메뉴 건너뛰기




Volumn 68, Issue 6, 1999, Pages 747-757

Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD86 ANTIGEN; GLYCOPROTEIN GP 39; INTERLEUKIN 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 0033610269     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199909270-00006     Document Type: Article
Times cited : (82)

References (58)
  • 1
    • 0032564659 scopus 로고    scopus 로고
    • Antigen localization and migration in immunity and tolerance
    • Starzl TE, Zinkernagel R. Antigen localization and migration in immunity and tolerance. N Engl J Med 1998; 339: 1905.
    • (1998) N Engl J Med , vol.339 , pp. 1905
    • Starzl, T.E.1    Zinkernagel, R.2
  • 3
    • 0027175504 scopus 로고
    • Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance
    • Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
    • (1993) Hepatology , vol.17 , pp. 1127
    • Starzl, T.E.1    Demetris, A.J.2    Trucco, M.3
  • 5
    • 0031670937 scopus 로고    scopus 로고
    • Antigen persistence and time point of T cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection
    • Ehl S, Aichele P, Ramseier H, et al. Antigen persistence and time point of T cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection. Nature Med 1998; 4: 1015.
    • (1998) Nature Med , vol.4 , pp. 1015
    • Ehl, S.1    Aichele, P.2    Ramseier, H.3
  • 6
    • 0027768858 scopus 로고
    • Hematolymphoid cell trafficking, microchimerism, and GVHD reactions after liver, bone marrow, and heart transplantation
    • Demetris AJ, Murase N, Fujisaki S, Fung JJ, Rao AS, Starzl TE. Hematolymphoid cell trafficking, microchimerism, and GVHD reactions after liver, bone marrow, and heart transplantation. Transplant Proc 1993; 25: 3337.
    • (1993) Transplant Proc , vol.25 , pp. 3337
    • Demetris, A.J.1    Murase, N.2    Fujisaki, S.3    Fung, J.J.4    Rao, A.S.5    Starzl, T.E.6
  • 8
    • 0029150092 scopus 로고
    • Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor
    • Lu L, Rudert WA, Qian S, et al. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J Exp Med 1995; 182: 379.
    • (1995) J Exp Med , vol.182 , pp. 379
    • Lu, L.1    Rudert, W.A.2    Qian, S.3
  • 10
    • 0029153145 scopus 로고
    • Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown-Norway rats
    • Murase N, Starzl TE, Tanabe M, et al. Variable chimerism, graft versus host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown-Norway rats. Transplantation 1995; 60: 158.
    • (1995) Transplantation , vol.60 , pp. 158
    • Murase, N.1    Starzl, T.E.2    Tanabe, M.3
  • 11
    • 0029934768 scopus 로고    scopus 로고
    • Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues
    • Bishop GA, Sun J, DeCruz DJ, et al. Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J Immunol 1996; 156: 4925.
    • (1996) J Immunol , vol.156 , pp. 4925
    • Bishop, G.A.1    Sun, J.2    DeCruz, D.J.3
  • 12
    • 0030776194 scopus 로고    scopus 로고
    • High-dose/ activation-associated tolerance. A mechanism for allograft tolerance
    • Bishop GA, Sun JN, Sheil AGR, McCaughan GW. High-dose/ activation-associated tolerance. A mechanism for allograft tolerance. Transplantation 1997; 64: 1377.
    • (1997) Transplantation , vol.64 , pp. 1377
    • Bishop, G.A.1    Sun, J.N.2    Sheil, A.G.R.3    McCaughan, G.W.4
  • 13
    • 0031570116 scopus 로고    scopus 로고
    • Apoptosis within spontaneously accepted mouse liver allografts
    • Qian S, Lu L, Fu F, et al. Apoptosis within spontaneously accepted mouse liver allografts. J Immunol 1997; 158: 4654.
