., Geiger M.E., van Venrooij W.J., Anderson P. The 72-kDa component of signal recognition particle is cleaved during apoptosis. J. Biol. Chem. 273:1998;35362-35370.
59. Verhagen A.M., Vaux D.L. Cell death regulation by the mammalian IAP antagonist Diablo/Smac. Apoptosis. 7:2002;163-166.
60. Waskiewicz A.J., Johnson J.C., Penn B., Mahalingam M., Kimball S.R., Cooper J.A. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19:1999;1871-1880.
61. Waterhouse N.J., Ricci J.E., Green D.R. And all of a sudden it's over. mitochondrial outer-membrane permeabilization in apoptosis Biochimie. 84:2002;113-121.
62. Yang D.D., Kuan C.Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389:1997;865-870.
63. Zhang Y., Neo S.Y., Han J., Lin S.C. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 275:2000;25008-25014.
64. Zheng W.H., Kar S., Quirion R. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J. Biol. Chem. 275:2000;39152-39158.