Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes

Journal of Immunology

Volumn 161, Issue 5, 1998, Pages 2223-2231

  Dubois, Bertrand ^a   Massacrier, Catherine ^a   Vanbervliet, Béatrice ^a   Fayette, Jérome ^a   Brière, Francine ^a   Banchereau, Jacques ^a,b   Caux, Christophe ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN M; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, BLOCKING; ANTIGENS, CD40; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DRUG SYNERGISM; FETAL BLOOD; HUMANS; IMMUNE SERA; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-12; INTERLEUKIN-2; PLASMA CELLS; RECEPTORS, INTERLEUKIN-6; SOLUBILITY;

EID: 0032167549     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
2. Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
3. Inaba, K., M. D. Witmer, and R. M. Steinman. 1984. Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells, during primary antibody responses in vitro. J. Exp. Med. 160:858.
4. Inaba, K., A. Granelli-Piperno, and R. M. Steinman. 1983. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and man. Proc. Natl. Acad. Sci. USA 80:6041.
5. Inaba, K., J. P. Metlay, M. T. Crowley, and R. M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172:631.
6. Sornasse, T., V. Flamand, G. de Becker, H. Bazin, F. Tielemans, K. Thielemans, J. Urbain, L. Oberdan, and M. Moser. 1992. Antigen-pulse dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 175:15.
7. Flamand, V., T. Sornasse, K. Thielemans, C. Demanet, M. Bakkus, H. Bazin, F. Tielemans, O. Leo, J. Urbain, and M. Moser. 1994. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24:605.
8. Caux, C., N. Burdin, L. Galibert, P. Hermann, N. Renard, C. Servet-Delprat, and J. Banchereau. 1994. Functional CD40 on B lymphocytes and dendritic cells. Res. Immunol. 145:235.
9. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
10. Liu, Y. J., D. E. Joshua, G. T. Williams, C. A. Smith, J. Gordon, and I. C. M. MacLennan. 1989. Mechanisms of antigen-driven selection in germinal centers. Nature 342:929.
11. Banchereau, J., P. de Paoli, A. Vallé, E. Garcia, and F. Rousset. 1991. Long term human B cell lines dependent on interleukin 4 and antibody to CD40. Science 251:70.
12. Jabara, H. H., S. M. Fu, R. S. Geha, and D. Vercelli. 1990. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172:1861.
13. Rousset, F., E. Garcia, and J. Banchereau. 1991. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J. Exp. Med. 173:705.
14. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J. P. Galizzi, C. van Kooten, Y. J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
15. Callard, R. E., R. J. Armitage, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559.
16. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune response in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
17. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
18. Caux, C., and J. Banchereau. 1996. In vitro regulation of dendritic cell development and function. In Blood Cell Biochemistry. T. Whetton and J. Gordon, eds. Plenum Press, London, p. 263.
19. O'Doherty, U., M. Peng, S. Gezelter, W. J. Swiggard, M. Betjes, N. Bhardwaj, and R. M. Steinman. 1994. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82:487.
20. Grouard, G., I. Durand, L. Filgueira, J. Banchereau, and Y. J. Liu. 1996. Dendritic cells capable of stimulating T cells in germinal centers. Nature 384:364.
21. Grouard, G., M. C. Rissoan, L. Filgueira, I. Durand, J. Banchereau, and Y. J. Liu. 1997. The enigmatic plasmacytoid T cells develop into dendritic cells with IL-3 and CD40-ligand. J. Exp. Med. 185:1101.
22. Dubois, B., B. Vanbervliet, J. Fayette, C. Massacrier, C. van Kooten, F. Brière, J. Banchereau, and C. Caux. 1997. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med. 185:941.
23. Fayette, J., B. Dubois, S. Vandenabeele, J. M. Bridon, B. Vanbervliet, I. Durand, J. Banchereau, C. Caux, and F. Brière. 1997. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J. Exp. Med. 185:1909.
24. Pinchuk, L. M., S. J. Klaus, D. M. Magaletti, G. V. Pinchuk, J. P. Norsen, and E. A. Clark. 1996. Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J. Immunol. 157:4363.
25. Björck, P., L. Florès-Romo, and Y. J. Liu. 1997. Human interdigitating dendritic cells directly stimulate CD40-activated naive B cells. Eur. J. Immunol. 27:1266.
26. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360:258.
27. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. J. Exp. Med. 184:695.
28. Garrone, P., E. M. Neidhardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265.
29. Peltz, G. A., M. L. Trounstine, and K. W. Moore. 1988. Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation. J. Immunol. 141:1891.
30. + bone marrow precursors cultured with c-kit-ligand, GM-CSF, and TNF-α. J. Immunol. 154:5851.
31. Defrance, T., B. Vanbervliet, F. Brière, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor β cooperate to induce antiCD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