    • (1997) J Immunol , vol.158 , pp. 4654
    • Qian, S.1    Lu, L.2    Fu, F.3
  • 14
    • 0032535197 scopus 로고    scopus 로고
    • Apoptosis of T lymphocytes in liver and/or small bowel allografts during tolerance induction
    • Meyer D, Baumgardt S, Loeffeler S, et al. Apoptosis of T lymphocytes in liver and/or small bowel allografts during tolerance induction. Transplantation 1998; 66: 1530.
    • (1998) Transplantation , vol.66 , pp. 1530
    • Meyer, D.1    Baumgardt, S.2    Loeffeler, S.3
  • 16
    • 0344906174 scopus 로고    scopus 로고
    • Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
    • Lu L, Li W, Fu F, et al. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 1997; 64: 1808.
    • (1997) Transplantation , vol.64 , pp. 1808
    • Lu, L.1    Li, W.2    Fu, F.3
  • 17
    • 0029586520 scopus 로고
    • GM-CSF stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival
    • Rastellini C, Lu L, Ricordi C, Starzl TE, Rao AS, Thomson AW. GM-CSF stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 1995; 60: 1366.
    • (1995) Transplantation , vol.60 , pp. 1366
    • Rastellini, C.1    Lu, L.2    Ricordi, C.3    Starzl, T.E.4    Rao, A.S.5    Thomson, A.W.6
  • 18
    • 0029835032 scopus 로고    scopus 로고
    • -) prolong cardiac allograft survival in non-immunosuppressed recipients
    • -) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplantation 1996; 62: 659.
    • (1996) Transplantation , vol.62 , pp. 659
    • Fu, F.1    Li, Y.2    Qian, S.3
  • 19
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693.
    • (1992) J Exp Med , vol.176 , pp. 1693
    • Inaba, K.1    Inaba, M.2    Romani, N.3
  • 20
    • 0028236866 scopus 로고
    • Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of type-1 collagen
    • Lu L, Woo J, Rao AS, et al. Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of type-1 collagen. J Exp Med 1994; 179: 1823.
    • (1994) J Exp Med , vol.179 , pp. 1823
    • Lu, L.1    Woo, J.2    Rao, A.S.3
  • 21
    • 0031570408 scopus 로고    scopus 로고
    • Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation
    • Lu L, Qian S, Hershberger P, Rudert WA, Lynch DH and Thomson AW. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 1997; 158: 5676.
    • (1997) J Immunol , vol.158 , pp. 5676
    • Lu, L.1    Qian, S.2    Hershberger, P.3    Rudert, W.A.4    Lynch, D.H.5    Thomson, A.W.6
  • 22
    • 0028928723 scopus 로고
    • In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients
    • Thomson AW, Lu L, Subbotin VM, et al. In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Transplantation 1995; 59: 544.
    • (1995) Transplantation , vol.59 , pp. 544
    • Thomson, A.W.1    Lu, L.2    Subbotin, V.M.3
  • 25
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng X-G, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 1996; 93: 13967.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13967
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.-G.3    Peach, R.4    Linsley, P.S.5    Turka, L.A.6
  • 26
    • 0032533476 scopus 로고    scopus 로고
    • The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo
    • Niimi M, Pearson TC, Larsen CP, et al. The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo. J Immunol 1998; 161: 5331.
    • (1998) J Immunol , vol.161 , pp. 5331
    • Niimi, M.1    Pearson, T.C.2    Larsen, C.P.3
  • 27
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection: Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection: suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61: 4.
    • (1996) Transplantation , vol.61 , pp. 4
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 28
    • 0030028901 scopus 로고    scopus 로고
    • Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation: With particular reference to the liver
    • Murase N, Starzl TE, Ye Q, et al. Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation: with particular reference to the liver. Transplantation 1996; 61: 1.
    • (1996) Transplantation , vol.61 , pp. 1
    • Murase, N.1    Starzl, T.E.2    Ye, Q.3
  • 31
    • 0030975532 scopus 로고    scopus 로고
    • Antigen localization regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
    • Zinkernagel RM, Ehl S, Aichele P, Oehen S, Kundig T, Hengartner H. Antigen localization regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev 1997; 156: 199.
