The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

Nature Immunology

Volumn 2, Issue 3, 2001, Pages 203-209

  Coyle, Anthony J ^a   Gutierrez Ramos, Jose Carlos ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; B7 ANTIGEN; B7 RELATED PROTEIN 1; B7-RELATED PROTEIN-1; CD28 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; CD86 PROTEIN, MOUSE; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; ISOPROTEIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; FORECASTING; GENETICS; HELPER CELL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MOUSE; PHYLOGENY; REVIEW;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; CYTOKINES; FORECASTING; HUMANS; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MEMBRANE GLYCOPROTEINS; MICE; MODELS, IMMUNOLOGICAL; PHYLOGENY; PROTEIN ISOFORMS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0035292756     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/85251     Document Type: Review

References (73)

1. Bretscher, P. A. & Cohn, M. A theory of self and non self discrimination. Science, 169, 1042-1049 (1970).
2. Lafferty, J. & Woolnough, J. A. The origin and mechanism of the allograft reaction. Immunol. Rev. 35 231-249 (1977).
3. Schwartz, R. H. A cell culture model for T lymphocyte clonal anergy. Science 4961, 1349-1356 (1990).
4. Garside, P. et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281, 96-99 (1998).
5. Klaus, G. G. B., Humphret, J. H., Kunkl, A. & Dongworth, D. W. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53, 3-28 (1980).
6. Aruffo, A. & Seed, B. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl Acad. Sci. USA 84, 8573-8577 (1987).
7. June, C. H., Ledbetter, J. A., Gillespie, M. M., Lindsten, T. & Thompson, C. B. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 12., 4472-4481, (1987)
8. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H. & Allison, J. P. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 6370, 607-609 (1992).
9. Jenkins, M. K., Taylor, P. S., Norton, S. D. & Urdahl, K. B. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 8, 2461-2466 (1991).
10. Lucas, P. J., Negishi, I., Nakayama, K., Fields, L. E. & Loh, D. Y. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154, 5757-5768. (1997)
11. Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-612 (1993).
12. Tada, Y. et al. CD28-deficient mice are highly resistant to collagen-induced arthritis. J. Immunol. 162, 203-208 (1999).
13. Girvin, A. M. et al. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J. Immunol. 64, 136-143 (2000).
14. Mathur, M. et al. CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice. Am. J. Respir. Cell Mol. Biol. 21, 498-509 (1999).
15. Brunet J. F. et al. A new member of the immunoglobulin super-family CTLA-4. Nature 328, 267-270 (1987).
16. Walunas, T. L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
17. Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
18. Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
19. Luhder, F., Hoglund, P., Allison, J. P., Benoist, C. & Mathis, D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187, 427-432 (1998).
20. Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 4, 411-117 (1997).
21. Yokochi, T., Holly, R. D. & Clark, E. A. B lymphoblast antigen (BB-1) expressed on Epstein Barr virus activated B cell blasts, b lymphoblastoid cell lines and Burkitts lymphomas. J. Immunol. 128, 823-827 (1982)
22. Freedman, A. S., Freeman, G., Horowitz, J. C., Daley, J. & Nadler, L. B7, a B-cell-restricted antigen that identifies preactivated B cells. J. Immunol. 139, 3260-3267 (1987).
23. Freeman, G. J. et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262, 907-909 (1993).
24. Kozono, Y., Abe, R., Kozono, H., Kelly, R. G., Azuma, T. & Holers, V. M. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J. Immunol. 160, 1565-1572 (1998).
25. Ikemizu S. et al. Structure and dimerization of a soluble form of B7-1. Immunity 12, 51-60 (2000).
26. Sethna, M. P, van Parijs, L., Sharpe, A. H., Abbas, A. K. & Freeman, G. J. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity 1, 415-421 (1994).
27. Khattri, R., Auger, J. A., Griffin, M. D., Sharpe, A. H. & Bluestone, J. A. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J. Immunol. 162, 5784-5791. (1999).
28. Oosterwegel, M. A. et al., The role of CTLA-4 in regulating Th2 differentiation. J. Immunol. 163, 2634-2639 (1999).
29. Corry, D. B., Reiner, S. L., Linsley, P. S. & Locksley, R. M. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 9, 4142-4148 (1994).
30. Linsley, P. S. et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257, 792-795 (1992).
31. Lenschow, D. J. et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 3, 285-293 (1996).
32. Sayegh, M. H. et al. LACD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 5, 1869-1874 (1995).
