A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ

Journal of Immunology

Volumn 159, Issue 5, 1997, Pages 2125-2131

  Ahn, Hyun Jong ^a   Maruo, Seiji ^a   Tomura, Michio ^a   Mu, Jie ^a   Hamaoka, Toshiyuki ^a   Nakanishi, Kenji ^b   Clark, Steven ^c   Kurimoto, Masashi ^d   Okamura, Haruki ^b   Fujiwara, Hiromi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c PFIZER INC   (United States)

^d HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; T LYMPHOCYTE;

ANIMALS; CELLS, CULTURED; CYTOKINES; DRUG SYNERGISM; FEMALE; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 0031230444     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Trinchieri, G., and B. Perussia. 1985. Immune Interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today 6:131.
2. Dinarello, C. A. 1989. Interleukin-1 and its biologically related cytokines. Adv. Immunol. 44:153.
3. Hirano, T., S. Akira, T. Taga, and T. Kishimoto. 1990. Biological and clinical aspects of interleukin 6. Immunol. Today 11:443.
4. Tracey, K. J., and A. Cerami. 1993. Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol. 9:317.
5. Chen, L. K., B. Tourvieille, G. F. Burns, F. H. Bach, D. Mathieu-Mahul, M. Sasportes, and A. Bensussan. 1986. Interferon: a cytotoxic T lymphocyte differentiation signal. Eur. J. Immunol. 16:767.
6. Maraskovsky, E., W. F. Chen, and K. Shortman. 1989. IL-2 and IFN-γ are two necessary lymphokines in the development of cytolytic T cells. J. Immunol. 143:1210.
7. Nathan, C. F., and J. Hibbs, Jr. 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:65.
8. Collart, M. A., D. Belin, J. D. Vassalli, S. de-Kossodo, and P. Vassalli. 1986. Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin I, and urokinase genes, which are controlled by short-lived repressers. J. Exp. Med. 164:2113.
9. Ruggiero, V., J. Tavernier, W. Fiers, and C. Baglioni. 1986. Induction of the synthesis of tumor necrosis factor receptors by interferon-γ. J. Immunol. 136:2445.
10. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051.
11. Lindstein, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.