Dendritic cells: Immune regulators in health and disease

Physiological Reviews

Volumn 82, Issue 1, 2002, Pages 97-130

  Lipscomb, Mary F ^a   Masten, Barbara J ^a  

^a Dept of Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; VACCINE;

ADOPTIVE IMMUNOTHERAPY; ALLERGIC DISEASE; ALLERGIC ENCEPHALITIS; ALLERGIC REACTION; ANTIGEN PRESENTATION; ASTHMA; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CANCER; CANCER IMMUNOTHERAPY; CELL DIFFERENTIATION; CELL INTERACTION; CELL MATURATION; CELL MIGRATION; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFECTION; LEUKOCYTE ACTIVATION; LEUKOCYTE FUNCTION; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; VACCINE PRODUCTION;

EID: 0036086102     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00023.2001     Document Type: Review

References (397)

1. Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer
2. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
3. Toll-like receptors in the induction of the innate immune response
4. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
5. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
6. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells
7. Opposite effects of IL-10 on the ability of dendritic cells and macrophages to replicate primary CXCR4-dependent HIV-1 strains
8. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessments employing subunit-specific monoclonal antibodies
9. Toll signaling pathways in the innate immune response
10. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
11. MUC1 and breast cancer
12. Thymic dendritic cells
13. CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms
14. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice
15. Antigen-presenting cells. Experimental and clinical studies of dendritic cells
16. Isolation and characterization of dendritic cells from mouse heart and kidney
17. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype
18. Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation
19. Chemokines and leukocyte traffic
20. Immunobiology of dendritic cells
21. Dendritic cells and the control of immunity
22. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp 70, and calreticulin
23. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
24. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity
25. Bacterial cpg-dna triggers activation and maturation of human cd11c(-), cd123(+) dendritic cells
26. Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma
27. CD1 recognition by mouse NK1 + T lymphocytes
28. Cutting edge: Heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo
29. CD91: A receptor for heat shock protein gp 96
30. Human interdigitating dendritic cells directly stimulate CD40-activated naive B cells
31. Interleukin-15 mRNA is expressed by human keratinocytes Langerhans cells, and blood-derived dendritic cells and is down-regulated by ultraviolet B radiation
32. Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells
33. Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4(+) and CD8(+) T cells
34. A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
35. Immunization through dermal delivery of protein-encoding DNA: A role for migratory dendritic cells
36. Selective suppression of IL-12 production by chemoattractants
37. Antigen presentation: A balanced diet
38. The role of dendritic cells in T cell selection and survival
39. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
40. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
41. Identification of a committed T cell precursor population in adult human peripheral blood
42. Genetically engineered dendritic cell-based cancer vaccines (review)
43. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
44. Expression of the chemokine receptor BLIR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2
45. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
46. GM-CSF TNF-alpha cooperate in the generation of dendritic Langerhans cells
47. Respective involvement of TGF-beta and IL-4 in the development of Langerhans cells and non-Langerhans dendritic cells from CD34+ progenitors
48. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha. II. Functional analysis
49. Activation of human dendritic cells through CD40 cross-linking
50. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
51. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
52. Plasmacytoid dendritic cells activated by influenza virus and CD 40L drive a potent TH1 polarization
53. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
54. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
55. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
56. Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin
57. B7-H3: A costimulatory molecule for T cell activation and IFN-gamma production
58. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
59. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments
60. In vivo CD40-CD154 (CD40 ligand) interaction induces untograted HIV expression by APC in an HIV-1-transgenic mouse model
61. The Th1-Th2 hypothesis of HIV infection: New insights
62. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
63. Regulatory activity of autocrine IL-10 on dendritic cell functions
64. Human cytomegalovirus, Mhc class I and inhibitory signalling receptors: More questions than answers
65. A novel immunoglobulin superfamily receptor for cellular and viral Mhc class I molecules
66. ULPBs, novel MHC class I-related molecules, bind to CMV glycoprotein UL 16 and stimulate NK cytotoxicity through the NKG2D receptor
67. T regulatory cells 1 inhibit a Th2-specific response in vivo
68. The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
69. Chemokines and cell migration in secondary lymphoid organs
70. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs
71. The dendritic cell and human cancer vaccines
