Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 4090-4097

  Lambrecht, Bart N ^a   Salomon, Benoît ^b   Klatzmann, David ^b   Pauwels, Romain A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GANCICLOVIR; IMMUNOGLOBULIN E; THYMIDINE KINASE;

AIRWAY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FLOW CYTOMETRY; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ADMINISTRATION, INHALATION; ANIMALS; ANTIGENS; ASTHMA; B-LYMPHOCYTES; BRONCHOALVEOLAR LAVAGE FLUID; DENDRITIC CELLS; EOSINOPHILIA; EOSINOPHILS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN; T-LYMPHOCYTE SUBSETS;

EID: 0032522829     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Robinson, D. R., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant Th2-like bronchoalveolar T lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
2. Janeway, C. A., Jr., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
3. Thompson, C. B. 1995. Distinct roles for the co-stimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell 81:979.
4. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
5. Inaba, K., J. P. Metlay, M. T. Crowley, and R. M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen specific, MHC-restricted T cells in situ. J. Exp. Med. 172:631.
6. Stingl, G., and P. R. Bergstresser. 1995. Dendritic cells: A major story unfolds. Immunol. Today 16:330.
7. Larsen, C. P., S. C. Ritchie, R. Hendrix, P. S. Linsley, K. S. Hathcock, R. J. Hodes, R. P. Lowry, and T. C. Pearson. 1994. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152:5208.
8. Croft, M., L. M. Bradley, and S. L. Swain. 1994. Naive versus memory CD4 T cell response to antigen: memory cells are less dependent on accessory cell co-stimulation and can respond to many APC types including resting B cells. J. Immunol. 152:2675.
9. + T cells differing in CD45R expression. J. Immunol. 149:2300.
10. Schon-Hegrad, M. A., J. Oliver, P. G. McMenamin, and P. G. Holt. 1991. Studies on the density, distribution and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J. Exp. Med. 173:1345.
11. Gong, J. L., K. M. McCarthy, J. Telford, T. Tamatani, M. Miyasaka, and E. Schneeberger. 1992. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J. Exp. Med. 175:797.
12. Holt, P. G., M. A. Schon-Hegrad, J. Oliver, B. J. Holt, and P. G. McMenamin. 1990. A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium. Int. Arch. Allergy Appl. Immunol. 91:155.
13. Havenith, C. E. G., A. J. Breedijk, M. G H. Betjes, W. Calame, R. H. J. Beelen, and E. C. M. Hoefsmit. 1993. T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells. Am. J. Respir. Cell Mol. Biol. 8:319.
14. + dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen. J. Exp. Med. 181:1275.
15. Masten, B. J., J. L. Yates, A. M. P. Koga, and M. F. Lipscomb. 1997. Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L. Am. J. Respir. Cell Mol. Biol. 16:335.
16. Brusselle, G. G., J. C. Kips, J. Tavernier, J. G. Van Der Heyden, C. A. Cuvelier, R. A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 24:73.
17. Kips, J. C., G. G. Brusselle, G. F. Joos, R. A. Peleman, J. Tavernier, R. Devos, and R. A. Pauwels. 1996. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 153:535.
18. Brusselle, G. G., J. C. Kips, G. F. Joos, H. Bluethmann, and R. A. Pauwels. 1995. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 12:254.
19. Salomon, B., P. Lorès, C. Pioche, P. Racz, J. Jami, and D. Klatzmann. 1994. Conditional ablation of dendritic cells in transgenic mice. J. Immunol. 152:537.
20. Salomon, B., C. Pioche, P. Lorès, J. Jami, P. Racz, and D. Klatzmann. 1995. Conditional ablation of dendritic cells in mice: comparison of two animal models. In Dendritic Cells in Fundamental and Clinical Immunology. D. Schmitt, ed. Plenum Press, New York, p. 485.
21. Brokaw, J. J., G. P. Anderson, P. Baluk, E. Y. Umemoto, and D. M. McDonald. 1996. Glucocorticosteroid treatment reduces the number of dendritic cells in the rat tracheal mucosa. Am. J. Respir. Crit. Care Med. 153:141.
22. Armitage, P., and G. Berry. 1987. Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford, U.K., p. 411.
23. Holt, P. G., S. Haining, D. J. Nelson, and J. D. Sedgwick. 1994. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J. Immunol. 153:256.
24. Leenen, P. J. M., K. Radosevic, J. S. A. Voerman, B. Salomon, N. Van Rooijen, D. Klatzmann, and W. van Ewijk. 1998. Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers and subpopulation turnover. J. Immunol 160:2166.
25. Wu, L., C. L. Li, and K. Shortman. 1996. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184:903.
26. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
27. Okada, H., T. Ohnishi, M. Hirashima, J. Fujita, Y. Yamaji, J. Takahara, and T. Todani. 1997. Anti-asthma effect of an antiviral drug, acyclovir: a clinical case and experimental study. Clin. Exp. Allergy 27:431.
28. Harris, N., R. Peach, J. Naemura, P. S. Linsley, G. Le Gros, and F. Ronchese. 1997. CD80 costimulation is essential for the induction of airway eosinophilia. J. Exp. Med. 185:177.
29. Tsuyuki, S., J. Tsuyuki, K. Einsle, M. Kopf, and A. J. Coyle. 1997. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J. Exp. Med. 185:1671.
30. Keane-Myers, A., W. C. Gause, P. S. Linsley, S. Chen, and M. Wills-Karp. 1997. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J. Immunol. 158:2042.
31. Gause, W. C., V. Mitro, C. Via, P. Linsley, J. F. Urban, and R. J. Greenwald. 1997. Do effector and memory T helper cells also need B7 ligand co-stimulatory signals? J. Immunol. 159:1055.
32. Mackay, C. R., W. L. Marston, and L. Dudler 1990: Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171:801.
33. Westermann, J., S. Persin, J. Matyas, P. Van Der Meide, and R. Pabst. 1994. Migration of so-called naive and memory T lymphocytes from blood to lymph in the rat. J. Immunol. 152:1744.
34. Westermann, J., and R. Pabst. 1996. How organ specific is the migration of naive and memory T cells? Immunol. Today 17:278.
35. Thepen, T., C. McMenamin, B. Girn, G. Kraal, and P. G. Holt 1992. Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen. Clin. Exp. Allergy 22:1107.
36. Holt, P. G. 1985. Downregulation of immune responses in the lower respiratory tract: role of alveolar macrophages. Clin. Exp. Immunology 63:261.
37. Korsgren, M., J. S. Erjefält, O. Korsgren, F. Sundler, and C. G. A. Persson. 1997. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J. Exp. Med. 185:885.
38. Moller, G. M., S. E. Overbeek, C. G. VanHeldenMeeuwsen, J. M. W. VanHaarst, E. P. Prens, P. G. Mulder, D. S. Postma, and H. C. Hoogsteden. 1996. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin. Exp. Allergy 26:517.
39. Tunon de Lara, J. M., A. E. Redington, P. Bradding, M. K. Church, J. A. Hartley, A. E. Semper, and S. T. Holgate. 1996. Dendritic cells in normal and asthmatic airways: expression of the α subunit of the high affinity immunoglobulin E receptor. Clin. Exp. Allergy 26:648.
40. Semper, A. E., and J. A. Hartley. 1996. Dendritic cells in the lung: what is their relevance to asthma? Clin. Exp. Allergy 26:485.
41. Nelson, D. J., A. S. McWilliam, S. Haining, and P. G. Holt 1995. Modulation of airway intraepithelial dendritic cells following exposure to steroids. Am. J. Respir. Crit. Care Med. 151:475.