32. Liu, Y. J., C. Barthélémy, O. de Bouteiller, C. Arpin, I. Durand, and J. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7.1 and B7.2. Immunity 2:238.
33. Defrance, T., B. Vanbervliet, J. Pène, and J. Banchereau. 1988. Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J. Immunol. 141:2000.
34. Nonoyama, S., D. Hollenbaugh, A. Aruffo, J. A. Ledbetter, and H. D. Ochs. 1993. B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells. J. Exp. Med. 178:1097.
35. Blanchard, D., C. Gaillard, P. Hermann, and J. Banchereau. 1994. Role of CD40 antigen and interleukin-2 in T cell dependent human B lymphocyte growth. Eur. J. Immunol. 24:330.
36. de Saint-Vis, B., I. Fugier-Vivier, C. Massacrier, B. Vanbervliet, S. Aït-Yahia, J. Banchereau, Y. J. Liu, S. Lebecque, and C. Caux. 1998. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. 160:1666.
37. Burdin, N., K. van Kooten, L. Galibert, J. S. Abrams, J. Wijdenes, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
38. Fluckiger, A. C., P. Garrone, I. Durand, J. P. Galizzi, and J. Banchereau. 1993. Interleukin 10 (IL-101) up-regulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178:1473.
39. Akira, S., T. Taga, and T. Kishimoto. 1993. Interleukin-6 in biology and medicine. Adv. Immunology. 54:1.
40. Stashenko, P., L. M. Nadler, R. Hardy, and S. F. Schlossman. 1981. Expression of cell surface markers after human B lymphocyte activation. Proc. Natl. Acad. Sci. USA 78:3848.
41. Arpin, C., J. Déchanet, C. van Kooten, P. Merville, G. Grouard, F. Brière, J. Banchereau, and Y. J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
42. Burdin, N., L. Galibert, P. Garrone, I. Durand, J. Banchereau, and F. Rousset. 1996. Inability to produce interleukin-6 is a functional feature of human germinal center B lymphocytes. J. Immunol. 156:4107.
43. Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167:332.
44. Beagley, K. W., J. H. Eldridge, F. Lee, H. Kiyono, M. P. Everson, W. J. Koopman, T. Hirano, T. Kishimoto, and J. R. McGhee. 1989. Interleukins and IgA synthesis: human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J. Exp. Med. 169:2133.
45. Tamura, T., N. Udagawa, N. Takahashi, C. Miyaura, S. Tanaka, Y. Yamada, Y. Koishihara, Y. Ohsugi, K. Kumaki, and T. Taga. 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc. Natl. Acad. Sci. USA 90:11924.
46. Peters, M., S. Jacobs, M. Ehlers, P. Vollmer, J. Mullberg, E. Wolf, G. Brem, K. H. Meyer zum Buschenfelde, and S. Rose John. 1996. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J. Exp. Med. 183:1399.
47. Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga, and T. Kishimoto. 1990. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149.
48. Saito, M., K. Yoshida, M. Hibi, T. Taga, and T. Kishimoto. 1992. Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 148:4066.
49. Rettig, M. B., H. J. Ma, R. A. Vescio, M. Fold, G. Schiller, D. Belson, A. Savage, C. Nishikubo, C. Wu, J. Fraser, J. W. Said, and J. R. Berenson. 1997. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276:1851.
50. Lamont, A. G., and L. Adorini, 1996. IL-12: a key cytokine in immune regulation. Immunol. Today 17:214.
51. Jelinek, D. F., and J. K. Braaten. 1995. Role of IL-12 in human B lymphocyte proliferation and differentiation. J. Immunol. 154:1606.
52. Li, L., D. Young, S. F. Wolf, and Y. S. Choi. 1996. Interleukin-12 stimulates B cell growth by inducing IFN-γ. Cell. Immunol. 168:133.
53. Chan, S. H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12): role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148:92.
54. Gately, M. K., B. B. Desai, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, F. J. Podlaski, P. C. Familletti, F. Sinigaglia, R. Chizonnite, and U. Gubler. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
55. Metzger, D. W., L. A. Vogel, V. H. van Cleave, T. L. Lester, and J. M. Buchanan. 1996. The effects of IL-12 on B-cell subset function. Res. Immunol. 7/8:499.
56. Wu, C. Y., R. R. Warrier, D. M. Carvajal, A. O. Chua, L. J. Minetti, R. Chizzonite, P. K. Mongini, A. S. Stern, U. Gubler, D. H. Presky, and M. K. Gately. 1996. Biological function and distribution of human interleukin-12 receptor β chain. Eur. J. Immunol. 26:345.
57. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
58. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
59. Afonso, L. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
60. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b, and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25:823.
61. Buchanan, J. M., L. A. Vogel, V. H. van Cleave, and D. W. Metzger. 1995. Interleukin 12 alters the isotype-restricted antibody response of mice to hen egg-white lysozyme. Int. Immunol. 7:1519.
62. Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068.
63. Chehimi, J. 1995. Interleukin-12 in the pathogenesis and therapy of HIV disease. Res. Immunol. 146:605.
64. Bouharoun-Tayoun, H., P. Attanah, A. Sabchareon, T. Chongsuphajaisiddhi, and P. Druilhe. 1990. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J. Exp. Med. 172:1633.
65. + T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi. Eur. J. Immunol. 21:1433.