Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery

Science

Volumn 303, Issue 5658, 2004, Pages 669-672

  Pal Bhadra, Manika ^a,c   Leibovitch, Boris A ^b   Gandhi, Sumit G ^c   Rao, Madhusudana ^c   Bhadra, Utpal ^a,c   Birchler, James A ^a   Elgin, Sarah C R ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; RNA;

MUTATION; POSITION EFFECT VARIEGATION (PEV);

BIOTECHNOLOGY;

HETEROCHROMATIN PROTEIN 1; HISTONE H3; LYSINE; METHYLTRANSFERASE; PROTEIN; PROTEIN HP2; RNA; UNCLASSIFIED DRUG;

GENE TRANSFER; RNA;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENE MUTATION; GENE SILENCING; GENETIC CODE; HETEROCHROMATIN; METHYLATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA INTERFERENCE; TRANSGENE;

ADENOSINE TRIPHOSPHATASES; ALLELES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CHROMOSOMAL PROTEINS, NON-HISTONE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE PROTEINS; GENE SILENCING; GENES, INSECT; HETEROCHROMATIN; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; METHYLATION; MUTATION; PROTEINS; RNA INTERFERENCE; TRANSGENES;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER; SOLANUM MELONGENA;

EID: 0942279615     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092653     Document Type: Article

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23. We thank T. Jenuwein for antibodies specific for modified histones, H. Lin for alleles of piwi and aubergine, C. Berg for homeless alleles, D. Dorer and S. Ronsseray for mini-white arrays, and members of our research groups for critical review of the manuscript. N. Pavelka, P. Ghana, and C. Craig provided excellent technical assistance. This work was supported by grants from the NIH (HD23844 and GM68388 to S.C.R.E.), the NSF (MCB 0211376 to J.A.B.), the Human Frontier Science Program and a Wellcome Trust Senior Fellowship (RGY20/2003 and Wt2001 to U.B).