A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1789-1796

  Süss, Gabriele ^a   Shortman, Ken ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL KILLING; CELL PROLIFERATION; CELL STIMULATION; DENDRITIC CELL; IMMUNE RESPONSE; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD8; ANTIGENS, CD95; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; DENDRITIC CELLS; FAS LIGAND PROTEIN; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS;

EID: 0029920922     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1789     Document Type: Article

References (26)

1. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immun. 9:271-296.
2. Knight, S.C., and A.J. Stagg. 1993. Antigen-presenting cell types. Curr. Opin. Immunol. 5:374-382.
3. Austyn, J.M. 1992. Antigen uptake and presentation by dendritic leukocytes. Semin. Immunol. 4:227-236.
4. Metlay, J.P., M.D. Witmer-Pack, R. Agger, M.T. Crowley, D. Lawless, and R.M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753-1771.
5. Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shortman. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176:47-58.
6. Wu, L., D. Vremec, C. Ardavin, K. Winkel, G. Süss, H. Georgiou, E. Maraskovsky, W. Cook, and K. Shortman. 1995. Mouse thymus dendritic cells: kinetics of de velopment and changes in surface markers during maturation. Eur. J. Immunol. 25:418-425.
7. Singer, G.G., and A.K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:365-371.
8. Krammer, P.H., I. Behrmann, P. Daniel, J. Dhein, and K.-M. Debatin. 1994. Regulation of apoptosis in the immune system. Curr. Opin. Immunol. 6:279-289.
9. Nagata, S., and P. Golstem. 1995. The Fas death factor. Science (Wash. DC). 267:1449-1456.
10. Lynch, D.H., M.L. Watson, M.R. Alderson, P.R. Baum, R.E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C.A. Smith, K. Hunter et al. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity. 1:131-136.
11. Ju, S.-T., D.J. Panka, H. Cul, R. Ettinger, M. El-Khatib, D.H. Sherr, B.Z. Stanger, and A. Marshak-Rothstein. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (Lond.). 373:444-448.
12. Dhein, J., H. Walczak, C. Bäumler, K.-M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature (Lond.). 373:438-441.
13. Brunner, T., R.J. Mogil, D. LaFace, N.J. Yoo, A. Mahboubi, F. Echeverri, S.J. Martin, W.R. Force, D.H. Lynch, C.F. Ware, and D.R. Green. 1995. Cell-autonomous Fas (CD95)/ Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (Lond.). 373:441-444
14. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond.). 356:314-317.
15. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lympboproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76:969-976.
16. Gillette-Ferguson, I., and C.L. Sidman. 1994. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. Eur. J. Immunol. 24:1181-1185
17. Russell, J.H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA. 90:4409-4413.
18. + single positive cells with a class II major histocompatibility complex - restricted receptor. J. Exp. Med. 180:25-34.
19. Nagata, S., and T. Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Immunol. Today. 16:39-43.
20. Sgonc, R., G. Boeck, H. Dietrich, J. Gruher, H. Recheis, and G. Wick. 1994. Simultaneous determination of cell surface antigens and apoptosis. Trends Genet. 10:41-42.
21. Inaba, M., K. Inaba, M. Hosono, T. Kumamoto, T. Ishida, S. Muramatsu, T. Masuda, and S. Ikehara. 1991. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J. Exp. Med. 173:549-560.
22. Crispe, I.N. 1994 Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity. 1:347-349.
23. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 75:1169-1178.
24. Ardavin, C., L. Wu, C.-L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor. Nature (Lond.). 362:761-763.
25. Bellgrau, D., D. Gold, H. Selawry, J. Moore, A. Franzusoff, and R.C. Duke. 1995. A role for CD95 ligand in preventing graft rejection. Nature (Lond.). 377:630-632.
26. Griffith, T.S., T. Brunner, S.M. Fletscher, D.R. Green, and T.A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune priviledge. Science (Wash. DC). 270:1189-1192.