Toward a role of dendritic cells in the germinal center reaction: Triggering of B cell proliferation and isotype switching

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3428-3436

  Dubois, Bertrand ^a   Barthélémy, Clarisse ^a   Durand, Isabelle ^a   Liu, Yong Jun ^a   Caux, Christophe ^a   Brière, Francine ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GERMINAL CENTER; HUMAN; HUMAN CELL; IN VIVO STUDY; LANGERHANS CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CHILD; DENDRITIC CELLS; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; INTERLEUKIN-2; INTERPHASE; L CELLS (CELL LINE); LYMPHOCYTE ACTIVATION; MICE; PLASMA CELLS; SOLUBILITY; TONSIL;

EID: 0344258320     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
2. Liu, Y.-J., J. Zhang, P. J. L. Lane, E. Y.-T. Chan, and I. C. M. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.
3. Liu, Y. J., D. E. Joshua, G. T. Williams, C. A. Smith, J. Gordon, and I. C. M. MacLennan. 1989. Mechanisms of antigen-driven selection in germinal centers. Nature 342:929.
4. Kuppers, R., M. Zhao, M. L. Hansmann, and K. Rajewsky. 1993. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:4955.
5. Kraal, G., I. L. Weissman, and E. C. Butcher. 1982. Germinal centre B cells: antigen specificity and charges in heavy chain class expression. Nature 298:377.
6. Feuillard, J., D. Taylor, M. Casamayor-Palleja, G. D. Johnson, and I. C. M. MacLennan. 1995. Isolation and characteristics of tonsil centroblasts with reference to Ig class switching. Int. Immunol. 7:121.
7. Liu, Y. J., F. Malisan, O. de Bouteiller, C. Guret, S. Lebecque, J. Banchereau, F. C. Mills, E. E. Max, and H. Martinez-Valdez. 1996. Within germinal centers isotype switching of immunoglobulin genes occurs after onset of somatic mutation. Immunity 4:241.
8. Kosco, M. H., and D. Gray. 1992. Signals involved in germinal center reactions. Immunol. Rev. 126:63.
9. Tew, J. G., R.-M. DiLosa, G. F. Burton, M. H. Kosco, L. I. Kupp, A. Masuda, and A. K. Szakal. 1992. Germinal centers and antibody production in bone marrow Immunol. Rev. 126:99.
10. Petrasch, S. G., M. H. Kosco, C. J. Perez-Alvarez, J. Schmitz, and G. Brittinger. 1991. Proliferation of germinal center B lymphocytes in vitro by direct membrane contact with follicular dendritic cells. Immunobiology 183:451.
11. Clark, E. A., K. H. Grabstein, and G. L. Shu. 1992. Cultured human follicular dendritic cells: growth characteristics and interactions with B lymphocytes. J. Immunol. 148:3327.
12. Grouard, G., O. de Bouteiller, J. Banchereau, and Y. J. Liu. 1995. Human follicular dendritic cells enhance cytokine dependent growth and differentiation of CD40 activated B cells. J. Immunol. 155:3345.
13. Tew, J. G., J. Wu, D. Qin, S. Helm, G. F. Burton, and A. K. Szakal. 1997. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156:39.
14. + memory T cells contains preformed CD40 ligand that is rapidly hut transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
15. Grouard, G., I. Durand, L. Filgueira, J. Banchereau, and Y. J. Liu. 1996. Dendritic cells capable of stimulating T cells in germinal centers. Nature 384:364.
16. Dubois, B., B. Vanbervliet, J. Fayette, C. Massacrier, C. van Kooten, F. Brière, J. Banchereau, and C. Caux. 1997. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med. 185:941.
17. Fayette, J., B. Dubois, S. Vandenabeele, J. M. Bridon, B. Vanbervliet, I. Durand, J. Banchereau, C. Caux, and F. Brière. 1997. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J. Exp. Med. 185:1909.
18. Dubois, B., C. Massacrier, B. Vanbervliet, J. Fayette, F. Brière, J. Banchereau, and C. Caux. 1998. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J. Immunol. 6:2223.
