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Volumn 12, Issue 1, 2000, Pages 114-121

The control of T cell responses by dendritic cell subsets

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

EID: 0033966740     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00059-X     Document Type: Review
Times cited : (212)

References (77)
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    • Reciprocal control of T helper cell and dendritic cell differentiation
    • + T helper cell responses. MDCs (DC1) and plasmacytoid-derived DCs (DC2) were co-cultured with T cells and the ensuing cytokine secretion measured. DC1 cells induced T cells of a Th1 phenotype, and DC2, a Th2 phenotype. Unlike DC2, DC1 secreted high levels of IL-12, but IL-4 production by DC2 could not be detected at the protein or mRNA level. A regulatory mechanism for the differentiation of Th cells based on DC subsets is proposed
    • + T helper cell responses. MDCs (DC1) and plasmacytoid-derived DCs (DC2) were co-cultured with T cells and the ensuing cytokine secretion measured. DC1 cells induced T cells of a Th1 phenotype, and DC2, a Th2 phenotype. Unlike DC2, DC1 secreted high levels of IL-12, but IL-4 production by DC2 could not be detected at the protein or mRNA level. A regulatory mechanism for the differentiation of Th cells based on DC subsets is proposed.
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