72. Selective up-regulation of chemokine receptors CCR 4 and CCR8 upon activation of polarized human type 2 Th cells
73. Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: A comparative analysis with Flt 3 ligand
74. Selective transmission of R5-tropic HIV type 1 from dendritic cells to resting CD4+ T cells
75. Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC 3
76. Vasoactive intestinal peptide synergizes with TNF-alpha in inducing human dendritic cell maturation
77. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells
78. Stimulation of dendritic cells via CD 40 enhances immune responses to Mycobacterium tuberculosis infection
79. CD47 engagement inhibits cytokine production and maturation of human dendritic cells
80. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo
81. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
82. Effect of interleukin-10 on dendritic cell maturation and function
83. The evolution of self-tolerance: A new cell arises to meet the challenge of self-reactivity
84. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
85. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors
86. Regulation of dendritic cell trafficking: A process that involves the participation of selective chemokines
87. ICOS co-stimulatory receptor is essential for T-cell activation and function
88. Antigen presentation and DNA vaccines
89. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo
90. Genetic background of attenuated Salmonella typhimurium has profound influence on infection and cytokine patterns in human dendritic cells
91. Toward a role of dendritic cells in the germinal center reaction: Triggering of B cell proliferation and isotype switching
92. Dendritic cells directly modulate B cell growth and differentiation
93. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes
94. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia
95. Tumor's other immune targets: Dendritic cells
96. Tumor necrosis factor-alpha-promoted expression of Bcl-2 and inhibition of mitochondrial cytochrome c release mediate resistance of mature dendritic cells to melanoma-induced apoptosis
97. Plasmacytoid monocytes express IL3-receptor alpha and differentiate into dendritic cells
98. Dendritic cells and prospects for transplantation tolerance
99. Follicular dendritic cell accessory activity crosses MHC and species barriers
100. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
101. Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope
102. Brain dendritic cells and macrophages/microglia in central nervous system inflammation
103. Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major
104. Dendritic cells injected via different routes induce immunity in cancer patients
105. Dendritic cells in cancer immunotherapy
106. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
107. Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site
108. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in noninmmnosuppressed recipients
109. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells
110. Natural adjuvants: Endogenous activators of dendritic cells
111. Danger signals: SOS to the immune system
112. Anti-inflammatory effects of CD95 ligand (FasL)-induced apoptosis
113. Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPBI* 0501 mismatch
114. Identification of DC-SIGN, a novel dendritic cell-specific ICAM- 3 receptor that supports primary immune responses
115. DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking
116. A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon cross-linking by IgA complexes
117. An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow
118. Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells
119. Extolling the diversity of bacterial endotoxins
120. Intraepithelial airway dendritic cells: A distinct subset of pulmonary dendritic cells obtained by microdissection
121. Dendritic cells, but not macrophages, produce IL- 12 immediately following Leishmania donovani infection
122. Direct and indirect recognition: The role of MHC antigens in graft rejection
123. The immunological synapse: A molecular machine controlling T cell activation
124. IL-12 acts selectively on CD8 alpha-dendritic cells to enhance presentation of a tumor peptide in vivo
125. Dendritic cells capable of stimulating T cells in germinal centres
126. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
127. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
128. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells
129. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
130. Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential
131. Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells
132. Dendritic cells acquire antigens from live cells for cross-presentation to CTL
133. Dendritic cells: Unique leukocyte populations which control the primary immune response
134. Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2
135. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model
136. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
137. Kapsenberg ML. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Thl phenotype
138. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
139. Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production
140. Macrophage: Dendritic cell interaction in regulation of IgE response in asthma
141. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways
142. Chemokines in allergy
143. Innate immune system damage in human immunodeficiency virus type 1 infection. Implications for acquired immunity and vaccine design
144. Immunological tolerance to inhaled antigen
145. Autoantigen-pulsed dendritic cells induce tolerance to experimental allergic encephalomyelitis (EAE) in Lewis rats
146. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
147. The duration of antigenic stimulation determines the fate of naive and effector T cells
