The role of chemokines in the regulation of dendritic cell trafficking

Journal of Leukocyte Biology

Volumn 66, Issue 1, 1999, Pages 1-9

  Sozzani, Silvano ^a   Allavena, Paola ^b   Vecchi, Annunciata ^b   Mantovani, Alberto ^b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Ist di Ric Farmacologiche 'M ^*

Author keywords

Adhesion; Cell migration; Immune response; Lymph nodes; Tumor

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR;

ANIMAL CELL; CARCINOGENESIS; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL TRANSPORT; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOBIOLOGY; LYMPH NODE; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0033060632     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.1.1     Document Type: Review

References (106)

1. Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
2. Hart, D. N. J. (1997) Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90, 3245-3286.
3. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
4. Austyn, J. M. (1996) New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183, 1287-1292.
5. Macpherson, G. G., Jenkins, C. D., Stein, M. J., Edwards, C. (1995) Endotoxin-mediated dendritic cell release from the intestine - Characterization of released dendritic cells and TNF dependence. J. Immunol. 154, 1317-1322.
6. Roake, J. A., Rao, A. S., Morris, P. J., Larsen, C. P., Hankins, D. F., Austyn, J. M. (1995) Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181, 2237-2247.
7. De Smedt, T., Pajak, B., Muraille, E., Lespagnard, L., Heinen, E., Debaetselier, P., Urbain, J., Leo, O., Moser, M. (1996) Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184, 1413-1424.
8. Springer, T. A. (1994) Traffic signal for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
9. Sallusto, F., Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor-alpha. J. Exp. Med. 179, 1109-1118.
10. Sozzani, S., Sallusto, F., Luini, W., Zhou, D., Piemonti, L, Allavena, P., Van Damme, J., Valitutti, S., Lanzavecchia, A., Mantovani, A. (1995) Migration of dendritic cells in response to formyl peptides, C5a and a distinct set of chemokines. J. Immunol. 155, 3292-3295.
11. Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L., D'Amico, G., Power, C. A., Wells, T. N., Gobhi, M., Allavena, P., Mantovani, A. (1997) Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. Immunol. 159, 1993-2000.
12. Sozzani, S., Allavena, P., D'Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., Mantovani, A. (1998) Cutting edge: Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties. J. Immunol. 161, 1083-1086.
13. D'Amico, G., Bianchi, G., Bernasconi, S., Bersani, L., Piemonti, L., Sozzani, S., Mantovani, A., Allavena, P. (1998) Adhesion, transendothelial migration, and reverse transmigration of in vitro cultured dendritic cells. Blood 92, 207-214.
14. McCarthy, D. A., Macey, M. G., Bedford, P. A., Knight, S. C., Dumonde, D. C. (1997) Adhesion molecules are upregulated on dendritic cells isolated from human blood. Immunology 92, 244-251.
15. Le Varlet, B., Staquet, M. J., Dezutter-Dambuyant, C., Delorme, P. S. (1992) In vitro adhesion of human epidermal Langerhans cells to laminin and fibronectin occurs through beta 1 integrin receptors. J. Leukoc. Biol. 51, 415-420.
16. Udey, M. C. (1997) Cadherins and Langerhans cell immunobiology. Clin. Exp. Immunol. 107, 6-8.
17. Günthert, U., Hofmann, M., Rudy, W., Reber, S., Zöller, M., Matzku, S., Wenzel, A., Ponta, H., Herrlich, P. (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65, 13-24.
18. Weiss, J. M., Sleeman, J., Renkl, A. C., Dittmar, H., Termeer, C. C., Howells, N., Hofmann, M., Kohler, G., Schopf, E., Ponta, H., Herrlich, P. S. (1997) An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function. J. Cell Biol. 137, 1137-1147.
19. Fanales-Belasio, E., Zambruno, G., Cavani, A.. Girolomoni, G. (1997) Antibodies against sialophorin (CD43) enhance the capacity of dendritic cells to cluster and activate T lymphocytes. J. Immunol. 159, 2203-2211.
