Antigen presentation and DNA vaccines

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 4 II, 2000, Pages

  Donnelly, John J ^a   Liu, Margaret A ^a   Ulmer, Jeffrey B ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; CELLULAR IMMUNITY; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; GENE TARGETING; GENETIC TRANSFECTION; IMMUNE RESPONSE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL;

EID: 0033762767     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.supplement_3.15tac10     Document Type: Conference Paper

References (39)

1. Direct gene transfer into mouse muscle in vivo
2. DNA vaccines
3. Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4
4. Cytotoxic T cell responses to DNA vaccination: Dependence on antigen presentation via class II MHC
5. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
6. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo
7. Immature dendritic cells phagocytose apoptotic cells via αv,β5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
8. Cytotoxic T cell immunity to virus-infected non-hematopoetic cells requires presentation of exogenous antigen
9. Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: Antigen presentation by non-muscle cells
10. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
11. Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
12. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
13. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen-presenting cells in the induction of cytotoxic T-lymphocyte responses by DNA vaccination
14. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
15. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming
16. Heat shock proteins transfer peptides during antigen processing and CTL priming
17. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter
18. Protective cellular immunity induced by DNA immunization: CTL responses against dominant and recessive epitopes of influenza virus nucleoprotein
19. Muscle-specific expression of hepatitis B surface antigen: No effect on DNA-raised immune responses
20. In vivo priming by DNA injection occurs predominantly by antigen transfer
21. DNA-based immunization by in vivo transfection of dendritic cells
22. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization
23. Induction of cytotoxic T lymphocytes and antitumor imunity with DNA vaccines expressing single T cell epitopes
24. Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells
25. Quantitative analysis of the immunopotency of genetically transfected dendritic cells
26. Immunization through dermal delivery of protein-encoding DNA: A role for migratory dendritic cells
27. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
28. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope
29. DNA immunization: Ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction
30. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigenpresenting cells
31. DNA vaccination: Transfection and activation of dendritic cells as key events for immunity
32. Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries
33. Cationic microparticles: A potent delivery system for DNA vaccines
34. Alphavirus vectors for gene expression and vaccines
35. Replicon-helper systems from attenuated venezuelan equine encephalitis virus: Expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo
36. DNA immunization against herpes simplex virus: Enhanced efficacy using a Sindbis virus-based vector
37. Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protects mice from lethal challenge
38. Sindbis virus DNA-based expression vectors: Utility for in vitro and in vivo gene transfer
39. Cancer therapy using a self-replicating RNA vaccine