Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1313-1319

  Wykes, Michelle ^a   Pombo, Ana ^a   Jenkins, Chris ^a   MacPherson, G Gordon ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; DENDRITIC CELL; LYMPHOCYTE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CELL COMMUNICATION; DENDRITIC CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; HEMOCYANIN; HORSERADISH PEROXIDASE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; INTERPHASE; MALE; RATS; RATS, INBRED STRAINS; SERUM ALBUMIN; T-LYMPHOCYTES;

EID: 0032145432     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Cella, M., D. Scheidegger, K. Palmer Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
2. Heufler, C., F. Koch, U. Stanzl, G. Topar, M. Wysocka, G. Trinchieri, A. Enk, R. M. Steinman, N. Romani, and G. Schuler. 1996. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as IFN-gamma production by T helper 1 cells. Eur. J. Immunol. 26:659.
3. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741.
4. + T cells. J. Immunol. 154:5071.
5. Caux, C., B. Vanbervliet, C. Massacrier, M. Azuma, K. Okumura, L. L. Lanier, and J. Banchereau. 1994. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180:1841.
6. Inaba, K., M. Witmer Pack, M. Inaba, K. S. Hathcock, H. Sakuta, M. Azuma, H. Yagita, K. Okumura, P. S. Linsley, S. Ikehara, S. Muramatsu, R. J. Hodes, and R. M. Steinman. 1994. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180:1849.
7. Pinchuk, L. M., P. S. Polacino, M. B. Agy, S. J. Klaus, and E. A. Clark. 1994. The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Immunity 1:317.
8. Liu, L. M., and G. G. MacPherson. 1993. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177:1299.
9. Inaba, K., J. Metlay, M. Crowley, and R. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen specific, MHC restricted T cells in situ. J. Exp. Med. 172:631.
10. Inaba, K., R. M. Steinman, and M. D. Witmer. 1984. Clustering of dendritic cells, helper T lymphocytes and histocompatible B cells during primary antibody responses in vitro. J. Exp. Med. 160:858.
11. Inaba, K., A. Granelli-Piperno, and R. M. Steinman. 1983. Dendritic cells induce T lymphocytes to release B cell stimulating factors by an interleukin 2-dependent mechanism. J. Exp. Med. 158:2040.
12. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
13. Roy, M., A. Aruffo, J. Ledbetter, P. Linsley, M. Kehry, and R. Noelle. 1995. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur. J. Immunol. 25:596.
14. Gray, D., P. Dullforce, and S. Jainandunsing. 1994. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction. J. Exp. Med. 180:141.
15. Lederman, S., M. J. Yellin, A. M. Cleary, A. Pernis, G. Inghirami, L. E. Cohn, L. R. Covey, J. J. Lee, P. Rothman, and L. Chess. 1994. T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J. Immunol. 152:2163.
16. Kennedy, M. K., K. M. Mohler, K. D. Shanebeck, P. R. Baum, K. S. Picha, C. A. Otten Evans, C. A. Janeway, Jr., and K. H. Grabstein. 1994. Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur. J. Immunol. 24:116.
17. Eisenstein, E. M., K. Chua, and W. Strober. 1994. B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. J. Immunol. 152:5957.
18. Noelle, R. J., M. Roy, D. M. Shepherd, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA 89:6550.
19. Noelle, R. J., J. Daum, W. C. Bartlett, J. McCann, and D. M. Shepherd. 1991. Cognate interactions between helper T cells and B cells. V. Reconstitution of T helper cell function using purified plasma membranes from activated Th1 and Th2 T helper cells and lymphokines. J. Immunol. 146:1118.
20. Hodgkin, P. D., L. C. Yamashita, R. L. Coffman, and M. R. Kehry. 1990. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J. Immunol. 145:2025.
21. Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. [Published erratum appears in Eur. J. Immunol., 1992, 22:615]. Eur. J. Immunol. 21:2951.
22. Kushnir, N., L. Liu, and G. G. MacPherson. 1998. A novel intraction between dendritic cells and B lymphocytes: role of LFA-1 and stimulation by cross-linking MHC class II. J. Immunol. 160:1774.
23. Kosco, M. H., E. Pflugfelder, and D. Gray. 1992. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J. Immunol. 148:2331.
24. Serban, D., and C. Rordorf Adam. 1987. Binding characteristics of human serum amyloid P component. Scand. J. Immunol. 25:275.
25. van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced co- stimulation of T cells in the development of helper function. Nature 378:620.
26. Pierre, P., S. J. Turley, E. Gatti, M. Hull, J. Meltzer, A. Mirza, K. Inaba, R. M. Steinman, and I. Mellman. 1997. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388:787.
27. Cella, M., A. Engering, V. Pinet, J. Pieters, and A. Lanzavecchia. 1997. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388:782.
28. Diment, S., and P. Stahl. 1985. Macrophage endosomes contain proteases which degrade endocytosed protein ligands. J. Biol. Chem. 260:15311.
29. Lutz, M., P. Rovere, M. Kleijmeer, M. Rescigno, C. Aßmann, V. M., J. Oorschot, H. Geuze, J. Trucy, D. Demandolx, J. Davoust, and P. Ricciardi-Castagnoli. 1997. Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells. J. Immunol. 159:3707.
