T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice

Journal of Clinical Investigation

Volumn 101, Issue 6, 1998, Pages 1398-1407

  Valujskikh, Anna ^a   Matesic, Damir ^a   Gilliam, Anita ^a   Anthony, Donald ^a   Haqqi, Tarriq M ^a   Heeger, Peter S ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

Cellular immunity; Cytokines; Graft rejection; T lymphocytes; Transplantation immunology

Indexed keywords

CD4 ANTIGEN; CYTOKINE;

ADOLESCENT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; FEMALE; GRAFT REJECTION; HISTOCOMPATIBILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; T LYMPHOCYTE;

EID: 0032521390     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI893     Document Type: Article

References (32)

1. Rosenberg, A., and A. Singer. 1992. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. Annu. Rev. Immunol. 10:333-358.
2. Rosenberg, A. 1991. Skin allograft rejection. In Current Protocols in Immunology. Vol. 1. J. Coligan, A. Kruisbeek, D. Margulies, E. Shevach, and W. Strober, editors. John Wiley & Sons Inc., Bethesda. 4.4.1-1.4.9.
3. Sayegh, M., B. Watschinger, and C. Carpenter. 1994. Mechanisms of T cell recognition of antigen. Transplantation (Baltimore). 57:1295-1302.
4. Fangmann, F., R. Dalchau, G. Sawyer, C. Priestley, and J. Fabre. 1992. T cell recognition of donor major histocompatibility complex class I peptides during allograft rejection. Eur. J. Immunol. 22:1525-1530.
5. Auchincloss, H., Jr., R. Lee, S. Shea, J. Markowitz, M. Grusby, and L. Glimcher. 1993. The role of indirect recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc. Natl. Acad. Sci. USA. 90:3373-3377.
6. Benichou, G., P. Takizawa, C. Olson, M. McMillan, and E. Sercarz. 1992. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J. Exp. Med. 175:305-308.
7. Benichou, G., E. Fedoseyeva, P. Lehmann, C. Olson, H. Geysen, M. McMillan, and E. Sercarz. 1994. Limited T cell response to donor MHC peptides during allograft rejection. J. Immunol. 153:938-945.
8. Liu, Z., Y. Sun, Y. Xi, A. Maffei, E. Reed, P. Harris, and N. Suciu-Foca. 1993. Contribution of direct and indirect recognition pathways to T cell alloreactivity. J. Exp. Med. 177:1643-1650.
9. Lee, R., M. Grusby, L. Glimcher, H. Winn, and H. Auchincloss. Jr. 1994. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J. Exp. Med. 179:865-872.
10. Sayegh, M., N. Perico, L. Gallon, O. Imherti, W. Hancock, G. Remuzzi, and C. Carpenter. 1994. Mechanisms of acquired thymic unresponsiveness to renal allografts: thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation (Baltimore). 58:125-132.
11. Sayegh, M., N. Perico, O. Imberti, W. Hancock, C. Carpenter, and G. Remuzzi. 1993. Thymic recognition of class II MHC allopeptides induces donor-specific unresponsiveness to renal allografts. Transplantation (Baltimore). 56:461-465.
12. Oluwole, S., M. Jin, N. Chowdhury, and O. Ohajekwe. 1994. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression. Transplantation (Baltimore). 58:1077-1081.
13. Oluwole, S., N. Chowdhury, M. Jin, and M. Hardy. 1993. Induction of transplantation tolerance in rat cardiac allografts by intrathymic inoculation of allogeneic soluble peptides. Transplantation (Baltimore). 56:1523-1527.
14. Sayegh, M., and A. Krensky 1996. Novel immunotherapeutic strategies using MHC derived peptides. Kidney Int. 49:S13-S20.
