Interleukin-15 mRNA is expressed by human keratinocytes, langerhans cells, and blood-derived dendritic cells and is downregulated by ultraviolet B radiation

Journal of Investigative Dermatology

Volumn 106, Issue 5, 1996, Pages 1047-1052

  Blauvelt, Andrew ^a   Asada, Hideo ^a   Klaus Kovtun, Vera ^a   Altman, David J ^a   Lucey, Daniel R ^a   Katz, Stephen I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytokines; Epidermis; RT PCR; Th1

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 15; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; KERATINOCYTE; LANGERHANS CELL; PRIORITY JOURNAL; ULTRAVIOLET B RADIATION;

EID: 0029883122     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12338641     Document Type: Article

References (34)

1. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154:483-490, 1995
2. Blauvelt A, Clerici M, Lucey DK, Steinberg SM, Yarchoan R, Walker R, Shearer GM, Katz SI: Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. J Immunol 154:3506-3515, 1995
3. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-771, 1988
4. Carson WE, Giri JG, Lindemann M, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenman J, Grabstein K, Caligiuri MA: Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395-1403, 1994
5. Cooper KD, Neises GR, Katz SI: Antigen-presenting OKM5+ melanophages appear in human epidermis after ultraviolet radiation. J Invest Dermatol 86:363-370, 1986
6. Enk CD, Katz SI: Extraction and quantitation of cytokine mRNA from human epidermal blister roofs. Arch Dermatol Res 287:72-77, 1994
7. Enk CD, Sredni O, Blauvelt A, Katz SI: Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 154:4851-4856, 1995
8. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D: Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13:2822-2830, 1994
9. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965-968, 1994
10. Hersey P, Haran G, Hansic E, Edwards A: Alteration of T cell subsets and induction of suppressor T cell activity in normal subjects after exposure to sunlight. J Immunol 131:171-174, 1983
11. Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH: Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 24:2271-2278, 1994
12. Kirnbauer RA, Kock A, Neuner P, Forster E, Krutmann J, Urbanski A, Schauer E, Ansel JC, Schwarz T, Luger TA: Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. J Invest Dermatol 96:484-489, 1991
13. Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, Luger TA: Human keratinocytes are a source for TNF-α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-1614, 1990
14. Kondo S, Kono T, Sauder DN, McKenzie RC: IL-8 gene expression and production in human keratinocytes and their modulation by UVB. J Invest Dermatol 101:690-694, 1993
15. Kripke ML: Ultraviolet radiation and immunology: something new under the sun-presidential address. Cancer Res 54:6102-6105, 1994
16. Kupper TS: The second decade of epidermal cytokines: an overview. In: Luger TA, Schwarz T (ed.). The Second Decade of Epidermal Cytokines: An Overview. Marcel Dekker, New York, 1993, pp 293
17. Kupper TS, Chua AO, Flood P, McGuire J, Gubler U: Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 80:430-436, 1987
18. Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331-339, 1995
19. Luger TA, Schwarz T: Epidermal cell derived secretory regulins. In: Schuler G (ed.). Epidermal Cell Derived Secretory Regulins. CRC, Inc., Boca Raton, FL, 1991, pp 217-251
20. Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh CS, Culpepper JA, Wysocka M, Trinchieri G, Murphy KM, O'Garra A: Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154:5071-5079, 1995
21. Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P, Callard R: Function of the interleukin-2 (IL-2) receptor γ-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15. Blood 85:38-42, 1995
22. Mohamadzadeli M, Takashima A, Dougherty I, Knop J, Bergstresser PR, Cruz PD: Ultraviolet B radiation tip-regulates the expression of IL-15 in human skin. J Immunol 155:4492-4496, 1995
23. Rivas JM, Ullrich SE: The rule of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation. J leukocyte Biol 56:769-775, 1994
24. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher H, Konwalinka G, Fritsch PO, Steinman RM, Schuler G: Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93, 1994
25. Romani N, Kamgen E, Koch F, Heufler C, Schuler G: Dendritic cell production of cytokines and responses to cytokines. Int Rev Immunol 6:151-161, 1990
26. Sallusto F, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis α. J Exp Med 179:1109-1108, 1994
27. Schmitt DA, Owen-Schaub L, Ullrich SE: Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 154:5114-5120, 1995
28. Schuler G (ed.), Epidermal Langerhans Cells, CRC, Inc., Boca Raton, FL, 1991, pp 324
29. Schwarz T, Luger TA: Pharmacology of cytokines in the skin. In: Mukhtar H (ed.). Pharmacology of Cytokines in the Skin. CRC, Inc., Boca Raton, FL, 1992, pp 283
30. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296, 1991
31. Steinman RM, Young JW: Signals arising from antigen-presenting cells. Curr Opin Immunol 3:361-372, 1991
32. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255-1259, 1995
33. Yoshikawa T, Rae V, Bruins-Slot W, Vanddenberg JW, Taylor JR, Streilein JW: Susceptibility to effects of UVB radiation on induction of contact hypersensitisity as a risk factor for skin cancer. J Invest Dermatol 95:530-536, 1990
34. Young JW, Koulava L, Sourgel SA, Clark EA, Steinman RM, Dupont B: The B7/BB11 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vivo. J Clin Invest 90:229-237, 1992