Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: Downregulation by inhaled corticosteroids

Clinical and Experimental Allergy

Volumn 26, Issue 5, 1996, Pages 517-524

  Moller G M ^a,c   Overbeek, S E ^a   Van Helden Meeuwsen, C G ^a   Van Haarst, J M W ^a   Prens, E P ^a   Mulder, P G ^a   Postma, D S ^b   Hoogsteden, H C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Antigen presentation; Atopic asthma; Dendritic cells; Inhaled corticosteroids

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; HLA DR ANTIGEN; IPRATROPIUM BROMIDE; T6 ANTIGEN; TERBUTALINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENDRITIC CELL; DOUBLE BLIND PROCEDURE; DOWN REGULATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ASTHMA; BRONCHI; CELL DIVISION; DENDRITIC CELLS; DOUBLE-BLIND METHOD; DOWN-REGULATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUCOUS MEMBRANE; RESPIRATORY FUNCTION TESTS;

EID: 0029927257     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1996.tb00571.x     Document Type: Article

References (40)

1. Corrigan CJ, Kay AB. T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992; 13:12:501-7.
2. Poulter LW, Janossy G, Power C, Sreenan S, Burke C. Immunological/physiological relationships in asthma: potential regulation by lung macrophages. Immunol Today 1994; 15:6:258-61.
3. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 1994; 10:587-93.
4. Davis MM, Bjorkman BJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334:395-402.
5. Inaba K, Steinmann RM. Resting and sensitized T lymphocytes exhibit distinct stimualting (antigen-presenting cell) requirements for growth and lymphokine release. J Exp Med 1984; 160:1717-35.
6. Steinmann RM. The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 1991; 9:271-96.
7. Van Haarst JMW, Wit HJ de, Drexhage HA. Hoogsteden HC. Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung. Am J Respir Cell Mol Biol 1994; 10:487-92.
8. Van Voorhis WC, Hair LS, Steinmann RM, Kaplan G. Human dendritic cells, enrichment and purification from peripheral blood. J Exp Med 1982; 155:1172-87.
9. Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatability complex antigen (1a) .... bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991; 173:1345-56.
10. Melief CJM. Dendritic cells are specialized antigen-presenting cells. Res Immunol 1989; 140:902-6.
11. Murphy G, Bhan A, Sato S, Mihm M, Harrist T. A new immunologie marker for epidermal Langerhans cells. N Engl J Med 1981; 304:791-2.
12. Ishii Y, Takami T, Kokai Y et al. A novel human B cell antigen shared with lymphoid dendritic cells: characterization by a monoclonal antibody. Clin Exp Immunol 1985; 61:624-32.
13. Burke C, Power CK, Norris A et al. Lung function and immunopathological changes after inhaled corticosteroids therapy in asthma. Eur Respir J 1992; 5:73-9.
14. Barnes PJ, Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma. Am Rev Respir Dis 1993; 148:S1-S26.
15. Corrigan CJ, Hackzu A, Gemou-Engesaeth V, Doi S, Kikuchi Y, Takatsu S, Durham SR, Kay AB. CD4-T lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Am Rev Respir Dis 1993; 147:540-7.
16. Borish L, Mascali JJ, Dishuck J et al. Detection of alveolar macrophage-derived IL-1β in asthma. Inhibition with corticosteroids. J Immunol 1992; 149:3078-82.
17. Robinson D, Hamid Q, Sun Ying et al. Prednisolon treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression. Am Rev Respir Dis 1993; 148:401-6.
18. Kerstjens HAM, Brand PLP, Hughes MD et al. and the Dutch CNSLD Study Group. A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. N Engl J Med 1992; 327:1413-9.
19. Brand PLP, Kerstjens HAM, Postma DS et al. and the Dutch CNSLD study group. Long-term multicentre trial in chronic non-specific lung disease: methodology and baseline assessment in adult patients. Eur Respir J 1992; 5:21-31.
20. ATS Task Group. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136:225-31.
21. Cockcroft DW, Kilian DN, Mellon JJA, Hargreave FE. Bronchial hyperreactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977; 7:235-43.
22. Bellini A, Vittori E, Marini M, Ackerman V, Mattoli S. Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma. Chest 1993; 103:997-1005.
23. Fokkens WY. CD-1 (T6), HLA-DR-expressing cells, presumably Langerhans' cells, in nasal mucosu. Allergy 1989; 44:167-72.
24. Holt PG. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur Respir J 1993; 6:120-9.
25. Holt PG, Schon-Hegrad MA, Phillips MJ, McMenamin PG. Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy 1989; 19:597-601.
26. Sertl K, Takemura TT, Tschachler E et al. Dendritic cells with antigen presenting capability reside in airway epithelium, lung parenchyma and visceral pleura. J Exp Med 1986; 163:436-51.
27. Hamid Q, Azzawi M, Sun Ying et al. Expression of mRNA for interleukin-5 in mucosal biopsies from asthma. J Clin Invest 1991; 87:1541-6.
28. Robinson DS, Hamid Q, Sun Ying et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Eng J Med 1992; 326:298-304.
29. + cells of the T-helper 2 subset. J Immunol 1990; 145:2087-91.
30. Hauser C, Snapper J, O'Hara W, Paul W, Katz S. Cultured Langerhans' cells activate type 2 T helper cells which produce 1L-4/BSF1. J Invest Dermatol 1988; 90:A568.
31. Hance AJ. Pulmonary immune cells in health and disease: Dendritic cells and Langerhans' cells. Eur Respir J 1993; 6:1213-20.
32. Caux C, Liu Y, Banchereau J. Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol Today 1995; 16:2-4.
33. Nicod LP, Galve-de Rochemonteix B, Dayer JM. Dissociation between allogeneic T-cell stimulation and interleukin-1 or tumor necrosis factor production by human lung dendritic cells. Am J Respir Cell Mol Biol 1990; 2:515-22.
34. Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, Howarth PH, Holgate ST. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992; 145:669-74.
35. 2-agonist, terbutaline on airway inflammation in newly diagnosed asthma. J Allergy Clin Immunol 1992; 90:32-42.
36. Jeffery PK, Godfrey RW, Ädelroth E, Rogers A, Johansson S-A. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 1992; 145:890-9.
37. Fokkens W. In The pathogenesis of allergic rhinitis, cellular aspects with special emphasis on Langerhans cells. 1991; PhD Thesis, University of Rotterdam.
38. Koyama S, Rennard SI, Leikauf GD, Robbins RA. Bronchial epithelial cells release monocyte chemotactic activity in response to smoke and endotoxin. J Immunol 1991; 147:972-9.
39. Sousa AR, Lane SJ, Nakhostan JA, Yoshimura T, Lee TH, Poston RN. Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol. 1994; 10:142-7.
40. Kradin R, Xia W, Pinto C, Zhao L-H. Substance P - containing unmyelinated C-fibers are present in immediate proximity to airway dendritic cells and may promote their migration during inflammation. Am Rev Respir Dis 1994; 149:A267.