148. The interplay between the duration of TCR and cytokine signaling determines T cell polarization
149. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
150. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
151. The formation of immunogenic major histocompatibility complex class II: Peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
152. In vivo detection of dendritic cell antigen presentation to CD4(+) T cells
153. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells
154. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine
155. Unique functions of CDllb(+), CD8alpha(+), and double-negative Peyer's patch dendritic cells
156. Modelling T-cell memory by genetic marking of memory T cells in vivo
157. Vaccination for malignant melanoma: Recent developments
158. T cell receptor antagonists and partial agonists
159. Human interdigitating dendritic cells induce isotype switching and IL-13-dependent IgM production in CD40-activated naive B cells
160. Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: A role for IL- 15 in attraction of T cells
161. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion
162. Trance, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
163. Resident and infiltrating central nervous system apcs regulate the emergence and resolution of experimental autoimmune encephalomyelitis
164. Natural interferon alpha/beta-producing cells link innate and adaptive immunity
165. Dendritic-cell function in Toll-like receptor-and MyD88-knockout mice
166. 2, promote type 2 cytokine production in maturing human naive T helper cells
167. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
168. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
169. The development, maturation, and turnover rate of mouse spleen dendritic cell populations
170. Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: Differential regulation by T helper type 1 and T helper type 2 cytokines
171. Ex vivo treatment of antigen-presenting cells with CTLA 4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat
172. The functional relevance of passenger leukocytes and microchrimerism for heart allograft acceptance in the rat
173. Survival, maturation, and function of CD11c- and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines
174. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
175. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
176. Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia
177. Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?
178. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL- 2 production
179. DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses
180. Control of homeostasis of CD8+ memory T cells by opposing cytokines
181. Through the looking glass: The diverse in vivo activities of chemokines
182. Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains: A possible mechanism to polarize Th2 type response in BALB/c mice
183. Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
184. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
185. Kinetics of dendritic cell activation: Impact on priming of TH 1, TH2 and nonpolarized T cells
186. From TCR engagement to T cell activation: A kinetic view of T cell behavior
187. Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
188. From synapses to immunological memory: The role of sustained T cell stimulation
189. Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection
190. Dendritic cells resurrect antigens from dead cells
191. Cytotoxic T-cell memory without antigen
192. Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: Association with reduced nuclear translocation of nuclear factor kappa B
193. Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta
194. Heterogeneity of mouse spleen dendritic cells: In vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover
195. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allo-graft tolerance
196. Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens
197. Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation
198. The dendritic cell-specific cc- chemokine dc-ckl is expressed by germinal center dendritic cells and attracts cd38-negative mantle zone b lymphocytes
199. Vaccination with autologous dendritic cells: From experimental autoimmune enceph-alomyelitis to multiple sclerosis
200. Dendritic cells in experimental allergic encephalomyelitis and multiple sclerosis
201. The regulation of pulmonary immunity
202. A role for TGF-beta in the suppression by murine bronchoalveolar cells of lung dendritic cell initiated immune responses
203. Immune dysregulation as a cause for allergic asthma
204. A potential pathway of Th2 development during primary immune response. IL-10 pretreated dendritic cells can prime naive CD4+ T cells to secrete IL- 4
205. Immune evasion by human cytomegalovirus: Lessons in immunology and cell biology
206. Adenoviral delivery of CTLA 4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients
207. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig)
208. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
209. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD 40L mAb
210. Bone marrowderived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1 dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes
211. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation
212. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor
213. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
214. Role of dendritic cells in the induction and maintenance of autoimmune diseases
215. Mucosa-associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria
216. Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells
217. CD8alpha+ and CD8alpha - Subclasses of dendritic cells direct the development of distinct T helper cells in vivo
