Dendritic cells as regulators of immune reactivity: Implications for transplantation

Transplantation

Volumn 68, Issue 1, 1999, Pages 1-8

  Thomson, Angus W ^a   Lu, Lina ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CYTOKINE; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTATION; DENDRITIC CELL; GENETIC ENGINEERING; GRAFT REJECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOREGULATION; LEUKOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; PRIORITY JOURNAL; REVIEW;

EID: 0033565530     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199907150-00001     Document Type: Review

References (70)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245.
2. Lotze MT, Thomson AW. Dendritic cells. Biology and clinical applications. San Diego: Academic Press, 1999: 1.
3. Austyn JM, Hankins DF, Larsen CP, Morris PJ, Rao AS, Roake JA. Isolation and characterization of dendritic cells from mouse heart and kidney. J Immunol 1994; 52: 2401.
4. Larsen CP, Ritchie SC, Hendrix R, et al. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol 1994; 152: 5208.
5. Woo J, Lu L, Rao AS, et al. Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells. Transplantation 1994; 58: 484.
6. Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998; 392: 86.
7. + T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J Exp Med 1998; 187:1555.
8. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998; 188: 1359.
9. Shortman K, Caux C. Dendritic cell development: multiple pathways to nature's adjuvants. Stem Cells 1997; 15: 409.
10. Wu L, Li C-L, Shortman K. Thymic dendritic cell precursors: relationship to the T-lymphocytes lineage and phenotype of the dendritic cell progeny. J Exp Med 1996; 184: 903.
11. Jenkinson EJ, Jhittay P, Kingston R, Owen JJT. Studies of the role of the thymic environment in the induction of tolerance to MHC antigens. Transplantation 1985; 39: 331.
12. Matzinger P, Guerder S. Does T cell tolerance require a dedicated antigen-presenting cells? Nature 1989; 338: 74.
13. Inaba M, Inaba K, Hosono M, et al. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J Exp Med 1991; 173: 549.
14. Gao EK, Lo D, Sprent J. Strong T cell tolerance in parent->F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J Exp Med 1990; 171: 1101.
15. Widera G, Burkly LC, Pinkert CA, et al. Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: an in vivo approach to investigate Ia gene function. Cell 1987; 51: 175.
16. Oluwole SJ, Jin MX, Chowdhury NC, Engelstad K, Ohajekwe OA, James T. Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: evidence for the role of host antigen-presenting cells and suppressor cell mechanism. Cell Immunol 1995; 162: 33.
17. Brocker T, Riedinger M, Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997; 185: 541.
18. Steinman RM, Pack M, Inaba K. Dendritic cells in the T cell areas of lymphoid organs. Immunol Rev 1997; 156: 25.
19. Inaba K, Pack M, Inaba M, Sakuta H, Isdell F, Steinman RM. High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes. J Exp Med 1997; 186: 665.
20. Kronin V, Winkel K, Süss G, et al. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J Immunol 1996; 157: 3819.
21. Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Pas/Fas-ligand induced apoptosis. J Exp Med 1996; 183: 1789.
22. Fazekas de St Groth B. The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity. Immunol Today 1998; 19: 448.
23. Steptoe RJ, Thomson AW. Dendritic cells and tolerance induction. Clin Exp Immunol 1996; 105: 397.
24. Khoury SJ, Gallon L, Chen W, et al. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 1995; 182: 357.
25. Grabbe S, Steinbrink K, Steinert M, Luger TA, Schwarz T. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J Immunol 1995; 155: 4207.
26. Knight SC, Mertin J, Stackpoole A, Clark J. Induction of immune responses in vivo with small numbers of veiled (dendritic cells). Proc Natl Acad Sci USA 1983; 80: 6032.
27. Knight SC, Hunt R, Dore C, Medawar PB. Influence of dendritic cells on tumor growth. Proc Natl Acad Sci USA 1985; 82: 4495.
28. dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995; 60: 1539.
29. -) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplantation 1996; 62: 659.
30. Rastellini C, Lu L, Ricordi C, Starzl TE, Rao AS, Thomson AW. GM-CSF stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 1995; 60: 1366.
31. Saleem M, Sawyer GJ, Schofield RA, Seymour NO, Gustafsson K, Fabre JW. Discordant expression on major histocompatibility complex class II antigen and invariant chain in interstitial dendritic cells. Transplantation 1997; 64: 1134.
32. Grohmann U, Bianchi R, Ayroldi E, et al. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state. J Immunol 1997; 158: 3593.
33. Krasteva M, Kehren J, Horand F, et al. Duel role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation. J Immunol 1998; 160: 1181.
34. Khoury SJ, Gallon L, Verburg RR, et al. Ex-vivo treatment of antigen presenting cells with CTLA4-Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat. J Immunol 1996; 157: 3700.
35. Enk AH, Angeloni VL, Udey MC, Katz SI. Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 1993; 151: 2390.
36. De Smedt T, Van Mechelen M, De Becker G, Urbain J, Leo O, Moser M. Effect of interleukin-10 on dendritic cell maturation and function. Eur J Immunol 1997; 27: 1229.