19. Garrone, P., E. M. Neidhardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265.
20. Peltz, G. A., M. L. Trounstine, and K. W. Moore. 1988. Cloned and expressed human Fc receptor for IgG mediates ami-CD3 dependent lymphoproliferation. J. Immunol. 141:1891.
21. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. J. Exp. Med. 184:695.
22. Caux, C., C. Dezutter-Dambuyant, D. Schmilt, and J. Banchereau. 1992. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360:258.
23. Ray, A., D. Schmitt, C. Dezutter-Dambuyant, M. C. Fargier, and J. Thivolet. 1989. Reappearance of CD1a antigenic sites after endocytosis on human Langerhans cells evidenced by immunogold labeling. J. Invest. Dermatol. 92:217.
24. Caux, C., C. Dezutter-Dambuyant, Y. J. Liu, and J. Banchereau. 1998. Isolation and propagation of human dendritic cells. In Methods in Microbiology: Immunological Methods. Vol. 25. D. Kabelitz and K. Ziegler, eds. Academic Press, New York p. 505.
25. Defrance, T., B. Vanbervliet, F. Brière, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
26. Defrance, T., B. Vanbervliet, J. Pène, and J. Banchereau. 1988. Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J. Immunol. 141:2000.
27. Brière, F., J. M. Bridon, D. Chevet, G. Souillet, F. Bienvenue, and J. Banchereau. 1994. Interleukin 10 induces B lymphocytes from IgA deficient patients to secrete IgA. J. Clin. Invest. 94:97.
28. Merville, P., J. Dechanet, A. Desmoulière, I. Durand, O. de Bouteiller, P. Garrone, J. Banchereau, and Y. J. Liu. 1996. Bcl-2 positive lonsillar plasma cells are rescued from prompt apoptosis by bone marrow fibroblasts. J. Exp. Med. 183:227.
29. Liu, Y. J., C. Barthélémy, O. de Bouteiller, C. Arpin, I. Durand, and J. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7.1 and B7.2. Immunity 2:238.
30. Arpin, C., J. Déchanet, C. van Kooten, P. Merville, G. Grouard, F. Brière, J. Banchereau, and Y. J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
31. + B cells to secrete IgG1 and IgG3. J. Exp. Med. 179:757.
32. Malisan, F., F. Brière, J. M. Bridon, N. Harindranath, F. C. Mills, E. E. Max, J. Banchereau, and H. Martinez-Valdez. 1996. IL-10 induces IgG isotype switch recombination in human CD40-activated naive B lymphocytes. J. Exp. Med. 183: 937.
33. De Saint-Vis, B., I. Fugier-Vivier, C. Massacrier, B. Vanbervliet, S. Aït-Yahia, J. Banchereau, Y. J. Liu, S. Lebecque, and C. Caux. 1998. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. 160:1666.
34. Burdin, N., K. van Kooten, L. Galibert, J. S. Abrams, J. Wijdenes, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
35. Liu, Y. J., and C. Arpin. 1997. Germinal center development. Immunol. Rev. 156:111.
36. Butch, A. W., G.-H. Chung, J. W. Hoffmann, and M. H. Nahm. 1993. Cytokine expression by germinal center cells. J. Immunol. 150:39.
37. Toellner, K.-M., D. Scheel-Toellner, R. Sprenger, M. Duchrow, L. H. Trümper, M. Ernst, H.-D. Flad, and J. Gerdes. 1995. The human germinal centre cells, follicular dendritic cells and germinal centre T cells produce B cell-stimulating cytokines. Cytokine 7:344.
38. Holder, M. J., Y.-J. Liu, T. Defrance, L. Flores-Romo, I. C. M. MacLennan, and J. Gordon. 1991. Growth factor requirements for the stimulation of germinal center B cells: evidence for an interleukin 2-dependent pathway of development. Int. Immunol. 3:1243.
39. -ve buoyant) fraction of human tonsil. Int. Immunol. 5:1059.
40. Han, S., K. Hathcock, B. Kheng, T. B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers: roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155:556.
41. Garside, P., E. Ingulli, R. R. Merica, J. G. Johnson, R. J. Noelle, and M. K. Jenkins. 1998. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281:96.
