Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope

International Immunology

Volumn 13, Issue 4, 2001, Pages 451-458

  Feng, Carl G ^a   Demangel, Caroline ^a,b   Kamath, Arun T ^a   Macdonald, Murdo ^a   Britton, Warwick J ^a,c  

^a CENTENARY INSTITUTE   (Australia)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CD8+ T cells; Dendritic cell; Epitope; Mycobacteria; Vaccinia virus

Indexed keywords

ANTIMYCOBACTERIAL AGENT; BCG VACCINE; BROXURIDINE; CD1 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; MYCOBACTERIUM ANTIGEN; PEPTIDE DERIVATIVE; PLASMID DNA; RECOMBINANT INTERLEUKIN 2; RECOMBINANT VACCINE; SYNAPTOPHYSIN; THYMIDINE KINASE; TUNICAMYCIN; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL PROTECTION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG SPECIFICITY; DRUG TARGETING; FEMALE; IMMUNE RESPONSE; IMMUNOREACTIVITY; IN VITRO STUDY; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; TUBERCULOSIS CONTROL; VACCINIA VIRUS;

EID: 0035070170     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.4.451     Document Type: Article

References (37)

1. + T cells have only transiently dimunished levels of IFN-γ, yet succumb to tuberculosis
2. + T cells to acquired resistance
3. The protective immune response to Mycobacterium tuberculosis
4. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis
5. +, T cells in lungs following aerosol infection with Mycobacterium tuberculosis
6. + T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice
7. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice
8. + cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway
9. + CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages
10. Different effects of cytolytic T cell subsets on intracellular infection
11. + αβ T cell pool
12. + T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells
13. + T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection
14. b mice recognizing the 38 kDa antigen of Mycobacterium tuberculosis
15. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis
16. Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guerin-infected ice
17. Differential T cell responses to mycobacteria-secreted proteins distinguish vaccination with bacille Calmette-Guerin from infection with Mycobacterium turberculosis
18. Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis
19. Cloning and characterization of the gene for immunogenic protein MPB64 of Mycobacterium bovis BCG
20. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
21. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells
22. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection
23. + cells in tuberculosis
24. b mice
25. + T cells
26. + T lymphocytes specific for Mycobacterium tuberculosis
27. CTL response to Mycobacterium tuberculosis: Identification of an immunogenic epitope in the 19-kDa lipoprotein
28. + T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guerin-vaccinated mice
29. + T cells from patients with tuberculosis is related to the presence of pulmonary cavities
30. + T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection
31. + T cells
32. A new foreign policy: MCH class I molecules monitor the outside world
33. MHC class I-restricted CTL responses to exogenous antigens
34. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection
35. Dendritic cells and the control of immunity
36. Activation of human dendritic cells following infection with Mycobacterium tuberculosis
37. Susceptibility of mice deficient in CD1d or TAP1 to infection with Mycobacterium tuberculosis