    • (1997) Immunol Rev , vol.156 , pp. 199
    • Zinkernagel, R.M.1    Ehl, S.2    Aichele, P.3    Oehen, S.4    Kundig, T.5    Hengartner, H.6
  • 32
    • 0025755292 scopus 로고
    • Ablation of "tolerance" and induction of diabetes by viruses infection in viral antigen transgenic mice
    • Ohashi PS, Oehen S, Buerki K, et al. Ablation of "tolerance" and induction of diabetes by viruses infection in viral antigen transgenic mice. Cell 1991; 65: 305.
    • (1991) Cell , vol.65 , pp. 305
    • Ohashi, P.S.1    Oehen, S.2    Buerki, K.3
  • 33
    • 0027232799 scopus 로고
    • Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-α
    • Ohashi PS, Oehen S, Aichele P, et al. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-α. J Immunol 1993; 150: 5185.
    • (1993) J Immunol , vol.150 , pp. 5185
    • Ohashi, P.S.1    Oehen, S.2    Aichele, P.3
  • 34
    • 0005032084 scopus 로고
    • The antigen persistence concept of homograft tolerance: Immunologic response to tumor and spleen cells following transfer, reimplantation and parabiosis
    • Aust JB, Rogers W, Guttmann R. The antigen persistence concept of homograft tolerance: immunologic response to tumor and spleen cells following transfer, reimplantation and parabiosis. Ann Surg 1965; 162: 738.
    • (1965) Ann Surg , vol.162 , pp. 738
    • Aust, J.B.1    Rogers, W.2    Guttmann, R.3
  • 35
    • 0023228892 scopus 로고
    • Alloantigen persistence in induction and maintenance of transplantation tolerance
    • Morecki S, Leshem B, Eid A, Slavin S. Alloantigen persistence in induction and maintenance of transplantation tolerance. J Exp Med 1987; 165: 1468.
    • (1987) J Exp Med , vol.165 , pp. 1468
    • Morecki, S.1    Leshem, B.2    Eid, A.3    Slavin, S.4
  • 36
    • 0023390431 scopus 로고
    • Molecular events in the induction of a nonresponsive state of interleukin-2 producing helper T lymphocyte clones
    • Jenkins MR, Pardoll DM, Mizuguchi J, Chused TM, Schwartz RH. Molecular events in the induction of a nonresponsive state of interleukin-2 producing helper T lymphocyte clones. Proc Natl Acad Sci USA 1987; 84: 5409.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5409
    • Jenkins, M.R.1    Pardoll, D.M.2    Mizuguchi, J.3    Chused, T.M.4    Schwartz, R.H.5
  • 37
    • 0028001828 scopus 로고
    • The wisdom of hindsight
    • Cohn M. The wisdom of hindsight. Annu Rev Immunol 1994; 12: 1.
    • (1994) Annu Rev Immunol , vol.12 , pp. 1
    • Cohn, M.1
  • 38
    • 0028178873 scopus 로고
    • Signals and signs for lymphocyte responses
    • Janeway CA Jr, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994; 76: 275.
    • (1994) Cell , vol.76 , pp. 275
    • Janeway C.A., Jr.1    Bottomly, K.2
  • 39
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12: 991.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991
    • Matzinger, P.1
  • 40
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184: 1.
    • (1996) J Exp Med , vol.184 , pp. 1
    • Schwartz, R.H.1
  • 43
    • 0026642637 scopus 로고
    • Physiological and molecular mechanisms of lymphocyte homing
    • Picker LJ, Butcher EC. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 1993; 10: 561.
    • (1993) Annu Rev Immunol , vol.10 , pp. 561
    • Picker, L.J.1    Butcher, E.C.2
  • 44
    • 0027392134 scopus 로고
    • Graft versus host disease (GVHD) after BN to LEW compared to LEW to BN rat intestinal transplantation under FK 506
    • Murase N, Demetris AJ, Woo J, et al. Graft versus host disease (GVHD) after BN to LEW compared to LEW to BN rat intestinal transplantation under FK 506. Transplantation 1993; 55: 1.