42. Grammer, A. C., M. C. Bergman, Y. Miura, K. Fujita, L. S. Davis, and P. E. Lipsky. 1995. The CD40 ligand expressed by human B cells costimulates B cell responses. J. Immunol. 154:4996.
43. Wykes, M., J. Poudrier, R. Lindstedt, and D. Gray. 1998. Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells. Eur. J. Immunol. 28:548.
44. Pinchuk, L. M., S. J. Klaus, D. M. Magaletti, G. V. Pinchuk, J. P. Norsen, and E. A. Clark. 1996. Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J. Immunol. 157:4363.
45. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, C. van Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263.
46. + blood dendritic cells. Blood 86:3295.
47. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
48. Anderson, D. M., E. Maraskovsky, W. L. Billingsley, W. C. Dougall, M. E. Tometsko, E. R. Roux, M. C. Teepe, R. F. DuBose, D. Cosman, and L. Galibert. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175.
49. Wong, B. R., R. Josien, S. Y. Lee, B. Sauter, H. L. Li, R. M. Steinman, and Y. Choi. 1997. TRANCE (tumor necrosis factor (TNF)-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186:2075.
50. Kosco, M. H., G. F. Burton, Z. F. Kapasi, A. K. Szakal, and J. G. Tew. 1989. Antibody-forming cell induction during an early phase of germinal centre development and its delay with ageing. Immunology 68:312.
51. Holder, M. J., H. Wang, A. E. Milner, M. Casamayor, R. Armitage, M. K. Spriggs, W. C. Fanslow, I. C. M. MacLennan, C. D. Gregory, and J. Gordon. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 23:2368.
52. Gerloni, M., D. Lo, and M. Zanetti. 1998. DNA immunization in relB-deficient mice discloses a role for dendritic cells in IgM→MgG1 switch in vivo. Eur. J. Immunol. 28:516.
53. Rousset, F., E. Garcia, T. Defrance, C. Péronne, N. Vezzio, D. H. Hsu, R. Kastelein, K. W. Moore, and J. Banchereau. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 89:1890.
54. Defrance, T., P. Carayon, G. Billian, J.-C. Guillemot, A. Minty, D. Caput, and P. Ferrara. 1994. Interleukin 13 is a B cell stimulating factor. J. Exp. Med. 179: 135.
55. Pound, J. D., and J. Gordon. 1997. Maintenance of human germinal center B cells in vitro. Blood 89:919.
56. Bette, M., S. C. Jin, T. Germann, M. K. H. Schäfer, E. Weihe, E. Rüde, and B. Fleischer. 1994. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 24:2435.
57. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. In Dendritic Cells in Fundamental and Clinical Immunology. P. Ricciardi-Castagnoli. ed. Plenum Press, New York, p. 21.
58. + hematopoietic progenitor cells. Blood 87:1292.
59. Ardavin, C., L. Wu, C. L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761.
60. Galy, A., M. Travis, D. Cen, and B. Chen. 1995. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3:459.
61. Agger, R., M. Witmer-Pack, N. Romani, H. Stossel, W. J. Swiggard, J. P. Metlay, E. Storozynsky, P. Freimuth, and R. M. Steinman. 1992. Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes. J. Leukocyte Biol. 52:34.
62. Salomon, B., J. L. Cohen, C. Masurier, and D. Klatzmann. 1998. Three populations of mouse lymph node dendritic cells with different origins and dynamics J. Immunol. 160:708.
63. Kelsall, B. L., and W. Strober. 1996. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J. Exp. Med. 183:237.
64. Grouard, G., M. C. Rissoan, L. Filgueira, I. Durand, J. Banchereau, and Y. J. Liu, 1997. The enigmatic plasmacytoid T cells develop into dendritic cells with IL-3 and CD40-ligand. J. Exp. Med. 185:1101.
65. O'Doherty, U., M. Peng, S. Gezelter, W. J. Swiggard, M. Betjes, N. Bhardwaj, and R. M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82:487.
66. Martinez-Pomares, L., M. Kosco-Vilbois, E. Darley, P. Tree, S. Herren, J. Y. Bonnefoy, and S. Gordon. 1996. Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers. J. Exp. Med. 184:1927.
67. Szakal, A. K., K. L. Holmes, and J. G. Tew. 1983. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. J. Immunol. 131: 1714.