20. + peripheral blood mononuclear cells migrate across endothelium and give rise to immunostimulatory dendritic cells. J. Immunol. 160, 2675-2683.
21. Vecchi, A., Massimiliano, L., Ramponi, S., Luini, W., Bernasconi, S., Bonecchi, R., Allavena, P., Parmentier, M., Mantovani, A., Sozzani, S. (1999) Differential responsiveness to constitutive versus inflammatory chemokines of immature and mature mouse dendritic cells. J. Leukoc. Biol., in press.
22. Muller, W. A., Weigl, S. A. (1992) Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay. J. Exp. Med. 176, 819-828.
23. Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M., Muller, W. A. (1998) Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282, 480-483.
24. Randolph, G. J., Beaulieu, S., Pope, M., Sugawara, I., Hoffman, L., Steinman, R. M., Muller, W. A. (1998) A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels. Proc. Natl. Acad. Sci. USA 95, 6924-6929.
25. Oppenheim, J. J., Zachariae, C. O., Mukaida, N., Matsushima, K. (1991) Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol. 9, 617-648.
26. Baggiolini, M., Dewald, B., Moser, B. (1997) Human chemokines: An update. Annu. Rev. Immunol. 15, 675-705.
27. Hedrick, J. A., Zlotnik, A. (1996) Chemokines and lymphocyte biology. Curr. Opin. Immunol. 8, 343-347.
28. Rollins, B. J. (1997) Chemokines. Blood 90, 909-928.
29. Mantovani, A., Allavena, P.. Vecchi, A., Sozzani, S. (1998) Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of Th1 versus Th2 responses. Int. J. Clin. Lab. Res. 28, 77-82.
30. Luster, A. D. (1998) Chemokines - chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338, 436-445.
31. Mantovani, A., Bussolino, F., Introna, M. (1997) Cytokine regulation of endothelial cell function: from molecular level to the bed side. Immunol. Today 18, 231-239.
32. Bonecchi, R., Sozzani, S., Stine, J., Luini, W., D'Amico, G., Allavena, P., Chantry, D., Mantovani, A. (1998) Divergent effects of IL-4 and interferon gamma on macrophage-derived chemokine (MDC) production: an amplification circuit of polarazied T helper 2 responses. Blood 92, 2668-2671.
33. Polentarutti, N., Introna, M., Sozzani, S., Mancinelli, R., Mantovani, G., Mantovani, A. (1997) Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells. Eur. Cytokine Netw. 8, 271-274.
34. Yoshida, T., Imai, T., Kakizaki, M., Nishimura, M., Takagi, S., Yoshie, O. (1998) Identification of single C motif-1 lymphotaclin receptor XCR1. J. Biol. Chem. 273, 16551-16554.
35. Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., Yoshie, O. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91, 521-530.
36. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., Sinigaglia, F. (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1) and Th2. J. Exp. Med. 187, 129-134.
37. Sallusto, F., Mackay, C. R., Lanzavecchia, A. (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277, 2005-2007.
38. Loetscher, P., Uguccioni, M., Bordoli, L., Baggiolini, M., Moser, B., Chizzolini, C., Dayer, J.-M. (1998) CCR5 is characteristic of Th1 lymphocytes. Nature 391, 344-345.
39. Sica, A., Saccani, A., Borsatti, A., Power, C. A., Wells, T. N. C., Luini, W., Polentarutti, N., Sozzani, S., Mantovani, A. (1997) Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185, 969-974.
40. Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N. C., Biswas, P., Vicenzi, E., Poli, G., Mantovani, A. (1998) Interleukin-10 increases CCR5 expression and HIV infection in human monocytes. J. Exp. Med. 187, 439-444.
41. Polentarutti, N., Allavena, P., Bianchi, G., Giardina, G., Basile, A., Sozzani, S., Mantovani, A., Introna, M. (1997) IL-2 regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4 Kb transcript containing CCR2B and CCR2A sequences. J. Immunol. 158, 2689-2694.
42. Loetscher, P., Seitz, M., Baggiolini, M., Moser, B. (1996) Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J. Exp. Med. 184, 569-577.
43. D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., Sinigaglia, F. (1998) Cutting edge: Selective upregulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 T helper cells, J. Immunol. 161, 5111-5115.