    • (1993) Transplantation , vol.55 , pp. 1
    • Murase, N.1    Demetris, A.J.2    Woo, J.3
  • 45
    • 0032526283 scopus 로고    scopus 로고
    • Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
    • Wekerle T, Sayegh MH, Hill J, et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 1998; 187: 2037.
    • (1998) J Exp Med , vol.187 , pp. 2037
    • Wekerle, T.1    Sayegh, M.H.2    Hill, J.3
  • 46
    • 0030823184 scopus 로고    scopus 로고
    • Replicative senescence of T cells: Does the hayflick limit lead to immune exhaustion?
    • Effros RB, Pawelec G. Replicative senescence of T cells: does the Hayflick limit lead to immune exhaustion? Immunol Today 1997; 18: 450.
    • (1997) Immunol Today , vol.18 , pp. 450
    • Effros, R.B.1    Pawelec, G.2
  • 47
    • 0032529195 scopus 로고    scopus 로고
    • Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2 deficient mice
    • Dai Z, Konieczny BT, Baddourn PK, Lakkis FG. Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2 deficient mice. J Immunol 1998; 161: 1659.
    • (1998) J Immunol , vol.161 , pp. 1659
    • Dai, Z.1    Konieczny, B.T.2    Baddourn, P.K.3    Lakkis, F.G.4
  • 48
    • 0032031409 scopus 로고    scopus 로고
    • IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
    • Konieczny BT, Dai Z, Elwood ET, et al. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998; 160: 2059.
    • (1998) J Immunol , vol.160 , pp. 2059
    • Konieczny, B.T.1    Dai, Z.2    Elwood, E.T.3
  • 49
    • 0028903939 scopus 로고
    • CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
    • Sayegh MH, Akalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
    • (1995) J Exp Med , vol.181 , pp. 1869
    • Sayegh, M.H.1    Akalin, E.2    Hancock, W.W.3
  • 50
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α-chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor α-chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521.
    • (1995) Immunity , vol.3 , pp. 521
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 51
    • 0029118133 scopus 로고
    • Normal clonal expansion but impaired Fas-mediated cell death and anergy in IL-2-deficient mice
    • Kneitz B, Herman T, Yonehara S, Schimpl A. Normal clonal expansion but impaired Fas-mediated cell death and anergy in IL-2-deficient mice. Eur J Immunol 1995; 25: 2572.
    • (1995) Eur J Immunol , vol.25 , pp. 2572
    • Kneitz, B.1    Herman, T.2    Yonehara, S.3    Schimpl, A.4
  • 52
    • 0031569514 scopus 로고    scopus 로고
    • Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor
    • Van Parijs L, Biuckians A, Ibragimove A, Alt FW, Willerford D, Abbas AK. Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J Immunol 1997; 158: 3738.
    • (1997) J Immunol , vol.158 , pp. 3738
    • Van Parijs, L.1    Biuckians, A.2    Ibragimove, A.3    Alt, F.W.4    Willerford, D.5    Abbas, A.K.6
  • 53
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Rafaeli Y, Parijs LV, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998; 8: 615.
    • (1998) Immunity , vol.8 , pp. 615
    • Rafaeli, Y.1    Parijs, L.V.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 55
    • 0028882526 scopus 로고
    • Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
    • Parker DC, Greiner DL, Phillips NE, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci USA 1995; 92: 9560.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9560
    • Parker, D.C.1    Greiner, D.L.2    Phillips, N.E.3
  • 56
    • 0029031817 scopus 로고
    • In the absence of a CD40 signal, B cells are tolerogenic
    • Buhlmann JE, Foy TM, Aruffo A, et al. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 1995; 2: 645.
    • (1995) Immunity , vol.2 , pp. 645
    • Buhlmann, J.E.1    Foy, T.M.2    Aruffo, A.3
  • 57
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
    • (1996) Nature , vol.381 , pp. 434
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 58
    • 0030024279 scopus 로고    scopus 로고
    • Immunology taught by viruses
    • Zinkernagel RM. Immunology taught by viruses. Science 1996; 271: 173.
    • (1996) Science , vol.271 , pp. 173
    • Zinkernagel, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.