N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah- Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations

Genetics

Volumn 152, Issue 1, 1999, Pages 373-383

  Rinchik, Eugene M ^a   Carpenter, Donald A ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MUTAGENESIS; CHROMOSOME 7; CHROMOSOME DELETION; GAMETE; GENE LOCUS; GENE MAPPING; GENETIC COMPLEMENTATION; HOMOZYGOSITY; MOUSE; NONHUMAN; PEDIGREE; PRIORITY JOURNAL;

ANIMALS; BACTERIAL PROTEINS; CHROMOSOME MAPPING; CROSSES, GENETIC; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; ETHYLNITROSOUREA; GENETIC COMPLEMENTATION TEST; HOMOZYGOTE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MODELS, GENETIC; MUTAGENESIS; MUTAGENS; MUTATION; VARIATION (GENETICS);

ANIMALIA;

EID: 0032924464     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. BARRETT, J. A., 1980 The estimation of the number of mutationally silent loci in saturation-mapping experiments. Genet. Res. 35: 33-44.
2. FAUST, C., A. SCHUMACHER, B. HOLDENER and T. MAGNUSON, 1995 The eed mutation disrupts anterior mesoderm production in mice. Development 121: 273-285.
3. GLUECKSOHN-WAELSCH, S., 1979 Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouse. Cell 16: 225-237.
4. HITOTSUMACHI, S., D. A. CARPENTER and W. L. RUSSELL, 1985 Doserepetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc. Natl. Acad. Sci. USA 82: 6619-6621.
5. HOLDENER-KENNY, B. C., S. K. SHARAN and T. MAGNUSON, 1992 Mouse albino deletions: from genetics to genes in development. Bioessays 14: 831-839.
6. HOLDENER, B. C., C. FAUST, N. S. ROSENTHAL and T. MAGNUSON, 1994 msd is required for mesoderm induction in mice. Development 120: 1335-1346.
7. HOLDENER, B. C., E. M. RINCHIK and T. MAGNUSON, 1995a Phenotypic and physical analysis of a chemically induced mutation disrupting anterior axial development in the mouse. Mamm. Genome 6: 474-475.
8. HOLDENER, B. C., J. W. THOMAS, A. SCHUMACHER, M. D. POTTER, E. M. RINCHIK et al., 1995b Physical localization of eed: A region of mouse chromosome 7 required for gastrulation. Genomics 27: 447-456.
9. KELSEY, G., A. SCHEDL, S. RUPPERT, L. NISWANDER, T. MAGNUSON et al., 1992 Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival. Genomics 14: 275-287.
10. KUSHi, A., K. EDAMURA, M. NOGUCHI, K. AKIYAMA, Y. NISHI et al., 1998 Generation of mutant mice with large chromosomal deletion by use of irradiated ES cells - analysis of large deletion around hprt locus of ES cell. Mamm. Genome 9: 269-273.
11. 611) in the mouse. J. Embryol. Exp. Morphol. 36: 363-371.
12. LEWIS, S. E., H. A. TURCHIN and T. E. WOJTOWICZ, 1978 Fertility studies of complementing genotypes at the albino locus of the mouse. J. Reprod. Fertil. 53: 197-202.
13. NISWANDER, L., D. YEE, E. M. RINCHIK, L. B. RUSSELL and T. MAGNUSON, 1988 The albino-deletion complex and early postimplantation survival in the mouse. Development 102: 45-53.
14. NISWANDER, L., D. YEE, E. M. RINCHIK, L. B. RUSSELL and T. MAGNUSON, 1989 The albino-deletion complex in the mouse defines genes necessary for development of embryonic and extraembryonic ectoderm. Development 105: 175-182.
15. POTTER, M. D., M. L. KLEBIG, D. A. CARPENTER and E. M. RINCHIK, 1995 Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes - Hbb region of mouse chromosome 7. Mamm. Genome 6: 70-75.
16. POTTER, M. D., S. G. SHINPOCK, R. A. POPP, D. M. POPP, V. GODFREY et al., 1997 Mutations in the murine fitness-1 gene result in defective hematopoeisis. Blood 90: 1850-1857.
17. RAMIREZ-SOLIS, R., P. LIU and A. BRADLEY, 1995 Chromosome engineering in mice. Nature 378: 720-724.
18. RIKKE, B. A., D. K. JOHNSON and T. E. JOHNSON, 1997 Murine albino-deletion complex: High-resolution microsatellite map and genetically anchored YAC framework map. Genetics 147: 787-799.
19. RINCHIK, E. M., 1991 Chemical mutagenesis and fine-structure functional analysis of the mouse genome. Trends Genet. 7: 15-21.
20. RINCHIK, E. M., and D. A. CARPENTER, 1993 N-ethyl-N-nitrosourea-induced prenatally lethal mutations define at least two complementation groups within the embryonic ectoderm development (ted) locus in mouse chromosome 7. Mamm. Genome 4: 349-353.
21. RINCHIK, E. M., and L. B. RUSSELL, 1990 Germ-line deletion mutations in the mouse: tools for intensive functional and physical mapping of regions of the mammalian genome, pp. 121-158 in Genome Analysis, Vol. 1, edited by K. DAVIES and S. TILGHMAN. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. RINCHIK, E. M., D. A. CARPENTER and P. B. SELBY, 1990 A strategy for fine-structure functional analysis of a 6- to 11-cM region of mouse chromosome 7 by high-efficiency mutagenesis. Proc. Natl. Acad. Sci. USA 87: 896-900.
23. RINCHIK, E. M., D. A. CARPENTER and C. L. LONG, 1993a Deletion mapping of four N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7. Genetics 135: 1117-1123.
24. RINCHIK, E. M., R. R. TONJES, D. PAUL and M. D. POTTER, 1993b Molecular analysis of radiation-induced albino (c)-locus mutations that cause death at preimplantation stages of development. Genetics 135: 1107-1116.
25. 611 deletion are likely due to dysfunction of a single gene. Proc. Natl. Acad. Sci. USA 92: 6394-6398.
26. RUSSELL, L. B., and G. D. RAYMER, 1979 Analysis of the albino-locus region of the mouse: III. Time of death of prenatal lethals. Genetics 92: 205-213.
27. RUSSELL, L. B., C. S. MONTGOMERY and G. D. RAYMER, 1982 Analysis of the albino-locus region of the mouse. IV. Characterization of 34 deficiencies. Genetics 100: 427-453.
28. RUSSELL, L. B., W. L. RUSSELL, E. M. RINCHIK and P. R. HUNSICKER, 1990 Factors affecting the nature of induced mutations, pp. 271-285 in Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. RUSSELL, W. L., 1951 X-ray-induced mutations in mice. Cold Spring Harbor Symp. Quant. Biol. 16: 327-336.
30. RUSSELL, W. L., E. M. KELLY, P. R. HUNSICKER, J. B. BANGHAM, S. C. MADDUX et al., 1979 Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl. Acad. Sci. USA 76: 5818-5819.
31. SCHMICKEL, R. D., 1986 Contiguous gene syndromes: a component of recognizable syndromes. J. Pediatr. 109: 231-241.
32. SCHUMACHER, A., C. FAUST and T. MAGNUSON, 1996 Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 383: 250-253.
33. THOMAS, J. W., C. LAMANTIA and T. MAGNUSON, 1998 X-ray-induced mutations in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA 95: 1114-1119.
34. YOU, Y., R. BERGSTROM, M. KLEMM, B. LEDERMAN, H. NELSON et al., 1997 Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nat. Genet. 15: 285-288.