Cutting edge: Cytokines regulate expression and function of the HIV coreceptor CXCR4 on human mature dendritic cells

Journal of Immunology

Volumn 161, Issue 7, 1998, Pages 3219-3223

  Zoeteweij, J Paul ^a   Golding, Hana ^b   Mostowski, Howard ^b   Blauvelt, Andrew ^a,c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CD4 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA1; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LANGERHANS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNCYTIUM; T LYMPHOCYTE ACTIVATION; VIRUS ENVELOPE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; GIANT CELL; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; GIANT CELLS; HIV; HIV INFECTIONS; HUMANS; LANGERHANS CELLS; RECEPTORS, CCR5; RECEPTORS, CXCR4;

EID: 0032185495     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Deng, H., R. Liu, W. Ellmeie, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Suton, C. M. Hill. C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661.
2. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodrowski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135.
3. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667.
4. Feng, Y., C. Broder, P. E. Kennedy, and E. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872.
5. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C.-M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonboy, M. Georges, T. Imai, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722.
6. Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allimets, J. J. Goedert, S. P. Buchbinder, E. Vittinghof, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856.
7. Winkler, C., W. Modi, M. W. Smith, G. W. Nelson, X. Wu, M. Carrington, M. Dean, T. Honjo, K. Tashiro, D. Yabe, S. Buchbinder, E. Vittinghof, J. J. Goedert, T. R. O'Brien, L. P. Jacobson, et al. 1998. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science 279:389.
8. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
9. Blauvelt, A., H. Asada, W. M. Saville, V. Klaus-Kovtun, D. J. Altman, R. Yarchoan, and S. I. Katz. 1997. Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways. J. Clin. Invest. 100: 2043.
10. Zoeteweij, J. P., and A. Blauvelt. 1998. HIV-dendritic cell interactions promote efficient viral infection of T cells. J. Blamed. Sci. 5:253.
11. Spira, A. I., P. A. Marx, B. K. Patterson, J. Mahoney, R. A. Koup, S. M. Wolinsky, and D. D. Ho. 1996. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J. Exp. Med. 183:215.
12. Zaitseva, M., A. Blauvelt, S. Lee, C. K. Lapham, V. Klaus-Kovtun, H. Mostowski, J. Manischewitz, and H. Golding. 1997. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat. Med. 3:1369.
13. Pantaleo, G., C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355.
14. Embretson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and H. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362:359.
15. Blauvelt, A., M. Clerici, D. R. Lucey, S. M. Steinberg, R. Yarchoan, R. Walker, G. M. Shearer, and S. I. Katz. 1995. Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. J. Immunol. 154:3506.
16. Granelli-Piperno, A., E. Delgado, V. Finkel, W. Paxton, and R. M. Steinman. 1998. Immature dendritic cells selectively replicate macrophage tropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells. J. Virol. 72: 2733.
17. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Y. Chen. 1990. HIV-entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213.
18. Blauvelt, A., S. Sei, P. M. Cook, T. F. Schultz, and K.-T. Jeang. 1997. Human herpesvirus 8 infection occurs following adolescence in the United States. J. Infect. Dis. 176:771.
19. Signoret, N., J. Oldridge, A. Pelchen-Matthews, P. J. Klasse, T. Tran, L. F. Brass, M. M. Rosenkilde, T. W. Schwartz, W. Holmes, W. Dallas, M. A. Luther, T. N. C. Wells, J. A. Hoxie, and M. Marsch. 1997. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell Biol. 139:651.
20. Ludewig, B., D. Graf, H. R. Gelderblom, Y. Becker, R. A. Kroczek, and G. Pauli. 1995. Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-α, but strongly enhanced by interleukin-10. Eur. J. Immunol. 25(7):1943.