The immunological synapse: A molecular machine controlling T cell activation

Science

Volumn 285, Issue 5425, 1999, Pages 221-227

  Grakoui, Arash ^a   Bromley, Shannon K ^a   Sumen, Cenk ^b   Davis, Mark M ^b   Shaw, Andrey S ^a   Allen, Paul M ^a   Dustin, Michael L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; HUMAN; IMMUNOMODULATION; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD4; CELL MOVEMENT; CHO CELLS; CRICETINAE; CYTOCHROME C GROUP; FLUORESCENCE; HISTOCOMPATIBILITY ANTIGENS; INTERCELLULAR ADHESION MOLECULE-1; LIGANDS; LIPID BILAYERS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROSCOPY, INTERFERENCE; MODELS, IMMUNOLOGICAL; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS;

EID: 0033538574     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5425.221     Document Type: Article

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59. We thank R. Houdei for technical assistance and N. Desai for advice on imaging and data analysis; D. Donermeyer for generation of the 3.12 TCR transgenic mouse lacking CD4; E. Unanue for inspiring our efforts; E. Elson for help with FPR and the loan of the argon ion lasen J. Heuser and H. Hiyakawa for single-particle imaging; A. Chan, C. Kersh, M. Thomas, E. Unanue, and H. Virgin for critical reading of the manuscript; and J. Smith for final preparation of the manuscript. Supported by grants from the Whitaker Foundation (M.L.D.), the Arthritis Foundation (M.L.D.), the Howard Hughes Medical Institute (M.M.D.), and the NIH (M.L.D., M.M.D., P.M.A, and A.S.S.).