33. Freeman, G. J. et al. B7-1 and B7-2 do not deliver identical costimulatory signals, because B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 5, 523-532 (1995).
34. Kuchroo, V. K. et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 10, 707-718 (1995).
35. Bird, J. J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229-237 (1998).
36. Randolph, D. A., Huang, G., Carruthers, C. J., Bromley, L. E. & Chaplin, D. D. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo. Science 286, 2159-2162 (1999).
37. D' Ambrosio, D. et al. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161, 5111-5115 (1998).
38. + immunoregulatory T cells that control autoimmune diabetes. Immunity 4, 431-440 (2000).
39. Schweitzer, A. N. & Sharpe, A. H. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J. Immunol. 6, 2762-2771 (1998).
40. Corry, D. B., Reiner, S. L., Linsley, P. S., Locksley, R. M. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 9, 4142-4148 (1994).
41. Tang, A., Judge, T. A., Nickoloff, B. J. & Turka, L. A. Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40 - ligand. J. Immunol. 1, 117-125 (1996).
42. Gause, W. C. et al. Polygyrus: B7-independence of the secondary type 2 response. Exp. Parasitol. 84, 264-273 (1996).
43. London, C. A., Lodge, M. P. & Abbas, A. K. Functional responses and costimulator dependence of memory CD4+ T cells. J. Immunol. 164, 265-272 (2000).
44. Henry, J., Miller, M. M. & Pontarotti, P. Structure and evolution of the extended B7 Family. Immunol. Today 6, 285-288 (1999).
45. Swallow, M. M., Wallin, J. J. & Sha, W. C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα. Immunity 11, 423-432 (1999).
46. Yoshinaga, S. K. et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402, 827-832 (1999).
47. Aicher, A. et al. Characterization of human inducible costimulator ligand expression and function. J. Immunol. 164, 4689-4696. (2000).
48. Yoshinaga, S. K. et al. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int. Immunol. 10, 1439-1447 (2000).
49. Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 6716, 263-267 (1999).
50. Coyle, A. J. et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 1, 95-105 (2000).
51. McAdam, A. J. et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4(+) T cells. J. Immunol. 165, 5035-5040 (2000).
52. Kopf, M. et al. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J. Exp. Med. 192, 111-117 (2000)
53. Dong, C. et al. ICOS costimulatory receptor is essential for T-cell activation and function Nature 409, 97-101 (2001).
54. McAdam, A. J. et al. ICOS is critical for CD40 mediated antibody class Switching. Nature, 409, 102-105 (2001).
55. Tafuri, A. et al. Essential role of ICOS in effective helper T cell responses. Nature 409, 105-109, (2001).
56. Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1 a third member of the B7 family, costimulates T cell proliferation and interleukin 10 secretion. Nature Med. 5, 1365-1369 (1999).
57. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192 1027-1034 (2000).
58. Ishida, Y., Agata, Y., Shibahara, K. & Honjo, I. Induced expression of PD1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887-3895 (1996).
59. Latchman, Y. et al. PD-L2 is a second ligand for PD-1 and inhibits T cells activation. Nature Immunol. 2, 261-268 (2001).
60. Kingsbury, G. et al. Identification and expression of the fifth member of the B7 family as a second ligand for programmed death - I that inhibits cytokine production from T cells. J. Exp. Med. (in press the press, 2001).
61. Nishimura, H., Minato, N., Nakano, T. & Honjo, T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 101563-10172 (1998).
62. Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
63. Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996)
64. Chapoval, A. I. et al. B7-H3: A costimulatory molecule for T cell activation and IFN-γ production. Nature Immunol. 2, 269-274 (2001)
65. Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 92, 245-249 (1998).
66. Cella, M., Sallusto, F. & Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9, 10-16 (1997).
67. Gonzalo, J. A., Delaney, T., Corcoran, J., Gutierrez-Ramos, J. C. & Coyle, A. J. Complimentary and unique signals delivered by ICOS and CD23 regulate T cell effector function. J. Immunol. 166, 1-5 (2001).
68. Hur, D. Y. et al. Role of follicular dendritic cells in the apoptosis of germinal center B cells. Immunol. Lett. 72, 107-111 (2000).
69. Li, L. et al. Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell growth. J. Exp. Med. 191, 1077-1084 (2000).
70. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
71. Schaerli, P. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562 (2000).
72. Breitfeld D. et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192, 1545-1552 (2000).
73. Mackay, C. R. Follicular homing T helper (Th) cells and the Th1/Th2 paradigm. J. Exp. Med. 192, 31-34 (2000).