Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection

Infection and Immunity

Volumn 69, Issue 4, 2001, Pages 2456-2461

  Demangel, C ^a   Palendira, U ^a   Feng, C G ^a   Heath, A W ^a   Bean, A G D ^a   Britton, W J ^a  

^a CENTENARY INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CD40 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; BCG VACCINATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HUMORAL IMMUNITY; LUNG TUBERCULOSIS; MEDIASTINUM LYMPH NODE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CD40 LIGAND; CELLS, CULTURED; DENDRITIC CELLS; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; RNA, MESSENGER;

EID: 0035077847     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.4.2456-2461.2001     Document Type: Article

References (35)

1. Human dendritic cell (DC)-based anti-infective therapy: Engineering DCs to secrete functional IFN-γ and IL-12
2. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
3. The role of IL-18 in innate immunity
4. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
5. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
6. Origin, maturation and antigen presenting function of dendritic cells
7. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
8. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature
9. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis
10. Disseminated tuberculosis in IFN-γ gene-disrupted mice
11. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
12. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection
13. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells
14. Effect of interleukin-10 on dendritic cell maturation and function
15. Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance Monitoring Project
16. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 monoclonal antibody
17. An essential role for IFN-γ in resistance to Mycobacterium tuberculosis infection
18. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
19. CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis
20. The CD40-CD154 system in anti-infective host defense
21. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
22. Monoclonal antibodies to murine CD40 define two distinct functional epitopes
23. Activation of human dendritic cells following infection with Mycobacterium tuberculosis
24. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
25. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
26. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
27. Cytokine chemokine cascades in immunity to tuberculosis
28. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
29. The role of dendritic cells in the induction and regulation of immunity to microbial infection
30. Paralysis of dendritic cell IL-12 production by microbial products prevents infection induced immunopathology
31. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
32. Mycobacterium tuberculosis-activated dendritic cells induce protective immunity in mice
33. Bacillus Calmette-Guerin mycobacteria stimulate human blood dendritic cells
34. Immunoregulation by interleukin-12
35. Functions of CD40 on B cells, dendritic cells and other cells