Stable suppression of tumorigenicity by virus-mediated RNA interference

Cancer Cell

Volumn 2, Issue 3, 2002, Pages 243-247

  Brummelkamp, Thijn R ^a   Bernards, René ^a   Agami, Reuven ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; RETROVIRUS VECTOR; SMALL INTERFERING RNA; VIRUS RNA;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; GENE THERAPY; HETEROZYGOSITY LOSS; NONHUMAN; ONCOGENE RAS; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR CELL; VIRAL GENE DELIVERY SYSTEM; WILD TYPE; ANIMAL; CELL CULTURE; CELL DIVISION; FLUORESCENT ANTIBODY TECHNIQUE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; MOUSE; NEOPLASM; NORTHERN BLOTTING; NUDE MOUSE; PANCREAS TUMOR; PHYSIOLOGY; RETROVIRUS; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIVISION; FLUORESCENT ANTIBODY TECHNIQUE; GENES, RAS; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; NEOPLASMS; PANCREATIC NEOPLASMS; RETROVIRIDAE; RNA INTERFERENCE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036726313     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00122-8     Document Type: Article

References (21)

1. Agami, R., and Bernards, R. (2000). Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102, 55-66.
2. Barbacid, M. (1987). ras genes. Annu. Rev. Biochem. 56, 779-827.
3. Bos, J.L. (1989). ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689.
4. Brummelkamp, T.R., Bernards, R., and Agami, R. (2002). A System for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553.
5. Campbell, S.L., Khosravi-Far, R., Rossman, K.L., Clark, G.J., and Der, C.J. (1998). Increasing complexity of Ras signaling. Oncogene 17, 1395-1413.
6. Chin, L., Tam, A., Pomerantz, J., Wong, M., Holash, J., Bardeesy, N., Shen, Q., O'Hagan, R., Pantginis, J., Zhou, H., et al. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472.
7. Fisher, G.H., Wellen, S.L., Klimstra, D., Lenczowski, J.M., Tichelaar, J.W., Lizak, M.J., Whitsett, J.A., Koretsky, A., and Varmus, H.E. (2001). Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15, 3249-3262.
8. Gitlin, L., Karelsky, S., and Andino, R. (2002). Short interfering RNA confers intracellular antiviral immunity in human cells. Nature 418, 430-434.
9. Hahn, W.C., and Weinberg, R.A. (2002). Modelling the molecular circuitry of cancer. Nat. Rev. Cancer 2, 331-341.
10. Hanahan, D., and Weinberg, R.A. (2000). The hallmarks of cancer. Cell 100, 57-70.
11. Jackson, E.L., Willis, N., Mercer, K., Bronson, R.T., Crowley, D., Montoya, R., Jacks, T., and Tuveson, D.A. (2001). Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248.
12. Jacque, J.M., Triques, K., and Stevenson, M. (2002). Modulation of HIV-1 replication by RNA interference. Nature 418, 435-438.
13. Johnson, L., Greenbaum, D., Cichowski, K., Mercer, K., Murphy, E., Schmitt, E., Bronson, R.T., Umanoff, H., Edelmann, W., Kucherlapati, R., and Jacks, T. (1997). K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468-2481.
14. Johnson, L., Mercer, K., Greenbaum, D., Bronson, R.T., Crowley, D., Tuveson, D.A., and Jacks, T. (2001). Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111-1116.
15. Lee, R.C., Feinbaum, R.L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854.
16. Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A., and Herweijer, H. (2002). Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. Published online July 29, 2002. 10.1038/ng944
17. McCaffrey, A.P., Meuse, L., Pham, T.T., Conklin, D.S., Hannon, G.J., and Kay, M.A. (2002). RNA interference in adult mice. Nature 418, 38-39.
18. McCormick, F. (1989). ras GTPase activating protein: signal transmitter and signal terminator. Cell 56, 5-8.
19. McCormick, F. (1990). GTP binding and growth control. Curr. Opin. Cell Biol. 2, 181-184.
20. Novina, C.D., Murray, M.F., Dykxhoorn, D.M., Beresford, P.J., Riess, J., Lee, S.K., Collman, R.G., Lieberman, J., Shankar, P., and Sharp, P.A. (2002). siRNA-directed inhibition of HIV-1 infection. Nat. Med. 8, 681-686.
21. Tuschl, T. (2002). Expanding small RNA interference. Nat. Biotechnol. 20, 446-448.