37. Steinbrink K, Wölfl M, Jonuleit H, Knop J, Enk AH. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159: 4772.
38. Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159: 28.
39. Simon JC, Tigelaar RE, Bergstresser PR, Edelbaum D, Cruz PD. Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4 T helper cells. J Immunol 1991; 146: 485.
40. Gorczynski RM, Cohen Z, Fu X, Hua Z, Sun Y, Chen Z. Interleukin-13 in combination with antiinterleukin-12, increases graft prolongation after portal venous immunization with cultured allogeneic bone marrow-derived dendritic cells. Transplantation 1996; 62: 1592.
41. Gorczynski RG, Wojcik D. A role for nonspecific (cyclosporin A) or specific (monoclonal antibodies to ICAM-1, LFA-1, and IL-10) immunomodulation in the prolongation of skin allografts after antigen-specific pretransplant immunization or transfusion. J Immunol 1994; 152: 2011.
42. Khoury SJ, Sayegh MH, Hancock WW, Gallon L, Carpenter CB, Weiner HL. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J Exp Med 1993; 178: 559.
43. Morikawa Y, Tohya K, Matsuura N, Kakudo K. Different migration patterns of antigen-presenting cells correlate with Th1/ Th2-type responses in mice. Immunology 1995; 85: 575.
44. Clare-Salzler MJ, Brooks J, Chai AK, Anderson C. Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest 1992; 90: 741.
45. Chen W, Issazadeh S, Sayegh MH, Khoury SJ. In vivo mechanisms of acquired thymic tolerance. Cell Immunol 1997; 179: 165.
46. Chen W, Sayegh MH, Khoury SJ. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. J Immunol 1998; 160: 1504.
47. Lu L, Bonham CA, Chambers FD, et al. Induction of nitric oxide synthase in mouse dendritic cells by interferon-γ, endotoxin and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis. J Immunol 1996; 157: 3577.
48. Fehsel K, Kroncke KD, Meyer KL, Huber H, Wahnm V, Kolb-Bachofen V. Nitric oxide induces apoptosis in mouse thymocytes. J Immunol 1995; 155: 2858.
49. Lu L, Qian S, Hershberger PA, et al. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 1997; 158: 5676.
50. Thomas JM, Carver FM, Kasten-Jolly J, et al. Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation 1994; 57: 101.
51. Lu L, Li W, Fu F, et al: Blockade of the CD40-CD40L pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 1997; 64: 1808.
52. Buelens C, Willems E, Delvaux A, et al. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25: 2668.
53. Kaeamura T, Furue M. Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol 1995; 25: 1913.
54. Buelens C, Verhasselt V, De Groote D, Thielemans K, Goldman M, Willems F. Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10. Eur J Immunol 1997; 27: 1848.
55. Yasunori Y, Tsumura H, Miwa M, Inaba K. Contrasting effects of TGFβ1 and TNFα on the development of dendritic cells from progenitors in mouse bone marrow. Stem Cells 1997; 15: 144.
56. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155: 31.
57. Larsen CP, Morris PJ, Austyn JM. Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel route for initiation of rejection. J Exp Med 1990; 171: 307.
58. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M. Cell migration, chimerism, and graft acceptance. Lancet 1992; 339: 1579.
59. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
60. Lu L, Rudert WA, Qian S, et al. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J Exp Med 1995; 182: 379.
61. Bishop GA, Sun J, Ross Sheil AG, McCaughan GW. High-dose/ activation-associated tolerance. Transplantation 1997; 64: 1377.
62. Steptoe RJ, Fu F, Li W, et al. Augmentation of dendritic cells in murine organ donors by treatment with flt-3 ligand alters the balance between transplant tolerance and immunity. J Immunol 1997; 159: 5483.
63. Demetris AJ, Murase N, Ye Q, et al. Analysis of chronic rejection and obliterative arteriopathy. Am J Pathol 1997; 150: 563.
64. Markees T, Phillips N, Gordan E, et al. Prolongation of skin allograft survival in mice treated with FltS ligand induced dendritic cells and anti-CD154 monoclonal antibody. 17th World Congress of the Transplantation Society, Canada, Montreal, 1998, Abstract 285.
65. Hayamizu K, Zeng D, Huie P, Garcia-Ojeda M, Sibley RK, Strober S. Infusion of donor monocytes or DC precursors facilitates heart transplantation tolerance in rats after TLI (and ATG). 17th World Congress of the Transplantation Society, Montreal, Canada, 1998, Abstract 1407.
66. Gozzo J, Masli S, DeFazio S. Pulsed administration of donor dendritic cells to murine recipients treated with antilymphocyte Ab (anti-CD4 + anti CD8) promotes unresponsiveness to skin allografts. 17th World Congress of the Transplantation Society, Montreal, Canada, 1998, Abstract 1014.
67. Zhang HG, Liu D, Helke Y, et al. Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells. Nature Biotechnol 1998; 16: 1045.
68. Lu L, Gambotto A, Lee W-C, et al. Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients. Gene Ther 1999; 6: 554.
69. Lee W-C, Zhong C, Qian S, et al. Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGFβ. Transplantation 1998; 66: 1810.
70. Takayama T, Nishioka Y, Lu L, Lotze MT, Tahara H, Thomson AW. Retroviral delivery of viral IL-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T cell hyporesponsiveness. Transplantation 1998; 66: 1567.