218. Role of CD8alpha+ and CD8alpha - Dendritic cells in the induction of primary immune responses in vivo
219. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
220. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
221. In vivo generation of human dendritic cell subsets by Ft 3 ligand
222. Mechanism of measles virus-induced suppression of inflammatory immune responses
223. IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40/CD40 ligand-dependent process
224. Salmonella efficiently enter and survive within cultured CD11c+ dendritic cells initiating cytokine expression
225. Concept of lymphoid versus myeloid dendritic cell lineages revisited: Both CD8alpha(-) and CD8alpha(+) dendritic cells are generated from CD4(low) lymphoid-committed precursors
226. Methods to isolate and study lung dendritic cells
227. Comparison of lung dendritic cells and B cells in stimulating naive antigen-specific T cells
228. Characterization of accessory molecules in murine lung dendritic cell function: Roles for CD80, CD86, CD 54, and CD40L
229. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected "killer" dendritic cells
230. Tolerance, danger, and the extended family
231. ICOS is critical for CD40- mediated antibody class switching
232. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces
233. Innate immunity
234. Biology and biochemistry of the chemokines: A family of chemotactic and inflammatory cytokines
235. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival
236. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: Downregulation by inhaled corticosteroids
237. Interleukin-10
238. Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells
239. Role of dendritic cells in the immune response against allografts
240. An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules
241. Migration of leukocytes across endothelium and beyond: Molecules involved in the transmigration and fate of monocytes
242. New strategies for preventing graft-versus-host disease
243. Mouse dendritic cells express the P2X7 purinergic receptor: Characterization and possible participation in antigen presentation
244. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR 3 in dendritic cells
245. Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
246. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells
247. Dendritic cells in allergy
248. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
249. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
250. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells
251. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
252. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis
253. Mechanisms of MHC class I-restricted antigen processing
254. Flexibility and cooperation among dendritic cells
255. Induction of cytomegalo-virus (CMV)-specific T-cell responses using dendritic cells pulsed with CMV antigen: A novel culture system free of live CMV virions
256. Inhibitory effect of IL-10 on human Langerhans cell antigen presenting function
257. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
258. 3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells
259. A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells
260. Dendritic cells are early cellular targets of Listeria monocytogenes after intestinal delivery and are involved in bacterial spread in the host
261. Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo
262. Modulating the immune response with dendritic cells and their growth factors
263. Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
264. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
265. Apoptosis within spontaneously accepted mouse liver allografts: Evidence for deletion of cytotoxic T cells and implications for tolerance induction
266. Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response
267. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
268. The control of T cell responses by dendritic cell subsets
269. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis
270. The role of dendritic cells in the induction and regulation of immunity to microbial infection
271. Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus
272. Dendritic cells at the end of the millennium
273. Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: A new role for Fas ligand in inflammatory responses
274. Migration of dendritic cells to the draining lymph node after allogeneic or congeneic rat skin transplantation
275. Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus
276. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
277. Chemokines
278. Proliferating dendritic cell progenitors in human blood
279. CTL priming by CD8(+) and CD8(-) dendritic cells in vivo
280. Reactive oxygen species activate human peripheral blood dendritic cells
281. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
282. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
283. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
284. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
285. Selective expression of the eotaxin receptor CCR 3 by human T helper 2 cells
286. The role of chemokine receptors in primary, effector, and memory immune responses
287. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
288. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
289. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production
290. Three populations of mouse lymph node dendritic cells with different origins and dynamics
291. A distinct population of nonphagocytic and low level CD4+ null lymphocytes produce IFN-alpha after stimulation by herpes simplex virus-infected cells
292. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor
293. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
294. Differential stimulation of helper and cytotoxic T cells by dendritic cells after infection by Yersinia enterocolitica in vitro
