Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive t cells and induction of peripheral allograft tolerance

Nature Medicine

Volumn 5, Issue 11, 1999, Pages 1298-1302

  Li, Yongsheng ^a   Li, Xian Chang ^a   Zheng, Xin Xiao ^a   Wells, Andrew D ^b   Turka, Laurence A ^b   Strom, Terry B ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CYCLOSPORIN A; LIGAND; RAPAMYCIN;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; HEART TRANSPLANTATION; HISTOCOMPATIBILITY TEST; IMMUNOTHERAPY; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN ALLOGRAFT; T LYMPHOCYTE ACTIVATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL DIVISION; GRAFT SURVIVAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0344613988     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/15256     Document Type: Article

References (22)

1. Warrens, A.N., Lombardi, G. & Lechler, R.I. Presentation and recognition of major and minor histocompatibility antigens. Transpl. Immunol. 2, 103-107 (1994).
2. Dai, Z., Konieczny, B.T., Baddoura, F.K. & Lakkis, F.G. Impaired alloantigen mediated T-cell apoptosis and failure to induce long term allograft survival in IL-2 deficient mice. J. Immunol. 161, 1659-1663 (1998).
3. Li, X.C., Zheng, X.X., Zand, M.S., Li, Y. & Strom, T.B. IL-2 dependent rapamycin resistent signals are required for tolerance induction and T-cell apoptosis. Transplantation 65, 5169-665 (1998).
4. Abraham, R.T. & Wiederrecht, G.J. Immunopharmacology of rapamycin. Annu. Rev. Immunol. 14, 483-510 (1996).
5. Bierer, B.E. et al. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl. Acad. Sci. USA 87, 9231-9235 (1990).
6. Ikuta, K., Uchida, N., Friedman, J. & Weissman, I.L. Lymphocyte development from stem cells. Annu. Rev. Immunol. 10, 759-783 (1992).
7. Lenschow, D.J. et al. Long term survival of xenogeneic pancreatic islet grafts induced by CTLA-4lg. Science 257, 789-792 (1992).
8. Larsen, C.P. et al. Long term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381, 434-438 (1996).
9. Kirk, A.D. et al. CTLA-4lg and anti-CD40L prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. USA 94, 8789-8794 (1997).
10. Kirk, A.D. et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Med. 5, 686-693 (1999).
11. Sykes, M. Chimerism and central tolerance. Curr. Opin. Immunol. 8, 694-703 (1996).
12. Schreiber, S.L. & Crabtree, G.R. The mechanism of action of cyclosporine A and FK 506. Immunol. Today 13, 136-142 (1992).
13. Shi, Y.F., Sahai, B.M. & Green, D.R. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Science 339, 625-626 (1989).
14. Yazdanbakhsh, K., Choi, J. W., Li, Y., Lau, L.F. & Choi, Y. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcriptional factor Nur77. Proc. Natl. Acad. Sci. USA 92, 437-441 (1995).
15. Adachi, M. et al. Interleukin-2 upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta chain. Blood 88, 4118-4123 (1996).
16. Wells, A. D., Gudmundsdottir, H. & Turka, L. A. Following the fate of individual T cells throughout activation and clonal expansion. J. Clin. Invest. 100, 3173-3183 (1997).
17. Boise, L. H. et al. CD28 co-stimulation can promote T-cell survival by enhancing the expression of Bcl-XL. Immunity 3, 87-98 (1995).
18. Cobbold, S. & Waldmann, H. Infectious tolerance. Curr. Opin. Immunol. 10, 518-524 (1998).
19. Li, X. C., Zand, M. S., Li, Y., Zheng, X. X. & Strom, T. B. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J. Immunol. 161, 2241-2247 (1998).
20. Tivol, E.A. et al. CTLA-4lg prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4 deficient mice. J. Immunol. 158, 5091-5094 (1997).
21. Larsen, C.P., Morris, P.J. & Austyn, J.M. Migration of dendritic leukocytes from cardiac allografts into host spleens. J. Exp. Med. 171, 307-314 (1990).
22. Song, H. K. et al. Alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 co-stimulation. J. Immunol. 162, 2467-2471 (1999).