44. Godiska, R., Chantry, D., Raport, C. J., Sozzani, S., Allavena, P., Leviten, D., Mantovani, A., Gray, P. W. (1997) Human macrophage derived chemokine (MDC) a novel chemoattractant for monocytes, monocyte derived dendritic cells, and natural killer cells. J. Exp. Med. 185, 1595-1604.
45. Mohamadzadeh, M., Poltorak, A. N., Bergstresser, P. R., Beutler, B., Takashima, A. (1996) Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. J. Immunol. 156, 3102-3106.
46. Adema, G. J., Hartgers, F., Verstraten, R., deVries, E., Marland, G., Menon, S., Foster, J., Xu, Y. M., Nooyen, P., McClanahan, T., Bacon, K. B., Figdor, C. G. (1997) A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387, 713-717.
47. Vicari, A. P., Figueroa, D. J., Hedrick, J. A., Foster, J. S., Singh, K. P., Menon, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bacon, K. B., Zlotnik, A. (1997) TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7, 291-301.
48. Zhou, L. J., Tedder, T. F. (1995) A distinct pattern of cytokine gene expression by human CD83(+) blood dendritic cells. Blood 86, 3295-3301.
49. Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Vankooten, C., Durand, I., Banchereau, J. (1994) Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180, 1263-1272.
50. Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S., Lanzavecchia, A. (1998) Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28, 2760-2769.
51. Dieu, M. C., Vanbervliet, B., Vicari, A., Bridon, J-M., Oldham, E., Ait-Yahia, S., Briere, F., Zlotnik, A., Lebecque, S., Caux, C. (1998) Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites, J. Exp. Med. 188, 373-386.
52. Ngo, V. N., Tang, H. L., Cyster, J. G. (1998) Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J. Exp. Med. 188, 181-191.
53. Gunn, M. D., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L. T., Nakano, H. (1999) Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460.
54. Sozzani, S., Longoni, D., Bonecchi, R., Luini, W., Bersani, L., D'Amico, G., Borsatti, A., Bussolino, F., Allavena, P., Mantovani, A. (1997) Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor. FEBS Lett. 418, 98-100.
55. Imai, T., Chantry, D., Raport, C. J., Wood, C. L, Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273, 1764-1768.
56. Yoshida, R., Imai, T., Hieshima, K., Kusuda, J., Baba, M., Kitaura, M., Nishimura, M., Kakizaki, M., Nomiyama, H., Yoshie, O. (1997) Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272, 13803-13809.
57. Ayehnie, S., Garcia-Zepeda, E. A., Hoxie, J. A., Horuk, R., Kupper, T. S., Luster, A. D., Ruprecht, R. M. (1997) Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood 90, 1379-1386.
58. Power, C. A., Church, D. J., Meyer, A., Alouani, S., Proudfoot, A. E. I., Clark-Lewis, I., Sozzani, S., Mantovani, A., Wells, T. N. C. (1997) Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3 alpha from lung dendritic cells. J. Exp. Med. 186, 825-335.
59. Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu, M. C., de Saint-Vis, B., Franz-Bacon, K., Rossi, D., Caux, C., McClanahan, T., Gordon, S., Zlotnik, A., Schall, T. J. (1997) CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3 alpha and is highly expressed in human dendritic cells. J. Exp. Med. 186, 837-844.
60. Baba, M., Imai, T., Nishimura, M., Kakizaki, M., Takagi, S., Hieshima, K., Nomiyama, H., Yoshie, O. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. Biol. Chem. 272, 14893-14898.
61. Graziosi, C., Pantaleo, G. (1998) The multi-faceted personality of HIV. Nature Med. 12, 1318-1320.
62. Cameron, P. U., Freudenthal, P. S., Barker, J. M., Gezelter, S., Inaba, K., Steinman, R. M. (1992) Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257, 383-387.
63. Granelli-Piperno, A., Moser, B., Pope, M., Chen, D. L., Wei, Y., Isdell, F., O'Doherty, U., Paxton, W., Koup, R., Mojsov, S., Bhardwaj, N., Clarklewis, I., Baggiolini, M., Steinman, R. M. (1996) Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J. Exp. Med. 184, 2433-2438.
64. Granelli-Pipenio, A., Delgado, E., Finkel, V., Paxton, W., Steinman, R. M. (1998) Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M-and T-Tropic virus to T cells. J. Virol. 72, 2733-2737.