295. Dendritic cells as adjuvants for immune-mediated resistance to tumors
296. Immunology. It takes more than two to tango
297. Dendritic cells in the lung: What is their relevance to asthma?
298. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
299. Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells
300. DNA vaccination: Antigen presentation and the induction of immunity
301. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
302. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules
303. The inverse association between tuberculin responses and atopic disorder
304. Burnet oration: Dendritic cells: Multiple subtypes, multiple origins, multiple functions
305. Activated T cells induce interleukin-12 production by monocytes via CD40-CD 40 ligand interaction
306. The nature of the principal type 1 interferon-producing cells in human blood
307. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: A prospective cohort study with matched controls
308. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor
309. Th2 cell clonal energy as a consequence of partial activition
310. Oral tolerance
311. A fresh look at tumor immunosurveillance and immunotherapy
312. High-level IL-12 production by human dendritic cells requires two signals
313. Identification of cord blood dendritic cells as an immature CD11c - Population
314. Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties
315. The role of chemokines in the regulation of dendritic cell trafficking
316. Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor
317. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
318. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
319. Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DCI. Evidence for a lymphoid origin of pre-DC2
320. Cell migration, chimerism, and graft acceptance
321. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance
322. Induction of tolerance by IL-10-treated dendritic cells
323. DC-SIGN: A guide to some mysteries of dendritic cells
324. Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen
325. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution
326. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro
327. Antigen presentation and related immunological aspects of HIV-1 vaccines
328. Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro
329. The endocytic activity of dendritic cells
330. Dendritic cells: Immunological sentinels with a central role in health and disease
331. flt3 ligand in cooperation with transforming growth factor-beta1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions
332. Identification of CD68+linperipheral blood cells with dendritic precursor characteristics
333. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
334. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: Dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma
335. Dendritic cell precursors are enriched in the vascular compartment of the lung
336. Separate pathways for antigen presentation by CD1 molecules
337. Intratracheal priming with ovalbuminand ovalbumin 323-339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation
338. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
339. Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis
340. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
341. Granulocyte/macrophage colony-stimulating factor inhibits IL-12 production of mouse Langerhans cells
342. ICOS is essential for effective T-helper-cell responses
343. Dendritic cells in genetic immunization
344. Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness
345. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells
346. Oligosaccharides of hyaluronan are potent activators of dendritic cells
347. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells
348. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10
349. Are dendritic cells the key to liver transplant tolerance?
350. Dendritic cells as regulators of immune reactivity: Implications for transplantation
351. In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Implications for the establishment and maintenance of donor cell chimerism following liver transplantation
352. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
353. Dendritic cell vaccines for cancer immunotherapy
354. 2 is a potent inhibitor of human interleukin 12 production
355. Development of dendritic-cell based prostate cancer vaccine
356. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor
357. Immunotherapeutic strategies for the treatment of plasma cell malignancies
358. Transport of peptide-MHC class II complexes in developing dendritic cells
359. Dual effect of interleukin 4 on HIV-1 expression: Implications for viral phenotypic switch and disease progression
360. T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice
361. Histamine inhibits the production of interleukin-12 through interaction with H2 receptors
362. Cellular interactions involved in Th cell memory
363. Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells
364. Anergic T cells inhibit the antigen-presenting function of dendritic cells
365. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
366. Regulation of toll-like receptors in human monocytes and dendritic cells
367. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
368. CTLA-4 can function as a negative regulator of T cell activation
369. Human CD1d functions as a transplantation antigen and a restriction element in mice
370. Cytokine regulation of human immunodeficiency virus type 1 entry and replication in human monocytes/macrophages through modulation of CCR5 expression
371. OX-40: Life beyond the effector T cell stage
372. HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response
373. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
374. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
375. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
376. Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production
377. The nature of the signals regulating CD8 T cell proliferative responses to CD8alpha+ or CD8alpha- dendritic cells
378. Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells
379. RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
380. Thymic dendritic cell precursors: Relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny
381. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage
382. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response
383. Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow
384. Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: Correlation with receptor expression
385. Adherent dendritic cells expressing high levels of interleukin-10 and low levels of interleukin-12 induce antigen-specific tolerance to experimental autoimmune encephalomyelitis
386. CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of Valpha24JalphaQ T cells: A feedback mechanism for immune regulation
387. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
388. T-cell co-stimulation through B7RP-1 and ICOS
389. Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA- nonidentical unrelated marrow grafts
390. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
391. Transforming growth factor-beta1 polarizes murine hematopoietic progenitor cells to generate Langerhans cell-like dendritic cells through a monocyte/macrophage differentiation pathway
392. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells
393. On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells
394. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
395. Chemokines: A new classification system and their role in immunity
396. Cytokines regulate expression and function of the HIV coreceptor CXCR4 on human mature dendritic cells