15. Dalloul, A., E. Chmouzis, K. Ngo, and W. Fung-Leung. 1996. Adoptively transferred CD4+ lymphocytes from CD8-/-mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts. J. Immunol. 156:4114-4119.
16. Wecker, H., M. Grusby, and H. Auchincloss, Jr. 1995. Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation (Baltimore). 59:1223-1227.
17. Lehmann, P.V., D. Matesic, G. Benichou, and P.S. Heeger. 1997. Induction of T helper 2 immunity to an immunodominant allopeptide. Transplantation (Baltimore). 64:292-296.
18. Heeger, P.S., W.E. Smoyer, T. Saad, S. Albert, C.J. Kelly, and E.G. Neilson. 1994. Molecular analysis of the helper T cell response in murine interstitial nephritis. J. Clin. Invest. 94:2084-2092.
19. Haqqi, T., X. Qu, M. Sy, and S. Banerjee. 1995. Restricted expression of T cell receptor V beta and lymphokine genes in arthritic joints of a TCR V beta a (H-2q) mouse strain-BUB/BnJ-wilh collagen-induced arthritis. Autoimmunity. 20:163-170.
20. Heeger, P., W. Smoyer, M. Jones, S. Hopfer, and E. Neilson. 1996. Heterogeneous T cell receptor Vβ gene repertoire in murine interstitial nephritis. Kidney Int. 49:1222-1230.
21. Ortman, R., D. Holderbaum, X. Ou, S. Banerjee, and T. Haqqi. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a. KJ16-) that is susceptible to type II collagen-induced arthritis. J. Immunol. 152:4175-4182.
22. Matzinger, P. 1991. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods. 145:185-192.
23. Strom, T., P. Roy-Chaudhury, R. Manfro, X. Zheng, P. Nickerson, and K, Wood. 1996. The Th1/Th2 paradigm and the allograft response. Curr. Opin. Immunol. 8:688-693.
24. Larsen, C., E. Elwood, D. Alexander, S. Ritchie, R. Hendrix, C. TuckerBurden, H. Cho, A. Aruffo, D. Hollenbaugh, P. Linsley, et al. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 381:434-438.
25. Russell, M., W. Hancock, E. Akalin, and A. Wallace. 1996. Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA41g modulates T cell and macrophage activation and attenuates arteriosclerosis. J. Clin. Invest. 97:833-838.
26. Orosz, C.G., E. Wakely, S.D. Bergese, A.M. VanBuskirk, R.M. Ferguson, D. Mullet, G. Apseloff, and N. Gerber. 1996. Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anli-CD4 monoclonal antibody. Transplantation (Baltimore). 61:783-791.
27. Risch, K., U. Heemann, E. Graser, B. Nebe, H. Nizze, J. Lacha, J. Brock, H. Volk, and M. Lehmann. 1996. Assessment of chronic rejection in permanent accepted renal allografts in anti-CD4 treated rats. Clin. Nephrol. 45: 358-360.
28. Chen, W., B. Murphy, A. Waaga, T. Willett, M. Russell, S. Khoury, and M. Sayegh. 1996. Mechanisms of indirect allorecognition in graft rejection. Class II MHC allopeptide-specific T cell clones transfer delayed-type hypersensitivity in vivo. Transplantation (Baltimore). 62:705-710.
29. Halloran, P., A. Wadgymar, and P. Autenfried. 1986. The regulation of expression of major histocompatibility complex products. Transplantation (Baltimore). 41:413-420.
30. Kondo, T., A. Novick, H. Toma, and R. Fairchild. 1996. Induction of chemokine gene expression during allogeneic skin graft rejection. Transplantation (Baltimore). 61:1750-1757.
31. Border, W., and N. Noble. 1994. Transforming growth factor-β in tissue fibrosis. N. Engl. J. Med. 331:1286-1292.
32. Agarwal, A., Y. Kin, A. Matas, J. Alam, and K. Nath. 1996. Gas-generating systems in acute renal allograft rejection in the rat. Coinduction of heme oxygenase and nitric oxide synthase. Transplantation (Baltimore). 61:93-98.