65. Reece, J. C., Handley, A. J., Anstee, E. J., Morrison, W. A., Crowe, S. M. (1998) HIV-1 selection by epidermal dendritic cells during transmission across human skin. J. Exp. Med. 187, 1623-1631.
66. Zaitseva, M., Blauvelt, A., Lee, S., Lapham, C. K., Klaus-Kovtun, V., Motowski, H., Manischewitz, J., Golding, H. (1997) Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implication for HIV primary infection. Nature Med. 3, 1369-1375.
67. Rubbert, A., Combadiere, C., Ostrowski, M., Arthos, J., Dybul, M., Machado, E., Cohn, M. A., Hoxie, J., Murphy, P. M., Fauci, A. S., Weissman, D. (1998) Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J. Immunol. 160, 3933-3941.
68. Xu, L. L., Warren, M. K., Rose, W. L., Gong, W. H., Wang, J. M. (1996) Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. J. Leukoc. Biol. 60, 365-371.
69. Nakamura, K., Williams, I. R., Kupper, T. S. (1995) Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhan's cells to skin. J. Invest. Dermatol. 105, 635-643.
70. Morelli, A., Larregina, A., Chuluyan, E., Kolkowski, E., Fainboim, L. (1996) Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells. Immunol. 89, 126-134.
71. McWilliam, A. S., Napoli, S., Marsh, A. M., Pemper, F. L., Nelson, D. J., Pimm, C. L., Stumbles, P. A., Wells, T. N. C., Holt, P. G. (1996) Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J. Exp. Med. 184, 2429-2432.
72. Cella, M., Sallusto, F., Lanzavecchia, A. (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9, 10-16.
73. Penton-Rol, G., Polenlarutti, N., Luini, W., Borsatti, A., Mancinelli, R., Sica, A., Sozzani, S., Mantovani, A. (1998) Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ. J. Immunol. 160, 3869-3873.
74. Xu, L., Rahimpour, R., Ran, L., Kong, C., Biragyn, A., Andrews, J., Devries, M., Wang, J. M., Kelvin, D. J. (1997) Regulation of CCR2 chemokine receptor mRNA stability. J. Leukoc. Biol. 62, 653-660.
75. Tangirala, R. K., Murao, K., Quehenbetger, O. (1997) Regulation of expression of the human monocyte chemotactic protein-1 receptor (hCCR2) by cytokines. J. Biol. Chem. 272, 8050-8056.
76. Yanagihara, S., Komura, E., Nagafune, J., Watarai, H., Yamaguchi, Y. (1998) EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J. Immunol. 161, 3096-3102.
77. Lin, C. L., Suri, R. M., Rahdon, R. A., Austyn, J. M., Roake, J. A. (1998) Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation. Eur. J. Immunol. 28, 4114-4122.
78. Foti, M., Granucci, D., Aggujaro, D., Luini, W., Minardi, S., Mantovani, A., Sozzani, S., Ricciardi-Castagnoli, P. (1999) Upon dendritic cell activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of dendritic cells at the inflammatory site. Int. Immunol., in press.
79. Lloyd, A. R., Biragyn, A., Johnston, J. A., Taub, D. D., Xu, L. L., Michiel, D., Sprenger, H., Oppenheim, J. J., Kelvin, D. J. (1995) Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J. Biol. Chem. 270, 28188-28192.
80. Willimann, K., Legler, D. F., Loetscher, M., Stuber Roos, R., Delgado, M. B., Clark-Lewis, I., Baggiolini, M., Moser, B. (1998) The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur. J. Immunol. 28, 2025-2034.
81. Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., Williams, L. T. (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemolaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA 95, 258-263.
82. Mantovani, A. (1994) Tumor-associated macrophages in neoplaslic progression: A paradigm for the in vivo function of chemokines. Lab. Invest. 71, 5-16.
83. Zeid, N. A., Muller, H. K. (1993) S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival. Pathology 25, 338-343.
84. Furukawa, T., Watanabe, S.. Kodama, T., Sato, Y., Shimosato, Y. (1985) T-zone histiocytes in adenocarcinoma of the lung in relation to postoperative prognosis. Cancer 56, 2651-2656.
85. Ambe, K., Mori, M., Enjoji, M. (1989) S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis. Cancer 63, 496-503.
