CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6889-6895

  Askew, D ^a   Chu, R S ^a   Krieg, A M ^a   Harding, C V ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BREFELDIN A; CD40 ANTIGEN; CD86 ANTIGEN; COMPLEMENTARY DNA; CYTOKINE; DNA; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0034671944     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6889     Document Type: Article

References (46)

1. Dendritic cells and the control of immunity
2. Origin, maturation and antigen presenting function of dendritic cells
3. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
4. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain
5. Class II major histocompatibility complex molecules of murine dendritic cells synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture
6. Presentation of exogenous protein antigens by dendritic cells to T cell clones intact protein is best presented by immature, epidermal Langerhans cells
7. Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells
8. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo
9. Maturation stages of mouse dendritic cells m growth factor-dependent long-term cultures
10. Developmental regulation of MHC class II transport m mouse dendritic cells
11. Phagocytosis of antigens by Langerhans cells in vitro
12. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules m mouse dendritic cells
13. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment downregulation by cytokines and bacterial products
14. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides a role for dendritic cells in the augmentation of Th1 responses by immuno-stimulatory DNA
15. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
16. Activation of human dendritic cells following infection with Mycobacterium tuberculosis
17. CpG DNA a potent signal for growth, activation, and maturation of human dendritic cells
18. Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells
19. CpG motifs in bacterial DNA trigger direct B cell activation
20. Bacterial CpG DNA activates immune cells to signal infectious danger
21. CpG motifs as immune adjuvants
22. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
23. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
24. CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance anti-polysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies
25. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
26. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen a new class of vaccine adjuvants
27. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
28. CpG DNA can reduce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen m young mice
29. CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing
30. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distract processing mechanisms
31. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
32. Enrichment and characterization of dendritic cells from human bronchoalveolar lavages
33. Techniques for studying phagocytic processing of bacteria for class I or II MHC-restricted antigen recognition by T lymphocytes
34. Inhibition of class II MHC antigen processing and presentation by Escherichia coli heatlabile enterotoxin requires an enzymatically active A subunit
35. 3H]thymidine incorporation assay
36. High-speed prothrombin G→A 20210 and methylenetetrahydrofolate reductase C→T 677 mutation detection using real-time fluorescence PCR and melting curves
37. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR
38. Rapid detection of CYP2C9*3 alleles by real-time fluorescence PCR based on SYBR Green
39. Interferon-γ differentially regulates antigen processing functions m distract endocytic compartments of macrophages with constitutive expression of class II MHC molecules
40. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells
41. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
42. Regulation of dendritic ceil numbers and maturation by lipopolysaccharide in vivo
43. The endocytic activity of dendritic cells
44. Maturation, activation, and protection of dendritic cells induced by doublestranded RNA
45. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
46. Coordinated events during bacteria-induced DC maturation Immunol Today