30. + T cells. J. Exp. Med. 182:2045.
31. Fuleihan, R., N. Ramesh, R. Loh, H. Jabara, R. S. Rosen, T. Chatila, S. M. Fu, I. Stamenkovic, and R. S. Geha. 1993. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl. Acad. Sci. USA 90:2170.
32. Foy, T. M., D. M. Shepherd, F. H. Durie, A. Aruffo, J. A. Ledbetter, and R. J. Noelle. 1993. In vivo CD40-gp39 interactions are essential for thymus- dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 178:1567.
33. De Monte, L., C. P. Thienes, S. Monticelli, M. Busslinger, H. J. Gould, D. Vercelli, J. B. Splawski, S. M. Fu, and P. E. Lipsky. 1997. Regulation of human ε germline transcription: role of B-cell-specific activator protein. Immunoregulatory role of CD40 in human B cell differentiation. Int. Arch. Allergy Immunol. 113:35.
34. Siepmann, K., G. Wohlleben, and D. Gray. 1996. CD40-mediated regulation of interleukin-4 signaling pathways in B lymphocytes. Eur. J. Immunol. 26:1544.
35. Splawski, J. B., J. Nishioka, Y. Nishioka, and P. E. Lipsky. 1996. CD40 ligand is expressed and functional on activated neonatal T cells. J. Immunol. 156:119.
36. Warren, W. D., and M. T. Berton. 1995. Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells: IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J. Immunol. 155:5637.
37. Horner, A. A., H. Jabara, N. Ramesh, and R. S. Geha. 1995. γ/δ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J. Exp. Med. 181:1239.
38. Hodgkin, P. D., B. E. Castle, and M. R. Kehry. 1994. B cell differentiation induced by helper T cell membranes: evidence for sequential isotype switching and a requirement for lymphokines during proliferation. Eur. J. Immunol. 24:239.
39. Splawski, J. B., S. M. Fu, and P. E. Lipsky. 1993. Immunoregulatory role of CD40 in human B cell differentiation. J. Immunol. 150:1276.
40. + human fetal B cells. J. Immunol. 148:3398.
41. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
42. Stavnezer, J. 1996. Immunoglobulin class switching. Curr. Opin. Immunol. 8:199.
43. Pinchuk, L. M., S. J. Klaus, D. M. Magaletti, G. V. Pinchuk, and E. A. Clark. 1996. Functional CD40 ligand expressed by human blood dendritic cells is upregulated by CD40 ligation. J. Immunol. 157:4363.
44. Fayette, J., B. Dubois, S. Vandenabeele, J. M. Bridon, B. Vandervliet, I. Durand, J. Banchereau, C. Caux, and F. Briere. 1997. Human dendritic cells skew isotype switching of CD40-activated naive B cells toward IgA1 and IgA2. J. Exp. Med. 185:1909.
45. De Becker, G., T. Sornasse, N. Nabavi, H. Bazin, F. Tielemans, J. Urbain, O. Leo, and M. Moser. 1994. Immunoglobulin isotype regulation by antigen-presenting cells in vivo. Eur. J. Immunol. 24:1523.
46. Sornasse, T., V. Flamand, G. De Becker, H. Bazin, F. Tielemans, K. Thielemans, J. Urbain, O. Leo, and M. Moser. 1992. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 175:15.
47. Gracie, J. A., and J. Bradley. 1996. Interleukin-12 induces IFN-γ-dependent switching of IgG alloantibody subclass. Eur. J. Immunol. 26:1217.
48. Binder, J., E. Graser, W. W. Hancock, B. Wasowska, M. H. Sayegh, H. D. Volk, and J. W. Kupiec Weglinski. 1995. Downregulation of intragraft IFN-γ expression correlates with increased IgG1 alloantibody response following intrathymic immunomodulation of sensitized rat recipients. Transplantation 60:1516.
49. Cuturi, M. C., R. Josien, D. Cantarovich, L. Bugeon, I. Anegon, S. Menoret, H. Smit, P. Douillard, and J. P. Soulillou. 1994. Decreased anti-donor major histocompatibility complex class I and increased class II alloantibody response in allograft tolerance in adult rats. Eur. J. Immunol. 24:1627.
50. Saoudi, A., J. Kuhn, K. Huygen, Y. de Kozak, T. Velu, M. Goldman, P. Druet, and B. Bellon. 1993. Role of the TH1-TH2 balance in the development of autoimmunity in rats. Transplant. Proc. 25:2824.
51. Sayegh, M. H., E. Akalin, W. W. Hancock, M. E. Russell, C. B. Carpenter, P. S. Linsley, and L. A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869.
52. + T cells to produce IL-4. J. Immunol. 158:4171.
53. Maruo, S., M. Oh-hora, H. J. Ahn, S. Ono, M. Wysocka, Y. Kaneko, H. Yagita, K. Okumura, H. Kikutani, T. Kishimoto, M. Kobayashi, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions. J. Immunol. 158:120.
54. Stockinger, B., T. Zal, A. Zal, and D. Gray. 1996. B cells solicit their own help from T cells. J. Exp. Med. 183:891.