86. Schroder, S., Schwarz, W., Rehpenning, W., Loning, T., Bocker, W. (1988) Dendritic/Langerhans cells and prognosis in patients with papillary thyroid carcinomas. Immunocytochemical study of 106 thyroid neoplasms correlated to follow-up data. Am. J. Clin. Pathol. 89, 295-300.
87. Tsujitani, S., Furukawa, T., Tamada, R., Okamura, T., Yasumoto, K. (1987) Langerhans cells and prognosis in patients with gastric carcinoma. Cancer 59, 501-505.
88. Nomori, H., Watanabe, S., Nakajima, T., Kameya, T. (1986) Histiocytes in nasopharyngeal carcinoma in relation to prognosis. Cancer 57, 100-105.
89. Goldman, S. A., Baker, E., Weyant, R. J., Clarke, M. R., Myers, J. N., Lotze, M. T. (1998) Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma. Arch. Otlar.-Head Neck Surg. 124, 641-646.
90. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., Mulligan, R. C. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 90, 3539-3543.
91. Levitsky, H. I., Montgomery, J., Ahmadzadeh, M., Guarnieri, F., Longo, D. L., Kwak, L. W. (1996) Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J. Immunol. 156, 3858-3865.
92. Armstrong, C. A., Botella, R., Galloway, T. H., Murray, N., Kramp, J. M., , Song, I. S., Ansel, J. C. (1996) Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells. Cancer Res. 56, 2191-2198.
93. Qin, Z., Noffz, G., Mohaupt, M., Blankenstein, T. (1997) Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells. J. Immunol. 159, 770-776.
94. Longoni, D., Piemonti, L., Bernasconi, S., Mantovani, A., Allavena, P. (1998) Interleukin-10 increases mannose receptor expression and endocytic activity in monocyte-derived dendritic cells. Int. J. Clin. Lab. Res. 28, 162-169.
95. Thomssen, H., Kahan, M., Londei, M. (1995) Differential effects of interleukin-10 on the expression of HLA class II and CD1 molecules induced by granulocyte/macrophage colony-stimulating factor/interleukin-4. Eur. J. Immunol. 25, 2465-2470.
96. De Smedt, T., Van Mchelen, M. E., De Becker, G., Urbain, J., Leo, O., Moser, M. (1997) Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. 27, 1229-1235.
97. Buelens, C., Verhasselt, V, De Groote, D., Thielemans, K., Goldman, M., Willems, F. (1997) Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with Interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur. J. Immunol. 27, 756-762.
98. Allavena, P., Piemonti, L., Longoni, D., Bernasconi, S., Stoppacciaro, A., Ruco, L., Mantovani, A. (1998) Interleukin-10 prevents the differentation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur. J. Immunol. 28, 359-369.
99. Stoppacciaro, A., Paglia. P., Lombardi, L., Parmiani, G., Baroni, C., Colombo, M. P. (1997) Genetic modification of a carcinoma with the 1L-4 gene increases the influx of dendritic cells relative to other cytokines. Eur. J. Immunol. 27, 2375-2382.
100. Nanni, P., Rossi, I., De Giovanni, C., Landuzzi. L., Nicoletti, G., Stoppacciaro, A., Parenza, M., Colombo, M. P., Lollini, P. L. (1998) Interleukin 12 gene therapy of MHC-negative murine melanoma metastases. Cancer Res. 58, 1225-1230.
101. Fioretti, F., Fradelizi, D., Stoppacciaro, A., Ruco, L., Minty, A., Sozzani, S., Vecchi, A., Mantovani, A. (1998) Reduced tumorigenicity and augmented leukocyte infiltration after MCP-3 gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. J. Immunol. 161, 342-346.
102. Nagira, M., Imai, T., Hieshima, K., Kusuda, J., Ridanpaa, M., Takagi, S., Nishimura, M., Kakizaki, M., Nomiyama, H., Yoshie, O. (1997) Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. J. Biol. Chem. 272, 19518-19524.
103. Ngo, V. N., Komer, H., Gunn, M. D., Scmidt, K. N., Riminton, D. S., Cooper, M. D., Browning, J. L. Sedgwick, J. D., Cyster, J. G. (1999) Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412.
104. Wang, B., Fujisawa, H., Zhuang, L., Kondo, S., Shivji, G. M., Kim, C. S., Mak, T. W., Sauder, D. N. (1997) Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75. J. Exp. Med. 159, 6148-6155.
105. Saeki, H., Moore, A. M., Brown, M. J., Hwang, S. T. (1999) Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162, 2472-2475.
106. Cyster, J. G. (1999) Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J. Exp. Med. 189, 447-450.