Induction of interferon-γ production in Th1 CD4+ T cells: Evidence for two distinct pathways for promoter activation

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 548-555

  Yang, Jianfei ^a   Murphy, Theresa L ^a   Ouyang, Wenjun ^a   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokine; IFN ; IL 12; IL 18; Th1

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYCLOSPORIN A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 18; MESSENGER RNA; STAT4 PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HELPER CELL; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD4; DRUG SYNERGISM; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MICE; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 0033033469     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<548::AID-IMMU548>3.0.CO;2-Z     Document Type: Article

References (29)

1. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of T helper lymphocytes. Nature 1996. 383: 787-793.
2. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M.-P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
3. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M., Development of Th1 CD' T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
4. Jacobson, N. G., Szabo, S. J., Weber-Nordt, R. M., Zhong, Z., Schreiber, R. D., Darnell, J. E. Jr. and Murphy, K. M., Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (STAT)3 and Stat4. J. Exp. Med. 1995. 181: 1755-1762.
5. Kaplan, M. H., Sun, Y. L, Hoey, T. and Grusby, M. J., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996. 382: 174-177.
6. Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y., Vignali, D. A., Doherty, P. C., Grosveld, G. C. and Ihle, J. N., Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996. 382: 171-174.
7. Hardy, K. J., Manger, B., Newton, M. and Stobo, J. D., Molecular events involved in regulating human interferon-gamma gene expression during T cell activation. J. Immunol. 1987. 138: 2353-2358.
8. Young, H. A., Komschlies, K. L., Ciccarone, V., Beckwith, M., Rosenberg, M., Jenkins, N. A., Copeland, N. G. and Durum, S. K., Expression of human IFN-gamma genomic DNA in transgenic mice. J. Immunol. 1989. 143: 2389-2394.
9. Ciccarone, V. C., Chrivia, J., Hardy, K. J. and Young, H. A., Identification of enhancer-like elements in human IFN-gamma genomic DNA. J. Immunol. 1990. 144: 725-730.
10. Penix, L, Weaver, W. M., Pang, Y., Young, H. A. and Wilson, C. B., Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J. Exp. Med. 1993. 178: 1483-1496.
11. Aune, T. M., Penix, L. A., Rincon, M. R. and Flavell, R. A., Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells. Mol. Cell. Biol. 1997. 17: 199-208.
12. Young, H. A., Ghosh, P., Ye, J., Lederer, J., Lichtman, A., Gerard, J.R., Penix, L. Wilson, C. B., Melvin, A. J. and McGurn, M. E., Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J. Immunol. 1994. 153: 3603-3610.
13. Ye, J., Cippitelli, M., Dorman, L., Ortaldo, J. R. and Young, H. A., The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol. Cell. Biol. 1996. 16: 4744-4753.
14. Xu, X., Sun, Y. L. and Hoey, T., Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 1996. 273: 794-797.
15. Sica, A., Dorman, L., Viggiano, V., Cippitelli, M., Ghosh, P., Rice, N. and Young, H. A., Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J. Biol. Chem. 1997. 272: 30412-30420.
16. Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y. and Hattori, K., Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995. 378: 88-91.
17. Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y., Okamoto, I., Usui, M., Ikeda, M and Kurimoto, M., IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 1997. 158: 1541-1550.
18. Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K. and Akira, S., Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998. 8: 383-390.
19. Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F. and O'Garra, A., IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity 1997. 7: 571-581.
20. Zhang, T., Kawakami, K., Qureshi, M. H., Okamura, H., Kurimoto, M. and Saito, A., Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma Interferon by natural killer cells. Infect. Immun. 1997. 65: 3594-3599.
21. Barbulescu, K., Becker, C., Schlaak, J. F., Schmitt, E., z.B. Meyer, K. H. and Neurath, M. F., IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4' T lymphocytes. J. Immunol. 1998. 160: 3642-3647.
22. Ahn, H. J., Maruo, S., Tomura, M., Mu, J., Hamaoka, T., Nakanishi, K., Clark, S., Kurimoto, M., Okamura, H. and Fujiwara, H., A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J. Immunol. 1997. 159: 2125-2131.
23. Monte, D., Baert, J. L., Defossez, P. A., de Launoit, Y. and Stehelin, D., Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. Oncogene 1994. 9: 1397-1406.
24. Chan, S. H., Perussia, B., Gupta, J. W., Kobayashi, M., Pospisil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S. C. and Trinchieri, G., Induction of Interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 1991. 173: 869-879.
25. Monte, D., Courte, L., Baert, J. L., Angeli, I., Stehelin, D. and de Launoit, Y, Molecular characterization of the ets-related human transcription factor ER81. Oncogene 1995. 11: 771-779.
26. Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kasiwamura, S.-I., Okamura, H., Akira, S. and Nakanishi, K., IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production. J. Immunol. 1998. 161: 3400-3407.
27. Takadera, T., Leung, S., Gernone, A., Koga, Y., Takihara, Y., Miyamoto, N. G. and Mak, T. W., Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells. Mol. Cell. Biol. 1989. 9: 2173-2180.
28. Gachter, T., Werenskiold, A. K. and Klemenz, R., Transcription of the interleukin-1 receptor-related T1 gene is initiated at different promoters in mast cells and fibroblasts. J. Biol. Chem. 1996. 271: 124-129.
29. Assenmacher, M., Schmitz, J. and Radbruch, A., Flow cytometric determination of cytokines in activated murine T helpfer lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol. 1994. 24: 1097-1101.